HRP20050077B1 - Methods and dosage forms for controlled delivery of paliperidone - Google Patents

Methods and dosage forms for controlled delivery of paliperidone

Info

Publication number
HRP20050077B1
HRP20050077B1 HRP20050077AA HRP20050077A HRP20050077B1 HR P20050077 B1 HRP20050077 B1 HR P20050077B1 HR P20050077A A HRP20050077A A HR P20050077AA HR P20050077 A HRP20050077 A HR P20050077A HR P20050077 B1 HRP20050077 B1 HR P20050077B1
Authority
HR
Croatia
Prior art keywords
paliperidone
concentrations
dosage forms
methods
dosage form
Prior art date
Application number
HRP20050077AA
Other languages
Croatian (hr)
Inventor
Noymi V. Yam
Iran Reyes
Nipun Davar
Atul D. Ayer
Lulie Lee
Original Assignee
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31191280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050077(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corporation filed Critical Alza Corporation
Publication of HRP20050077A2 publication Critical patent/HRP20050077A2/en
Publication of HRP20050077B1 publication Critical patent/HRP20050077B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Predstavljani su oblici doziranja i postupci za omogućavanje pouzdano povećanih rata otpuštanja paliperidona. Postepeno otpuštanje oblika doziranja omogućuje terapeutski učinkovitih prosječnih stabilnih koncentracija paliperidona kad se administrira jednom dnevno. Ovaj režim doziranja jednom dnevno rezultira u samom pojavljivanju vršne koncentracije paliperidona u svakom 24-satnom razdoblju. K tome, vršna koncentracija paliperidona u plazmi javlja se u kasnijem razdoblju nakon administracije doze i ima manju magnitude nego vršna koncentracija paliperidona u plazmi koja nastupa nakon administracije paliperidona u obliku doziranja s trenutnim otpuštanjem.Dosage forms and procedures for reliably increasing paliperidone release rates are presented. Gradual release of the dosage form provides therapeutically effective average stable paliperidone concentrations when administered once daily. This once-daily dosing regimen results in the onset of peak paliperidone concentrations in each 24-hour period. In addition, peak plasma paliperidone concentrations occur at a later period after dose administration and have a lower magnitude than peak plasma paliperidone concentrations occurring after paliperidone administration in the immediate release dosage form.

HRP20050077AA 2002-07-29 2005-01-25 Methods and dosage forms for controlled delivery of paliperidone HRP20050077B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39959002P 2002-07-29 2002-07-29
US40600502P 2002-08-26 2002-08-26
PCT/US2003/023433 WO2004010981A1 (en) 2002-07-29 2003-07-28 Methods and dosage forms for controlled delivery of paliperidone

Publications (2)

Publication Number Publication Date
HRP20050077A2 HRP20050077A2 (en) 2005-12-31
HRP20050077B1 true HRP20050077B1 (en) 2013-11-22

Family

ID=31191280

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050077AA HRP20050077B1 (en) 2002-07-29 2005-01-25 Methods and dosage forms for controlled delivery of paliperidone

Country Status (29)

Country Link
US (1) US20040092534A1 (en)
EP (1) EP1539115B1 (en)
JP (1) JP4500679B2 (en)
KR (1) KR100699516B1 (en)
CN (1) CN1684670A (en)
AR (1) AR040721A1 (en)
AT (1) ATE373472T1 (en)
AU (1) AU2003256844A1 (en)
BR (1) BR0313139A (en)
CA (1) CA2494234C (en)
CO (1) CO5580742A2 (en)
CY (1) CY1107096T1 (en)
DE (1) DE60316454T2 (en)
DK (1) DK1539115T3 (en)
ES (1) ES2293039T3 (en)
HK (1) HK1072559A1 (en)
HR (1) HRP20050077B1 (en)
IL (1) IL166489A (en)
MX (1) MXPA05001191A (en)
MY (1) MY137049A (en)
NO (1) NO324821B1 (en)
NZ (1) NZ570198A (en)
PE (1) PE20040132A1 (en)
PL (1) PL210119B1 (en)
PT (1) PT1539115E (en)
RU (1) RU2321391C2 (en)
TW (1) TWI363637B (en)
WO (1) WO2004010981A1 (en)
ZA (1) ZA200501641B (en)

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Also Published As

Publication number Publication date
JP4500679B2 (en) 2010-07-14
HK1072559A1 (en) 2005-09-02
BR0313139A (en) 2005-07-05
EP1539115B1 (en) 2007-09-19
NO20050956L (en) 2005-04-27
IL166489A0 (en) 2006-01-15
CY1107096T1 (en) 2012-10-24
CA2494234C (en) 2009-10-27
NO324821B1 (en) 2007-12-10
PT1539115E (en) 2008-01-14
TW200418524A (en) 2004-10-01
TWI363637B (en) 2012-05-11
EP1539115A1 (en) 2005-06-15
MY137049A (en) 2008-12-31
CA2494234A1 (en) 2004-02-05
CN1684670A (en) 2005-10-19
ES2293039T3 (en) 2008-03-16
ZA200501641B (en) 2005-08-31
AU2003256844A1 (en) 2004-02-16
RU2005102105A (en) 2005-08-10
DE60316454D1 (en) 2007-10-31
PE20040132A1 (en) 2004-03-06
RU2321391C2 (en) 2008-04-10
DK1539115T3 (en) 2008-01-28
PL210119B1 (en) 2011-12-30
IL166489A (en) 2014-01-30
AR040721A1 (en) 2005-04-20
JP2005535682A (en) 2005-11-24
WO2004010981A1 (en) 2004-02-05
US20040092534A1 (en) 2004-05-13
HRP20050077A2 (en) 2005-12-31
MXPA05001191A (en) 2005-09-12
NZ570198A (en) 2010-01-29
DE60316454T2 (en) 2008-06-26
KR100699516B1 (en) 2007-03-26
CO5580742A2 (en) 2005-11-30
ATE373472T1 (en) 2007-10-15
PL376258A1 (en) 2005-12-27
KR20050044895A (en) 2005-05-13

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