HRP20010956B1 - Macrolides - Google Patents

Macrolides

Info

Publication number: HRP20010956B1
Authority: HR; Croatia
Prior art keywords: macrolides; azithromycin; monohydrate; stable; processes
Prior art date: 1999-06-29

Application number

HR20010956A

Other languages

English (en)

Croatian (hr)

Inventor

Centellas Victor

Garcia Rafael

Poch Marta

Diago Jose

Ludescher Johannes

Bosch Immaculada

Original Assignee

Biochemie S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-29

Filing date

2001-12-24

Publication date

2010-09-30

1999-06-29 Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en

1999-06-29 Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en

1999-12-20 Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en

2001-12-24 Application filed by Biochemie S.A. filed Critical Biochemie S.A.

2003-08-31 Publication of HRP20010956A2 publication Critical patent/HRP20010956A2/hr

2010-09-30 Publication of HRP20010956B1 publication Critical patent/HRP20010956B1/xx

Links

239000003120 macrolide antibiotic agent Substances 0.000 title 1
229940041033 macrolides Drugs 0.000 title 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 2
229960004099 azithromycin Drugs 0.000 abstract 2
150000004682 monohydrates Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

HR20010956A 1999-06-29 2001-12-24 Macrolides HRP20010956B1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9915218.3A GB9915218D0 (en)	1999-06-29	1999-06-29	Organic compounds
GBGB9915216.7A GB9915216D0 (en)	1999-06-29	1999-06-29	Organic compounds
GBGB9930059.2A GB9930059D0 (en)	1999-12-20	1999-12-20	Organic compounds
PCT/EP2000/005948 WO2001000640A1 (en)	1999-06-29	2000-06-27	Macrolides

Publications (2)

Publication Number	Publication Date
HRP20010956A2 HRP20010956A2 (en)	2003-08-31
HRP20010956B1 true HRP20010956B1 (en)	2010-09-30

Family

ID=27269768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010956A HRP20010956B1 (en)	1999-06-29	2001-12-24	Macrolides

Country Status (10)

Country	Link
US (1)	US6703372B1 (de)
EP (2)	EP1712556B1 (de)
JP (2)	JP4703924B2 (de)
KR (1)	KR100700475B1 (de)
AT (2)	ATE334136T1 (de)
AU (1)	AU5820400A (de)
DE (3)	DE60044515D1 (de)
ES (2)	ES2346782T3 (de)
HR (1)	HRP20010956B1 (de)
WO (1)	WO2001000640A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en)	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
US6528492B1 (en)	2000-07-25	2003-03-04	Instituto De Investigacion En Quimica Aplicada S.C.	Single-step process for preparing 7, 16-deoxy-2-aza-10-0-cladinosil-12-0-desosaminil-4, 5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1) hexadeca-1(2)-en-ona and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) *	2000-07-31	2003-09-16	Sint Quimica Sa	Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
PL207076B1 (pl) *	2000-11-27	2010-10-29	Sandoz Ag	Sposób wytwarzania jednowodzianu azytromycyny
HRP20010301A2 (en) *	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
PT1390377E (pt) *	2001-05-22	2006-06-30	Pfizer Prod Inc	Nova forma cristalina da azitromicina
EP1671978A1 (de) *	2001-05-22	2006-06-21	Pfizer Products Inc.	Neue Kristallforme von Azithromycin
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
EP1455757A2 (de) *	2001-12-21	2004-09-15	Pfizer Products Inc.	Verfahren zur feuchtgranulierung von azithromycin
CN1639181A (zh) *	2002-02-26	2005-07-13	明治制果株式会社	新的15元环氮杂内酯及新的16元环二氮杂内酯衍生物及其制备方法
JP2005522470A (ja) *	2002-04-03	2005-07-28	ハンミファーム．シーオー．，エルティーディー．	アジスロマイシンの製造方法及びそれに用いられる９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの結晶性水和物
ITMI20021209A1 (it) *	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) *	2002-06-20	2002-07-31	Biochemie Gmbh	Organic compounds
US6855813B2 (en)	2002-07-19	2005-02-15	Alembic Limited	Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) *	2002-10-17	2002-11-27	Biochemie Gmbh	Organic compounds
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
EP1648473B1 (de) *	2003-07-24	2009-01-28	PLIVA HRVATSKA d.o.o.	Schnellösliches azithromycin in einzeldosisform
US20060189800A1 (en) *	2003-07-24	2006-08-24	Mitsuru Ohkubo	Indolopyrrolocabazole derivative and antitumor agent
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
JP2008520686A (ja) *	2004-11-17	2008-06-19	スミスクライン・ビーチャム・コーポレイション	新規な抗菌化合物の使用
CN101177441B (zh) *	2007-12-05	2012-05-23	浙江耐司康药业有限公司	一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) *	2008-12-30	2011-09-21	广东东阳光药业有限公司	阿奇霉素一水合物结晶的制备方法
JP2012520268A (ja)	2009-03-13	2012-09-06	ダ・ボルテラ	グラム陰性細菌の除去のための組成物及び方法
CN102417531B (zh) *	2011-12-20	2014-06-11	浙江国邦药业有限公司	一种阿奇霉素一水合物的制备方法
CN105030704B (zh) *	2015-06-29	2018-09-07	石药集团欧意药业有限公司	阿奇霉素片剂及其制备方法
CN110684056B (zh) *	2018-07-05	2021-07-13	青岛农业大学	一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) *	2020-11-19	2022-05-20	江苏威奇达药业有限公司	一种阿奇霉素胺结晶方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0298650A2 (de) *	1987-07-09	1989-01-11	Pfizer Inc.	Azithromycin-Dihydrat
WO1998041532A1 (en) *	1997-03-14	1998-09-24	Biochemie S.A.	Erythromycin a oxime dihydrate
EP0941999A2 (de) *	1998-03-13	1999-09-15	Hovione Inter Ltd.	Herstellung von Azithromycindihydrat
EP0984020A2 (de) *	1998-08-21	2000-03-08	Apotex Inc.	Azithromycinmonohydrat-Isopropanol Clathrate und Methoden zu deren Herstellung
WO2000027856A1 (en) *	1998-11-10	2000-05-18	Biochemie S.A.	Macrolide intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA835204B (en) *	1982-07-19	1985-02-27	Pfizer	N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
ES2122905B1 (es)	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
ATE269350T1 (de) *	1997-07-08	2004-07-15	Biochemie Sa	Solvate von erythromycin a oxim

2000
- 2000-06-27 KR KR1020017016822A patent/KR100700475B1/ko not_active IP Right Cessation
- 2000-06-27 AU AU58204/00A patent/AU5820400A/en not_active Abandoned
- 2000-06-27 US US10/019,500 patent/US6703372B1/en not_active Expired - Lifetime
- 2000-06-27 DE DE60044515T patent/DE60044515D1/de not_active Expired - Fee Related
- 2000-06-27 JP JP2001507048A patent/JP4703924B2/ja not_active Expired - Fee Related
- 2000-06-27 ES ES06117687T patent/ES2346782T3/es not_active Expired - Lifetime
- 2000-06-27 ES ES00943902T patent/ES2267549T3/es not_active Expired - Lifetime
- 2000-06-27 EP EP06117687A patent/EP1712556B1/de not_active Expired - Lifetime
- 2000-06-27 EP EP00943902A patent/EP1189915B1/de not_active Expired - Lifetime
- 2000-06-27 AT AT00943902T patent/ATE334136T1/de not_active IP Right Cessation
- 2000-06-27 DE DE20023815U patent/DE20023815U1/de not_active Expired - Lifetime
- 2000-06-27 WO PCT/EP2000/005948 patent/WO2001000640A1/en active IP Right Grant
- 2000-06-27 AT AT06117687T patent/ATE469910T1/de not_active IP Right Cessation
- 2000-06-27 DE DE60029589T patent/DE60029589T2/de not_active Expired - Lifetime
2001
- 2001-12-24 HR HR20010956A patent/HRP20010956B1/xx not_active IP Right Cessation
2011
- 2011-01-31 JP JP2011017553A patent/JP2011126894A/ja active Pending

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0298650A2 (de) *	1987-07-09	1989-01-11	Pfizer Inc.	Azithromycin-Dihydrat
WO1998041532A1 (en) *	1997-03-14	1998-09-24	Biochemie S.A.	Erythromycin a oxime dihydrate
EP0941999A2 (de) *	1998-03-13	1999-09-15	Hovione Inter Ltd.	Herstellung von Azithromycindihydrat
EP0984020A2 (de) *	1998-08-21	2000-03-08	Apotex Inc.	Azithromycinmonohydrat-Isopropanol Clathrate und Methoden zu deren Herstellung
WO2000027856A1 (en) *	1998-11-10	2000-05-18	Biochemie S.A.	Macrolide intermediates

Also Published As

Publication number	Publication date
DE60044515D1 (de)	2010-07-15
DE60029589T2 (de)	2007-07-19
ES2346782T3 (es)	2010-10-20
EP1712556A1 (de)	2006-10-18
JP4703924B2 (ja)	2011-06-15
JP2003503417A (ja)	2003-01-28
ATE334136T1 (de)	2006-08-15
WO2001000640A1 (en)	2001-01-04
US6703372B1 (en)	2004-03-09
ATE469910T1 (de)	2010-06-15
KR20020016862A (ko)	2002-03-06
DE20023815U1 (de)	2006-06-08
JP2011126894A (ja)	2011-06-30
AU5820400A (en)	2001-01-31
KR100700475B1 (ko)	2007-03-28
EP1189915B1 (de)	2006-07-26
EP1712556B1 (de)	2010-06-02
EP1189915A1 (de)	2002-03-27
ES2267549T3 (es)	2007-03-16
HRP20010956A2 (en)	2003-08-31
DE60029589D1 (de)	2006-09-07

Legal Events

Date	Code	Title	Description
2003-08-31	A1OB	Publication of a patent application
2004-02-19	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2010-09-30	B1PR	Patent granted
2015-05-06	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20150506 Year of fee payment: 16
2017-01-09	PBON	Lapse due to non-payment of renewal fee	Effective date: 20160627

Publication	Publication Date	Title
HRP20010956B1 (en)	2010-09-30	Macrolides
ZA9811939B (en)	2000-06-30	Novel macrolides.
ZA9811940B (en)	2000-06-30	Novel erythromycin derivatives.
HK1047942A1 (en)	2003-03-14	Purine derivatives.
ZA200110208B (en)	2002-12-12	Purine derivatives.
ZA200202849B (en)	2003-06-25	Purine derivatives.
ZA200100670B (en)	2001-08-08	Jackpot system.
ZA99254B (en)	1999-07-16	Benzosulfone derivatives.
HK1034978A1 (en)	2001-11-09	Adenosine derivatives.
PL348333A1 (en)	2002-05-20	Macrolides
ZA985018B (en)	1999-12-10	9-oxime erythromycin derivatives.
ZA200109595B (en)	2003-05-28	13-methyl-erythromycin derivatives.
ZA200103289B (en)	2002-08-28	Novel macrolide antibiotics.
HK1046411A1 (en)	2003-01-10	5-Phenyl-pyrimidine derivatives.
IL134220A0 (en)	2001-04-30	6,9-bridged erythromycin derivatives
ZA200107346B (en)	2002-11-27	Erythromycin derivatives.
HK1034969A1 (en)	2001-11-09	Dihydroxyhexanoic acid derivatives.
HU9901911D0 (en)	1999-08-30	Diaza-spiro[3,5]nanone derivatives
ZA991550B (en)	1999-08-26	Cyclohexanediole derivatives.
SG83135A1 (en)	2001-09-18	Di-or triaza-spiro(4,5)decane derivatives
GB2371457B (en)	2004-05-05	An arrangement for H.323 proxies
HK1046536A1 (en)	2003-01-17	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins.
ZA200004983B (en)	2001-07-19	Lightweight draft arm.
HK1057047A1 (en)	2004-03-12	Processes for preparing erythromycin derivatives and intermediates thereof.
MXPA03000920A (es)	2003-06-24	Derivado de eritromicina y medicamento que comprende lo mismo.