HK1115584A1 - Benzimidazole derivative and use thereof - Google Patents

Benzimidazole derivative and use thereof

Info

Publication number
HK1115584A1
HK1115584A1 HK08105778.9A HK08105778A HK1115584A1 HK 1115584 A1 HK1115584 A1 HK 1115584A1 HK 08105778 A HK08105778 A HK 08105778A HK 1115584 A1 HK1115584 A1 HK 1115584A1
Authority
HK
Hong Kong
Prior art keywords
benzimidazole derivative
benzimidazole
derivative
Prior art date
Application number
HK08105778.9A
Other languages
English (en)
Inventor
Junko Ban
Mami Ojima
Takanobu Kuroita
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of HK1115584A1 publication Critical patent/HK1115584A1/xx

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
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HK08105778.9A 2005-03-30 2008-05-23 Benzimidazole derivative and use thereof HK1115584A1 (en)

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Families Citing this family (12)

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WO2007097451A1 (ja) 2006-02-27 2007-08-30 Takeda Pharmaceutical Company Limited 医薬パッケージ
WO2007097452A1 (ja) * 2006-02-27 2007-08-30 Takeda Pharmaceutical Company Limited 医薬用ブリスターパッケージ
CA2664380C (en) * 2006-09-25 2016-08-23 Takeda Pharmaceutical Company Limited Medicinal package
EP1988091B1 (en) 2007-02-07 2015-06-10 Kyowa Hakko Kirin Co., Ltd. Tricyclic compounds
AU2009277455A1 (en) * 2008-07-31 2010-02-04 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition
JP5559689B2 (ja) 2008-08-06 2014-07-23 協和発酵キリン株式会社 3環系化合物
UY32126A (es) 2008-09-25 2010-04-30 Takeda Pharmaceutical Composición farmacéutica sólida
JP2014505097A (ja) * 2011-02-08 2014-02-27 ジュビラント ライフ サイエンセズ リミテッド アジルサルタンメドキソミルの改良製造方法
CZ304252B6 (cs) * 2011-04-11 2014-01-29 Zentiva, K. S. Způsob výroby 2-ethoxy-1-((2´-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylátů a jejich převedení na azilsartan
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN102827153B (zh) * 2011-06-14 2016-10-05 江苏豪森药业集团有限公司 阿齐沙坦的晶型及其制备方法
JP6281735B2 (ja) * 2013-03-19 2018-02-21 トーアエイヨー株式会社 急性心不全治療薬の評価方法、及び、急性心不全モデルの作製方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US6004989A (en) * 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
US5594003A (en) * 1991-02-06 1997-01-14 Dr. Karl Thomae Gmbh Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists
US5602127A (en) * 1991-02-06 1997-02-11 Karl Thomae Gmbh (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists
US5591762A (en) * 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4408497A1 (de) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1997037688A2 (en) * 1996-04-05 1997-10-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity
IL137979A0 (en) * 1998-03-04 2001-10-31 Takeda Chemical Industries Ltd Production, release preparation for aii antagonist-sustained and use thereof
RS50340B (sr) * 1999-06-23 2009-11-10 Sanofi-Aventis Deutschland Gmbh., Supstituisani benzimidazoli
CA2468827A1 (en) * 2001-12-03 2003-06-12 Takeda Chemical Industries, Ltd. Insulin resistance improving agents
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof

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HRP20080552A9 (en) 2009-08-31
NO20075399L (no) 2007-12-19
US20090054502A1 (en) 2009-02-26
DK1863801T3 (da) 2010-11-15
NZ562887A (en) 2010-10-29
KR20070116648A (ko) 2007-12-10
BRPI0608944A2 (pt) 2010-11-16
RS20080510A (en) 2009-07-15
HRP20080552A2 (en) 2009-03-31
RU2407742C2 (ru) 2010-12-27
CY1111168T1 (el) 2015-06-11
JP4795362B2 (ja) 2011-10-19
IL185726A (en) 2012-07-31
AU2006231418B2 (en) 2011-10-13
MA29438B1 (fr) 2008-05-02
AR055755A1 (es) 2007-09-05
WO2006107062A2 (en) 2006-10-12
CA2602624A1 (en) 2006-10-12
IL185726A0 (en) 2008-01-06
MEP33308A (en) 2010-10-10
JP2008534434A (ja) 2008-08-28
DE602006017183D1 (de) 2010-11-11
AU2006231418A1 (en) 2006-10-12
PE20061195A1 (es) 2006-12-21
TW200724539A (en) 2007-07-01
US20120172401A1 (en) 2012-07-05
GEP20115138B (en) 2011-01-10
SI1863801T1 (sl) 2010-12-31
MY146254A (en) 2012-07-31
PL1863801T3 (pl) 2011-03-31
JP2011190265A (ja) 2011-09-29
PT1863801E (pt) 2010-11-19
RU2007139928A (ru) 2009-05-10
CR9432A (es) 2008-02-04
EP1863801B1 (en) 2010-09-29
WO2006107062A3 (en) 2006-12-14
EP1863801A2 (en) 2007-12-12

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