HK1089443A1 - Imidazol-4-yl-ethynyl-pyridine derivatives - Google Patents

Imidazol-4-yl-ethynyl-pyridine derivatives

Info

Publication number
HK1089443A1
HK1089443A1 HK06109889A HK06109889A HK1089443A1 HK 1089443 A1 HK1089443 A1 HK 1089443A1 HK 06109889 A HK06109889 A HK 06109889A HK 06109889 A HK06109889 A HK 06109889A HK 1089443 A1 HK1089443 A1 HK 1089443A1
Authority
HK
Hong Kong
Prior art keywords
imidazol
ethynyl
pyridine derivatives
pyridine
derivatives
Prior art date
Application number
HK06109889A
Inventor
Buettelmann Bernd
Ceccarelli Simona Maria
Jaeschke Georg
Kolczewski Sabine
Porter Richard Hugh Philip
Vieira Eric
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1089443A1 publication Critical patent/HK1089443A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06109889A 2003-03-10 2006-09-06 Imidazol-4-yl-ethynyl-pyridine derivatives HK1089443A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03004952 2003-03-10
PCT/EP2004/002276 WO2004080998A1 (en) 2003-03-10 2004-03-05 Imidazol-4-yl-ethynyl-pyridine derivatives

Publications (1)

Publication Number Publication Date
HK1089443A1 true HK1089443A1 (en) 2006-12-01

Family

ID=32981724

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109889A HK1089443A1 (en) 2003-03-10 2006-09-06 Imidazol-4-yl-ethynyl-pyridine derivatives

Country Status (31)

Country Link
US (1) US7153874B2 (en)
EP (1) EP1606277B8 (en)
JP (1) JP4404896B2 (en)
KR (1) KR100742019B1 (en)
CN (1) CN100358889C (en)
AR (1) AR043501A1 (en)
AT (1) ATE395345T1 (en)
AU (1) AU2004220382B2 (en)
BR (1) BRPI0408093A (en)
CA (1) CA2516682C (en)
CL (1) CL2004000449A1 (en)
CO (1) CO5601027A2 (en)
DE (1) DE602004013746D1 (en)
DK (1) DK1606277T3 (en)
ES (1) ES2305739T3 (en)
HK (1) HK1089443A1 (en)
HR (1) HRP20050774A2 (en)
IL (1) IL170129A (en)
MX (1) MXPA05009524A (en)
MY (1) MY135491A (en)
NO (1) NO20054136L (en)
NZ (1) NZ541643A (en)
PA (1) PA8597301A1 (en)
PE (1) PE20041061A1 (en)
PL (1) PL1606277T3 (en)
PT (1) PT1606277E (en)
RU (1) RU2342383C2 (en)
SI (1) SI1606277T1 (en)
TW (1) TWI292318B (en)
WO (1) WO2004080998A1 (en)
ZA (1) ZA200506834B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7452909B2 (en) * 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
CN1960984B (en) * 2004-06-01 2010-05-12 弗·哈夫曼-拉罗切有限公司 Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
EA011722B1 (en) 2004-06-01 2009-04-28 Ф.Хоффманн-Ля Рош Аг Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
DE102006011574A1 (en) * 2006-03-10 2007-10-31 Grünenthal GmbH Substituted imidazo [2,1-b] thiazole compounds and their use for the preparation of medicaments
JP2009536669A (en) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド Neurogenesis by angiotensin regulation
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
JP2010502722A (en) * 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド Combinations containing 4-acylaminopyridine derivatives
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
RU2460728C2 (en) 2006-12-21 2012-09-10 Ф. Хоффманн-Ля Рош Аг 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1h-imidazol-4-ylethinyl]-pyridine monosulphate salt and crystalline form thereof, pharmaceutical composition containing said salt and production method thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8334287B2 (en) 2009-07-17 2012-12-18 Hoffmann-La Roche Inc. Imidazoles
US8586581B2 (en) 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
EA022019B1 (en) 2011-04-26 2015-10-30 Ф.Хоффманн-Ля Рош Аг ETHYNYL DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE mGluR5
UA116023C2 (en) 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Ethynyl derivatives as metabotropic glutamate receptor antagonists
EP3400220B1 (en) * 2016-01-05 2021-03-24 Hua Medicine (Shanghai) Ltd. Pyrazole derivatives
KR102515694B1 (en) 2017-01-10 2023-03-29 바이엘 악티엔게젤샤프트 Heterocycle derivatives as pest control agents
UY37557A (en) 2017-01-10 2018-07-31 Bayer Ag HETEROCYCLIC DERIVATIVES AS PESTICIDES
JP2023504177A (en) * 2019-12-02 2023-02-01 エフ．ホフマン－ラ ロシュ アーゲー Alkynyl-(heteroaryl)-carboxamide HCN1 inhibitors
CN111416154B (en) * 2020-05-22 2021-08-06 松山湖材料实验室 Silicon-based pyridine additive for high-voltage lithium ion battery electrolyte, electrolyte and battery
AU2022251771A1 (en) 2021-03-27 2023-09-21 Syngenta Crop Protection Ag Microbiocidal isonicotinic amide derivatives
CN118265702A (en) 2021-11-19 2024-06-28 先正达农作物保护股份公司 Microbiocidal isonicotinamide derivatives
WO2024132901A1 (en) 2022-12-19 2024-06-27 Syngenta Crop Protection Ag Microbiocidal pyridazine dihydrooxadiazine derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303199A (en) * 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (en) 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazole compounds and their manufacturing process
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
US4711962A (en) * 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
CA2060656A1 (en) 1989-06-30 1990-12-31 Robert John Ardecky Substituted imidazoles
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
AU741532B2 (en) 1997-08-14 2001-12-06 F. Hoffmann-La Roche Ag Heterocyclic vinylethers against neurological disorders
CA2383524C (en) 1999-08-31 2010-09-28 Merck & Co., Inc. Thiazolyl alkynyl compounds and methods of use thereof
SK8402003A3 (en) 2000-12-04 2004-04-06 Hoffmann La Roche Phenylethenyl or phenylethinyl derivatives as glutamate receptor or antagonists
WO2003053922A2 (en) * 2001-12-19 2003-07-03 Merck & Co., Inc. Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5

Also Published As

Publication number Publication date
CN100358889C (en) 2008-01-02
DE602004013746D1 (en) 2008-06-26
TWI292318B (en) 2008-01-11
NO20054136D0 (en) 2005-09-06
EP1606277B8 (en) 2008-10-15
JP2006519802A (en) 2006-08-31
TW200423935A (en) 2004-11-16
MY135491A (en) 2008-04-30
AU2004220382A1 (en) 2004-09-23
EP1606277A1 (en) 2005-12-21
RU2342383C2 (en) 2008-12-27
CL2004000449A1 (en) 2005-01-07
ES2305739T3 (en) 2008-11-01
ATE395345T1 (en) 2008-05-15
AR043501A1 (en) 2005-08-03
CO5601027A2 (en) 2006-01-31
US20040229917A1 (en) 2004-11-18
SI1606277T1 (en) 2008-08-31
CA2516682C (en) 2010-02-02
AU2004220382B2 (en) 2007-08-02
PA8597301A1 (en) 2004-09-16
PL1606277T3 (en) 2008-10-31
MXPA05009524A (en) 2005-10-18
ZA200506834B (en) 2006-05-31
BRPI0408093A (en) 2006-02-14
PT1606277E (en) 2008-07-08
PE20041061A1 (en) 2005-01-22
HRP20050774A2 (en) 2006-09-30
EP1606277B1 (en) 2008-05-14
NO20054136L (en) 2005-09-26
WO2004080998A1 (en) 2004-09-23
CN1759111A (en) 2006-04-12
DK1606277T3 (en) 2008-08-18
JP4404896B2 (en) 2010-01-27
KR100742019B1 (en) 2007-07-23
IL170129A (en) 2013-02-28
CA2516682A1 (en) 2004-09-23
NZ541643A (en) 2008-03-28
RU2005131165A (en) 2007-04-20
US7153874B2 (en) 2006-12-26
KR20050109074A (en) 2005-11-17

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120305