GR76032B - - Google Patents

Info

Publication number
GR76032B
GR76032B GR67412A GR820167412A GR76032B GR 76032 B GR76032 B GR 76032B GR 67412 A GR67412 A GR 67412A GR 820167412 A GR820167412 A GR 820167412A GR 76032 B GR76032 B GR 76032B
Authority
GR
Greece
Prior art keywords
hydrogen
imidazodiazepines
benzodiazepines
trifluoromethyl
cyano
Prior art date
Application number
GR67412A
Other languages
English (en)
Inventor
Walter Hunkeler
Emilio Kyburz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of GR76032B publication Critical patent/GR76032B/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR67412A 1981-02-27 1982-02-25 GR76032B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH134081 1981-02-27

Publications (1)

Publication Number Publication Date
GR76032B true GR76032B (el) 1984-08-03

Family

ID=4208189

Family Applications (1)

Application Number Title Priority Date Filing Date
GR67412A GR76032B (el) 1981-02-27 1982-02-25

Country Status (27)

Country Link
US (1) US4352817A (el)
EP (1) EP0059389B1 (el)
JP (1) JPS57156488A (el)
KR (1) KR830009104A (el)
AT (1) ATE10745T1 (el)
AU (1) AU551811B2 (el)
BR (1) BR8200949A (el)
CA (1) CA1184176A (el)
DE (1) DE3261496D1 (el)
DK (1) DK87182A (el)
ES (3) ES8304982A1 (el)
FI (1) FI73431C (el)
GB (1) GB2093842B (el)
GR (1) GR76032B (el)
HU (1) HU185089B (el)
IE (1) IE52696B1 (el)
IL (1) IL65072A (el)
MC (1) MC1441A1 (el)
NO (1) NO157377C (el)
NZ (1) NZ199796A (el)
OA (1) OA07010A (el)
PH (1) PH18255A (el)
PT (1) PT74505B (el)
YU (1) YU25282A (el)
ZA (1) ZA821129B (el)
ZM (1) ZM482A1 (el)
ZW (1) ZW3082A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
NZ210850A (en) * 1984-01-19 1988-10-28 Hoffmann La Roche Imidazodiazepine derivatives and pharmaceutical compositions
DE3689096T2 (de) * 1985-07-09 1994-01-27 Nippon Petrochemicals Co Ltd Feuerhemmende Polyolefinzusammensetzung.
DE3763015D1 (de) * 1986-03-03 1990-07-12 Ube Industries Vertikale spritzgussmaschine.
ZA881538B (en) * 1987-03-10 1988-09-12 F. Hoffmann-La Roche & Co. Aktiengesellschaft Imidazodiazepine derivatives
CA1327008C (en) * 1988-01-15 1994-02-15 Walter Merz Anti-psychotic imidazobenzodiazepine
DE58902867D1 (de) * 1988-08-05 1993-01-14 Hoffmann La Roche Radioaktiv markierte benzodiazepinderivate.
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US5109013A (en) * 1990-06-06 1992-04-28 A. H. Robins Company, Incorporated 2-(2-substituted aminoethyl)-1,4-dialkyl-3,4-dihydro-1H-1,3,5]triazepino[3,2-a]benzimidazol-5(2H)-ones as muscle relaxants
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
JO2259B1 (en) * 1999-05-12 2004-10-07 اف. هوفمان- لاروش أيه جي‏ Method for the manufacture of diazapine derivatives
WO2007018660A2 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic imidazobenzodiazepine derivatives to treat memory deficits
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
KR101589314B1 (ko) 2007-08-20 2016-01-28 에보텍 인터내셔널 게엠베하 수면 장애의 치료
CN113087713B (zh) * 2021-03-29 2022-10-04 中国人民解放军军事科学院军事医学研究院 一类苯并二氮䓬衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2609486A1 (de) * 1975-08-07 1977-05-12 Hoffmann La Roche Imidazo eckige klammer auf 1,5-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepin-verbindungen und verfahren zu ihrer herstellung
GB1600600A (en) * 1977-03-10 1981-10-21 Diamond Shamrock Chem Plasticiser compositions for use with synthetic resin polymers
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives

Also Published As

Publication number Publication date
YU25282A (en) 1989-08-31
OA07010A (fr) 1983-08-31
JPS57156488A (en) 1982-09-27
ZM482A1 (en) 1982-11-22
GB2093842A (en) 1982-09-08
AU8066682A (en) 1982-09-02
FI73431C (fi) 1987-10-09
NZ199796A (en) 1985-10-11
US4352817A (en) 1982-10-05
PT74505B (en) 1984-11-26
ZW3082A1 (en) 1982-09-29
CA1184176A (en) 1985-03-19
IL65072A (en) 1985-12-31
IL65072A0 (en) 1982-04-30
ES518263A0 (es) 1984-06-01
DK87182A (da) 1982-08-28
ES518262A0 (es) 1984-06-01
ES509924A0 (es) 1983-04-01
ES8304982A1 (es) 1983-04-01
AU551811B2 (en) 1986-05-15
PH18255A (en) 1985-05-13
KR830009104A (ko) 1983-12-17
IE52696B1 (en) 1988-01-20
EP0059389B1 (de) 1984-12-12
IE820420L (en) 1982-08-27
EP0059389A1 (de) 1982-09-08
ES8405008A1 (es) 1984-06-01
FI73431B (fi) 1987-06-30
NO157377C (no) 1988-03-05
MC1441A1 (fr) 1982-12-06
ATE10745T1 (de) 1984-12-15
DE3261496D1 (en) 1985-01-24
NO820623L (no) 1982-08-30
ZA821129B (en) 1983-01-26
BR8200949A (pt) 1983-01-04
NO157377B (no) 1987-11-30
PT74505A (en) 1982-03-01
ES8405009A1 (es) 1984-06-01
HU185089B (en) 1984-11-28
GB2093842B (en) 1984-10-17
FI820199L (fi) 1982-08-28

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