GR75872B - - Google Patents
Info
- Publication number
- GR75872B GR75872B GR67181A GR820167181A GR75872B GR 75872 B GR75872 B GR 75872B GR 67181 A GR67181 A GR 67181A GR 820167181 A GR820167181 A GR 820167181A GR 75872 B GR75872 B GR 75872B
- Authority
- GR
- Greece
- Prior art keywords
- carbon atoms
- benzo
- bears
- unsubstituted
- alkylene
- Prior art date
Links
- -1 hydroxy, amino, nitro, carbamoyl Chemical group 0.000 abstract 9
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8103131 | 1981-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR75872B true GR75872B (el) | 1984-08-02 |
Family
ID=10519390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR67181A GR75872B (el) | 1981-02-02 | 1982-02-02 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4399138A (el) |
| EP (1) | EP0057572B1 (el) |
| JP (1) | JPS57163370A (el) |
| KR (1) | KR830009069A (el) |
| AT (1) | ATE14576T1 (el) |
| AU (1) | AU550763B2 (el) |
| CA (1) | CA1198110A (el) |
| DE (1) | DE3264964D1 (el) |
| DK (1) | DK43382A (el) |
| ES (1) | ES509250A0 (el) |
| FI (1) | FI820266L (el) |
| GR (1) | GR75872B (el) |
| HU (1) | HU187634B (el) |
| IE (1) | IE52345B1 (el) |
| IL (1) | IL64890A (el) |
| NO (1) | NO820291L (el) |
| NZ (1) | NZ199627A (el) |
| PH (1) | PH18070A (el) |
| PT (1) | PT74373B (el) |
| YU (1) | YU22082A (el) |
| ZA (1) | ZA82562B (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0086564B1 (en) * | 1982-01-29 | 1985-11-21 | Imperial Chemical Industries Plc | Alkanolamine derivatives |
| US4604394A (en) * | 1984-10-01 | 1986-08-05 | Merck & Co., Inc. | Antiarrhythmic compositions and method |
| GB8810933D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| GB8810934D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| US4803206A (en) * | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
| GB8812342D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
| GB8812343D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
| UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472847A (en) * | 1966-08-25 | 1969-10-14 | Merck & Co Inc | Conversion of pyrazinoylcyanamides to pyrazinoylguanidines |
| US3577418A (en) * | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
| US3573306A (en) * | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
| US3544568A (en) * | 1969-03-18 | 1970-12-01 | Merck & Co Inc | 3-amino-5,6-substituted pyrazinamides |
| US3655663A (en) * | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
| US3948895A (en) * | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| GB1521471A (en) * | 1974-06-05 | 1978-08-16 | Randall & Son Ltd J | Token-deposit locks |
| US4115409A (en) * | 1975-12-05 | 1978-09-19 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| GB1540463A (en) * | 1976-10-07 | 1979-02-14 | Ici Ltd | Alkanolamine derivatives |
| US4219561A (en) * | 1977-09-22 | 1980-08-26 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
-
1982
- 1982-01-27 IE IE175/82A patent/IE52345B1/en unknown
- 1982-01-27 FI FI820266A patent/FI820266L/fi not_active Application Discontinuation
- 1982-01-28 AU AU79946/82A patent/AU550763B2/en not_active Ceased
- 1982-01-28 IL IL64890A patent/IL64890A/xx unknown
- 1982-01-28 DE DE8282300443T patent/DE3264964D1/de not_active Expired
- 1982-01-28 AT AT82300443T patent/ATE14576T1/de not_active IP Right Cessation
- 1982-01-28 ZA ZA82562A patent/ZA82562B/xx unknown
- 1982-01-28 EP EP82300443A patent/EP0057572B1/en not_active Expired
- 1982-01-29 HU HU82270A patent/HU187634B/hu unknown
- 1982-01-29 PH PH26799A patent/PH18070A/en unknown
- 1982-02-01 NZ NZ199627A patent/NZ199627A/en unknown
- 1982-02-01 CA CA000395265A patent/CA1198110A/en not_active Expired
- 1982-02-01 DK DK43382A patent/DK43382A/da not_active Application Discontinuation
- 1982-02-01 NO NO820291A patent/NO820291L/no unknown
- 1982-02-01 YU YU00220/82A patent/YU22082A/xx unknown
- 1982-02-02 JP JP57014428A patent/JPS57163370A/ja active Pending
- 1982-02-02 ES ES509250A patent/ES509250A0/es active Granted
- 1982-02-02 US US06/344,969 patent/US4399138A/en not_active Expired - Fee Related
- 1982-02-02 PT PT74373A patent/PT74373B/pt unknown
- 1982-02-02 GR GR67181A patent/GR75872B/el unknown
- 1982-02-02 KR KR1019820000429A patent/KR830009069A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA82562B (en) | 1982-12-29 |
| IE52345B1 (en) | 1987-09-16 |
| EP0057572A1 (en) | 1982-08-11 |
| PT74373A (en) | 1982-03-01 |
| JPS57163370A (en) | 1982-10-07 |
| ATE14576T1 (de) | 1985-08-15 |
| NO820291L (no) | 1982-08-03 |
| PH18070A (en) | 1985-03-18 |
| HU187634B (en) | 1986-02-28 |
| IE820175L (en) | 1982-08-02 |
| DE3264964D1 (de) | 1985-09-05 |
| FI820266L (fi) | 1982-08-03 |
| DK43382A (da) | 1982-08-03 |
| EP0057572B1 (en) | 1985-07-31 |
| ES8304952A1 (es) | 1983-03-16 |
| YU22082A (en) | 1985-04-30 |
| IL64890A (en) | 1986-09-30 |
| IL64890A0 (en) | 1982-03-31 |
| AU7994682A (en) | 1982-08-12 |
| AU550763B2 (en) | 1986-04-10 |
| CA1198110A (en) | 1985-12-17 |
| US4399138A (en) | 1983-08-16 |
| PT74373B (en) | 1983-07-14 |
| KR830009069A (ko) | 1983-12-17 |
| ES509250A0 (es) | 1983-03-16 |
| NZ199627A (en) | 1984-11-09 |
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