GB963408A - New derivatives of cardenolides and bufadienolides and processes for their manufacture - Google Patents

New derivatives of cardenolides and bufadienolides and processes for their manufacture

Info

Publication number
GB963408A
GB963408A GB799662A GB799662A GB963408A GB 963408 A GB963408 A GB 963408A GB 799662 A GB799662 A GB 799662A GB 799662 A GB799662 A GB 799662A GB 963408 A GB963408 A GB 963408A
Authority
GB
United Kingdom
Prior art keywords
radical
steroids
general formula
formula
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB799662A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Merck KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG, Merck KGaA filed Critical E Merck AG
Publication of GB963408A publication Critical patent/GB963408A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention comprises steroids of the general formula: <FORM:0963408/C1/1> wherein R1 represents hydrogen or an acyl or glycoside radical, R2 represents a H, b H or b OH, R3 to R6 represent hydrogen or a hydroxy radical, R7 represents a radical of the formula: <FORM:0963408/C1/2> and R8 represents an optionally substituted alkyl, cyclohexyl, aryl, aralkyl or hydroxyalkyl radical, and wherein the dotted line between the 4- and 5-positions denotes the optional presence of a double bond, and a process for the preparation of steroidal Schiff's bases derived from steroids of the 19-oxo-cardenolide and 19-oxo bufadienolide series as well as their 3-glycosides and esters by reacting steroids of the said series containing an aldehyde group at C10 with a nitrogen containing compound of the formula R-N=X wherein X represents H, H or a lower alkylidene radical and R has the same significance as R8 above, and isolating the derived reaction product from the reaction mixture under approximately neutral conditions. The preferred reactants for the above process have the general formula: <FORM:0963408/C1/3> wherein the dotted line and R1 to R7 have the above significance. Therapeutic compositions useful as cardioactive pharmaceutical agents contain steroids of the first general formula above. The compositions may be administered orally and may be in the form of tablets, pills, dragees and suppositories.
GB799662A 1961-03-04 1962-03-01 New derivatives of cardenolides and bufadienolides and processes for their manufacture Expired GB963408A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM48272A DE1165593B (en) 1961-03-04 1961-03-04 Process for the production of Schiff bases from cardenolides or their 3-glycosides or 3-esters

Publications (1)

Publication Number Publication Date
GB963408A true GB963408A (en) 1964-07-08

Family

ID=7306178

Family Applications (1)

Application Number Title Priority Date Filing Date
GB799662A Expired GB963408A (en) 1961-03-04 1962-03-01 New derivatives of cardenolides and bufadienolides and processes for their manufacture

Country Status (4)

Country Link
DE (1) DE1165593B (en)
FR (1) FR1774M (en)
GB (1) GB963408A (en)
NL (1) NL107562C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014343A1 (en) * 2000-08-17 2002-02-21 Terness, Peter Bufadienolide derivatives and use as immunosuppressive, antiinflammatory and analgesic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014343A1 (en) * 2000-08-17 2002-02-21 Terness, Peter Bufadienolide derivatives and use as immunosuppressive, antiinflammatory and analgesic agents

Also Published As

Publication number Publication date
NL107562C (en) 1963-09-16
FR1774M (en) 1963-04-16
DE1165593B (en) 1964-03-19

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