GB901107A - Therapeutic composition and method of preparing same - Google Patents

Therapeutic composition and method of preparing same

Info

Publication number
GB901107A
GB901107A GB2228959A GB2228959A GB901107A GB 901107 A GB901107 A GB 901107A GB 2228959 A GB2228959 A GB 2228959A GB 2228959 A GB2228959 A GB 2228959A GB 901107 A GB901107 A GB 901107A
Authority
GB
United Kingdom
Prior art keywords
sodium
magnesium
oxytetracycline
tetracycline
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2228959A
Inventor
Philip Newton Gordon
Charles Robert Stephens Jr
Melvin Mackenzie Noseworthy
Fred Wilson Teare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Priority to GB2228959A priority Critical patent/GB901107A/en
Publication of GB901107A publication Critical patent/GB901107A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A therapeutic composition comprises a solution of at least one of the following antibiotic salts: magnesium, calcium or aluminium tetracycline salt or a magnesium, calcium aluminium or zinc oxytetracycline salt in one or more of the following polyhydric aliphatic alcohol solvents: glycerine, polyethylene glycol or propylene glycol, the molar ratio of metal to antibiotic being about 3 : 1 in the case of tetracycline and from 1 : 3 to 3 : 1 in the case of oxytetracycline and the pH of the solution being from 7 to 10. The metal tetracycline or oxtetracycline salts may be prepared in situ and mixed salts of two metals may be employed e.g. calcium, magnesium oxytetracycline or magnesium zinc oxtetracycline. A non-toxic alkanol, e.g. sorbitol or ethanol may be added in an amount of up to 20% of the solutions. The compositions are administered (a) intramuscularly or when diluted with water intravenously, (b) as otic or veterinary opthalmic solutions and in humans as otic solutions, mouthwashes or disinfectants, or (c) as salves or suppositories, using as a solvent a high molecular weight polyethylene glycol, e.g. the carbowaxes. The compositions may contain additionally (a) antibiotics, e.g. streptomycin, polymixin B sulphate, carbomycin or oleandomycin, (b) steroid hormones, e.g. prednisolone, cortisone or hydrocortisone, (c) buffering agents and other stabilizers, e.g. ascorbic acid, triethanolamine, diethanolamine, sodium phosphite, sodium bisulphite and sodium formaldehyde sulphorylate, (d) colouring and flavouring agents, e.g. sodium cyclamate, sodium saccharin, sodium ascorbate, menthol, sodium sucaryl, saccharin, sulphosalicylic acid and benzocain.
GB2228959A 1959-06-29 1959-06-29 Therapeutic composition and method of preparing same Expired GB901107A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2228959A GB901107A (en) 1959-06-29 1959-06-29 Therapeutic composition and method of preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2228959A GB901107A (en) 1959-06-29 1959-06-29 Therapeutic composition and method of preparing same

Publications (1)

Publication Number Publication Date
GB901107A true GB901107A (en) 1962-07-11

Family

ID=10176976

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2228959A Expired GB901107A (en) 1959-06-29 1959-06-29 Therapeutic composition and method of preparing same

Country Status (1)

Country Link
GB (1) GB901107A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40086E1 (en) 1991-10-04 2008-02-19 Wyeth Holdings Corporation Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
WO2008118744A1 (en) * 2007-03-23 2008-10-02 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
WO2010114680A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
US7879828B2 (en) 2005-03-14 2011-02-01 Wyeth Llc Tigecycline compositions and methods of preparation
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20150094282A1 (en) * 2010-05-12 2015-04-02 Rempex Pharmaceuticals, Inc. Tetracycline compositions
WO2016154232A3 (en) * 2015-03-23 2016-12-08 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40086E1 (en) 1991-10-04 2008-02-19 Wyeth Holdings Corporation Method for treating bacterial infection with novel 7-substituted-9-substituted amino 6-demethyl-6-deoxytetracyclines
US9254328B2 (en) 2005-03-14 2016-02-09 Wyeth Llc Tigecycline compositions and methods of preparation
US8975242B2 (en) 2005-03-14 2015-03-10 Wyeth Llc Tigecycline compositions and methods of preparation
US9694078B2 (en) 2005-03-14 2017-07-04 Wyeth Llc Tigecycline compositions and methods of preparation
US7879828B2 (en) 2005-03-14 2011-02-01 Wyeth Llc Tigecycline compositions and methods of preparation
US10588975B2 (en) 2005-03-14 2020-03-17 Wyeth Llc Tigecycline compositions and methods of preparation
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US10987357B2 (en) 2005-05-18 2021-04-27 Horizon Orphan, LLC Aerosolized fluoroquinolones and uses thereof
AU2008231033B2 (en) * 2007-03-23 2012-08-30 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
EA016206B1 (en) * 2007-03-23 2012-03-30 Моликьюлар Рисерч Сентер, Инк. Composition and method for treating anti-inflammatory disorders
JP2010522240A (en) * 2007-03-23 2010-07-01 モレキュラー リサーチ センター インコーポレイテッド Compositions and methods for treating inflammation
WO2008118744A1 (en) * 2007-03-23 2008-10-02 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US9326936B2 (en) 2008-10-07 2016-05-03 Raptor Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10149854B2 (en) 2008-10-07 2018-12-11 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US11020481B2 (en) 2008-10-07 2021-06-01 Horizon Orphan Llc Topical use of levofloxacin for reducing lung inflammation
US10722519B2 (en) 2008-10-07 2020-07-28 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US9717738B2 (en) 2008-10-07 2017-08-01 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
WO2010114680A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10792289B2 (en) 2009-09-04 2020-10-06 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10231975B2 (en) 2009-09-04 2019-03-19 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US11944634B2 (en) 2010-05-12 2024-04-02 Melinta Subsidiary Corp. Tetracycline compositions
US9744179B2 (en) 2010-05-12 2017-08-29 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US9278105B2 (en) 2010-05-12 2016-03-08 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US9084802B2 (en) 2010-05-12 2015-07-21 Rempex Pharmaceuticals, Inc. Tetracycline compositions
US20150094282A1 (en) * 2010-05-12 2015-04-02 Rempex Pharmaceuticals, Inc. Tetracycline compositions
WO2016154232A3 (en) * 2015-03-23 2016-12-08 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
US10881672B2 (en) 2015-03-23 2021-01-05 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
AU2016235237B2 (en) * 2015-03-23 2021-03-11 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
CN107708665A (en) * 2015-03-23 2018-02-16 贝尔生物制药有限公司 Medicinal Fourth Ring promotor composition for dermatological use
US10391108B2 (en) 2015-03-23 2019-08-27 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
CN107708665B (en) * 2015-03-23 2022-07-22 贝尔生物制药有限公司 Pharmaceutical tetracycline compositions for dermatological use
US9918998B2 (en) 2015-03-23 2018-03-20 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use

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