GB895027A - Therapeutic tetracycline compositions - Google Patents

Therapeutic tetracycline compositions

Info

Publication number
GB895027A
GB895027A GB20925/60A GB2092560A GB895027A GB 895027 A GB895027 A GB 895027A GB 20925/60 A GB20925/60 A GB 20925/60A GB 2092560 A GB2092560 A GB 2092560A GB 895027 A GB895027 A GB 895027A
Authority
GB
United Kingdom
Prior art keywords
hydrochloride
tetracycline
acid
pyrrolidinylmethyl
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20925/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB895027A publication Critical patent/GB895027A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Non-toxic acid addition salts of N-(1-pyrrolidinylmethyl) tetracycline are prepared by reacting the tetracycline base with the appropriate acid. Specified salts are the hydrochloride, sulphate, sulphamate, tartrate, hydrobromate, hydriodate, glycolate, citrate, maleate, phosphate, polyimido-phosphate, succinate, acetate and ascorbate. Specifications 809,585 and 817,180 are referred to.ALSO:A substantially anhydrous therapeutic composition for intramuscular injection when dissolved in sterile water or saline, comprises N-(1-pyrrolidinylmethyl) tetracycline, or a non-toxic salt thereof, and a non-toxic acidifying agent in a sufficient amount to produce a pH of not more than 4 when the mixture is dissolved for use. The acidifying agent may be (a) an a -hydroxy-carboxylic acid containing no elements other than carbon, hydrogen and oxygen, e.g. citric, gluconic, tartaric, maleic, malic, ascorbic, mandelic and pyruvic acids; (b) carbamide phosphoric acid; (c) glycine hydrochloride; (d) glutamic acid hydrochloride or (e) sulphamic acid. Suitable salts of N - (1 - pyrrolidinylmethyl) tetracycline are the hydrochloride, sulphate, sulphamate, tartrate, hydrobromate, hydriodate, glycolate, citrate, maleate, phosphate, polyimidophosphate, succinate, acetate and ascorbate. A local anaesthetic such as procaine hydrochloride and lignocaine hydrochloride may also be present. Mixtures providing a pH of 3 to 4 and especially pH 3.4 are preferred. The preparations provide high blood levels of tetracycline. Specifications 809,585 and 817,180 are referred to.
GB20925/60A 1959-08-03 1960-06-14 Therapeutic tetracycline compositions Expired GB895027A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US895027XA 1959-08-03 1959-08-03

Publications (1)

Publication Number Publication Date
GB895027A true GB895027A (en) 1962-04-26

Family

ID=22217997

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20925/60A Expired GB895027A (en) 1959-08-03 1960-06-14 Therapeutic tetracycline compositions

Country Status (1)

Country Link
GB (1) GB895027A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2124499A1 (en) * 1971-02-05 1972-09-22 Squibb & Sons Inc
GB2246296A (en) * 1990-07-25 1992-01-29 Sandoz Ltd Stabilised compositions
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
WO2011141708A3 (en) * 2010-05-14 2012-01-19 Hovione Inter Limited New particles of tetracyclines and protecting agent

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2124499A1 (en) * 1971-02-05 1972-09-22 Squibb & Sons Inc
GB2246296A (en) * 1990-07-25 1992-01-29 Sandoz Ltd Stabilised compositions
GB2246296B (en) * 1990-07-25 1994-04-06 Sandoz Ltd Stabilised compositions containing an ACE inhibitor and a hydrochloric acid donor
US6300362B1 (en) 1990-07-25 2001-10-09 Novartis Ag (Formerly Sandoz Ltd.) Stabilized pharmaceutical compositions comprising acid donors
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
US6509350B2 (en) 1990-07-25 2003-01-21 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
US6790861B2 (en) 1990-07-25 2004-09-14 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
WO2011141708A3 (en) * 2010-05-14 2012-01-19 Hovione Inter Limited New particles of tetracyclines and protecting agent
US9072679B2 (en) 2010-05-14 2015-07-07 Hovione Inter Limited Particles of tetracyclines and protecting agent

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