GB862721A - Dialkylaminoethyl derivatives of salicylamides - Google Patents

Dialkylaminoethyl derivatives of salicylamides

Info

Publication number
GB862721A
GB862721A GB20835/59D GB2083559D GB862721A GB 862721 A GB862721 A GB 862721A GB 20835/59 D GB20835/59 D GB 20835/59D GB 2083559 D GB2083559 D GB 2083559D GB 862721 A GB862721 A GB 862721A
Authority
GB
United Kingdom
Prior art keywords
salts
capsules
tablets
carbon atoms
alkyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20835/59D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB862721A publication Critical patent/GB862721A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula: <FORM:0862721/IV (b)/1> (wherein R1 and R2 are alkyl groups each containing at most 4 carbon atoms) and non-toxic acid-addition salts thereof. They may be prepared by reacting methylsalicylate with the appropriate dialkylethylene diamine. Examples are given and salts with hydrohalic acids and sulphuric acid are referred to.ALSO:Pharmaceutical compositions comprise a compound of the formula <FORM:0862721/VI/1> (wherein R1 and R2 are alkyl groups each containing at most 4 carbon atoms) or a non-toxic acid-addition salt thereof in admixture with suitable fillers, carriers, extenders and/or excipients suitable for oral or parenteral administration. They may take the form of tablets, powders, capsules or suspensions and a suitable dosage unit contains about 25 to 300 milligrams of the active ingredient. In examples N-(2-diethylaminoethyl)-salicylamide hydrochloride is made up into tablets and capsules. Salts with hydrobromic and sulphuric acids are also referred to.
GB20835/59D 1958-06-23 1959-06-17 Dialkylaminoethyl derivatives of salicylamides Expired GB862721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US862721XA 1958-06-23 1958-06-23

Publications (1)

Publication Number Publication Date
GB862721A true GB862721A (en) 1961-03-15

Family

ID=22197448

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20835/59D Expired GB862721A (en) 1958-06-23 1959-06-17 Dialkylaminoethyl derivatives of salicylamides

Country Status (1)

Country Link
GB (1) GB862721A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272861A (en) * 1961-10-11 1966-09-13 Continental Oil Co Polyalkylene polyamine derivatives of hydroxybenzoic acid
US4140769A (en) 1976-12-23 1979-02-20 Miles Laboratories, Inc. 3-Substituted salicylamides
US4256664A (en) * 1973-03-12 1981-03-17 Colgate-Palmolive Company Substantive sunscreen agents
EP0353753A1 (en) * 1988-08-03 1990-02-07 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
US5218000A (en) * 1988-08-30 1993-06-08 National Research Development Corporation Therapeutic polyamine-amides
EP1372615A1 (en) * 2001-03-01 2004-01-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2007008963A1 (en) * 2005-07-13 2007-01-18 Jenrin Discovery Mao-b inhibitors useful for treating obesity

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272861A (en) * 1961-10-11 1966-09-13 Continental Oil Co Polyalkylene polyamine derivatives of hydroxybenzoic acid
US4256664A (en) * 1973-03-12 1981-03-17 Colgate-Palmolive Company Substantive sunscreen agents
US4140769A (en) 1976-12-23 1979-02-20 Miles Laboratories, Inc. 3-Substituted salicylamides
EP0353753A1 (en) * 1988-08-03 1990-02-07 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
US4990511A (en) * 1988-08-03 1991-02-05 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
US5218000A (en) * 1988-08-30 1993-06-08 National Research Development Corporation Therapeutic polyamine-amides
EP1372615A1 (en) * 2001-03-01 2004-01-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1372615A4 (en) * 2001-03-01 2007-09-12 Emisphere Tech Inc Compounds and compositions for delivering active agents
US7700775B2 (en) 2001-03-01 2010-04-20 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP2308479A3 (en) * 2001-03-01 2012-10-24 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
WO2007008963A1 (en) * 2005-07-13 2007-01-18 Jenrin Discovery Mao-b inhibitors useful for treating obesity
US8138209B2 (en) 2005-07-13 2012-03-20 Jenrin Discovery, Inc. Substituted picolinamides as MAO-B inhibitors useful for treating obesity

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