GB720477A - Improvements in or relating to anti-virus agents, and the preparation thereof - Google Patents
Improvements in or relating to anti-virus agents, and the preparation thereofInfo
- Publication number
- GB720477A GB720477A GB25818/51A GB2581851A GB720477A GB 720477 A GB720477 A GB 720477A GB 25818/51 A GB25818/51 A GB 25818/51A GB 2581851 A GB2581851 A GB 2581851A GB 720477 A GB720477 A GB 720477A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- agent
- antivirus
- oxytetracycline
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An antivirus agent is obtained by maintaining a solution of oxytetracycline under mildly alkaline conditions until substantial antivirus activity (test micro-organism influenza virus) is imparted to the solution. The solvent may be water, a water-miscible organic solvent, e.g. alcohol or a mixture thereof. A pH of 10 to 12 and a temperature of 20 DEG to 100 DEG C. is preferred. The higher the temperature, the shorter the digestion time. Thus at 20 DEG to 35 DEG C. the time is 2 to 10 days; at 90 DEG to 100 DEG C. the time is 1/2 to 3 hours. The lower temperature produces the most active product. The agent may be isolated from the solution by (a) freezy-drying or (b) acidifying to pH 2 to 4 and filtering off the separated solid. The original solution may be rendered alkaline by an organic or inorganic base, the alkali metal hydroxides being preferred. Any strong acid may be used in step (b); preferred are phosphoric, sulphuric or hydrochloric. The antivirus agent is active against the influenza A virus; has low solubility in dilute, aqueous acid; the acid form is soluble in acetone, methanol, butanol and pyridine, but insoluble in ether, chloroform, dioxane and acetonitrile; its activity against Klebsiella pneumoniae is preferably less than 10 per cent of that of oxytetracycline. The agent may be used therapeutically with other antibiotics (see Group VI).ALSO:A therapeutic preparation comprises a solution of an antivirus agent obtained by maintaining oxytetracycline under mildly alkaline conditions until substantial activity against the influenza A virus is obtained (see Group IV (b)]. Optional additions are penicillin, streptomycin, "Viomycin" (R.T.M.) or oxytetracyline.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US720477XA | 1951-05-11 | 1951-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB720477A true GB720477A (en) | 1954-12-22 |
Family
ID=22105235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB25818/51A Expired GB720477A (en) | 1951-05-11 | 1951-11-05 | Improvements in or relating to anti-virus agents, and the preparation thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB720477A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3105008A (en) * | 1958-03-20 | 1963-09-24 | Bristol Myers Co | Tetracycline formulations |
-
1951
- 1951-11-05 GB GB25818/51A patent/GB720477A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3105008A (en) * | 1958-03-20 | 1963-09-24 | Bristol Myers Co | Tetracycline formulations |
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