GB720477A - Improvements in or relating to anti-virus agents, and the preparation thereof - Google Patents

Improvements in or relating to anti-virus agents, and the preparation thereof

Info

Publication number
GB720477A
GB720477A GB25818/51A GB2581851A GB720477A GB 720477 A GB720477 A GB 720477A GB 25818/51 A GB25818/51 A GB 25818/51A GB 2581851 A GB2581851 A GB 2581851A GB 720477 A GB720477 A GB 720477A
Authority
GB
United Kingdom
Prior art keywords
solution
agent
antivirus
oxytetracycline
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25818/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB720477A publication Critical patent/GB720477A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

An antivirus agent is obtained by maintaining a solution of oxytetracycline under mildly alkaline conditions until substantial antivirus activity (test micro-organism influenza virus) is imparted to the solution. The solvent may be water, a water-miscible organic solvent, e.g. alcohol or a mixture thereof. A pH of 10 to 12 and a temperature of 20 DEG to 100 DEG C. is preferred. The higher the temperature, the shorter the digestion time. Thus at 20 DEG to 35 DEG C. the time is 2 to 10 days; at 90 DEG to 100 DEG C. the time is 1/2 to 3 hours. The lower temperature produces the most active product. The agent may be isolated from the solution by (a) freezy-drying or (b) acidifying to pH 2 to 4 and filtering off the separated solid. The original solution may be rendered alkaline by an organic or inorganic base, the alkali metal hydroxides being preferred. Any strong acid may be used in step (b); preferred are phosphoric, sulphuric or hydrochloric. The antivirus agent is active against the influenza A virus; has low solubility in dilute, aqueous acid; the acid form is soluble in acetone, methanol, butanol and pyridine, but insoluble in ether, chloroform, dioxane and acetonitrile; its activity against Klebsiella pneumoniae is preferably less than 10 per cent of that of oxytetracycline. The agent may be used therapeutically with other antibiotics (see Group VI).ALSO:A therapeutic preparation comprises a solution of an antivirus agent obtained by maintaining oxytetracycline under mildly alkaline conditions until substantial activity against the influenza A virus is obtained (see Group IV (b)]. Optional additions are penicillin, streptomycin, "Viomycin" (R.T.M.) or oxytetracyline.
GB25818/51A 1951-05-11 1951-11-05 Improvements in or relating to anti-virus agents, and the preparation thereof Expired GB720477A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US720477XA 1951-05-11 1951-05-11

Publications (1)

Publication Number Publication Date
GB720477A true GB720477A (en) 1954-12-22

Family

ID=22105235

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25818/51A Expired GB720477A (en) 1951-05-11 1951-11-05 Improvements in or relating to anti-virus agents, and the preparation thereof

Country Status (1)

Country Link
GB (1) GB720477A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105008A (en) * 1958-03-20 1963-09-24 Bristol Myers Co Tetracycline formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105008A (en) * 1958-03-20 1963-09-24 Bristol Myers Co Tetracycline formulations

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