GB669070A - Improvements in or relating to compounds of the dimethyl xanthine series and production thereof - Google Patents
Improvements in or relating to compounds of the dimethyl xanthine series and production thereofInfo
- Publication number
- GB669070A GB669070A GB15809/49A GB1580949A GB669070A GB 669070 A GB669070 A GB 669070A GB 15809/49 A GB15809/49 A GB 15809/49A GB 1580949 A GB1580949 A GB 1580949A GB 669070 A GB669070 A GB 669070A
- Authority
- GB
- United Kingdom
- Prior art keywords
- theophylline
- reacted
- converted
- product
- theobromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B64—AIRCRAFT; AVIATION; COSMONAUTICS
- B64C—AEROPLANES; HELICOPTERS
- B64C3/00—Wings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Aviation & Aerospace Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Theophylline is reacted in alkaline medium with a dialkylamino-alkyl halide, the latter alkyl group containing 2-4 carbon atoms; alternatively, theophylline is treated with a glycol monochlorhydrin to form the hydroxyalkyl derivative, converted into the chloroalkyl compound and finally reacted with a dialkylamine. The products are the 7-dialkylaminoalkyl derivatives and may be converted into quaternary salts and acid addition salts. In the examples: (1) theophylline is converted directly into 7-(b -diethylaminoethyl)-theophylline; (2) the product of (1) forms a hydrochloride, hydriodide, camphosulphonate and picrate by direct addition or double decomposition; (3) the product of (1) is reacted with methyl iodide; (4) as in (1)-(3) using b -dimethylaminoethyl chloride; (5) theophylline is reacted with bromocholine bromide to give a quaternary salt directly; (6) theophylline is converted successively into the 7-b -hydroxyethyl, 7-b -chloroethyl and 7-b -diethylaminoethyl derivatives. The Specification as open to inspection under Sect. 91 mentions similar reactions with theobromine, where substitution occurs in the 1-position. The substituent in the product from theobromine or theophylline may be any organic radical containing a primary, secondary, tertiary or quaternary amino group. A further product specified is 1-(2-diethylaminoethyl)-theobromine. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR669070X | 1948-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB669070A true GB669070A (en) | 1952-03-26 |
Family
ID=9015499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15809/49A Expired GB669070A (en) | 1948-06-28 | 1949-06-14 | Improvements in or relating to compounds of the dimethyl xanthine series and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB669070A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE962610C (en) * | 1953-07-08 | 1957-04-25 | Donau Pharmazie G M B H | Process for the preparation of 1- (ª ‰ -Diaethylaminoaethyl) -theobromine-bromaethylate |
| DE1011424B (en) * | 1954-04-17 | 1957-07-04 | Chemiewerk Homburg Ag | Process for the preparation of basic substituted 7-alkyl-xanthine derivatives or their salts |
| DE1018869B (en) * | 1954-12-14 | 1957-11-07 | Boehringer Sohn Ingelheim | Process for the preparation of aminoalkyl purine derivatives |
| US2879271A (en) * | 1953-07-23 | 1959-03-24 | Knoll Ag | Basic derivatives of mono- and dimethyl xanthines, and a process of making same |
| DE1100640B (en) * | 1956-09-25 | 1961-03-02 | Chemiewerk Homburg | Process for the preparation of basic substituted alkylxanthine derivatives |
-
1949
- 1949-06-14 GB GB15809/49A patent/GB669070A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE962610C (en) * | 1953-07-08 | 1957-04-25 | Donau Pharmazie G M B H | Process for the preparation of 1- (ª ‰ -Diaethylaminoaethyl) -theobromine-bromaethylate |
| US2879271A (en) * | 1953-07-23 | 1959-03-24 | Knoll Ag | Basic derivatives of mono- and dimethyl xanthines, and a process of making same |
| DE1011424B (en) * | 1954-04-17 | 1957-07-04 | Chemiewerk Homburg Ag | Process for the preparation of basic substituted 7-alkyl-xanthine derivatives or their salts |
| DE1018869B (en) * | 1954-12-14 | 1957-11-07 | Boehringer Sohn Ingelheim | Process for the preparation of aminoalkyl purine derivatives |
| DE1100640B (en) * | 1956-09-25 | 1961-03-02 | Chemiewerk Homburg | Process for the preparation of basic substituted alkylxanthine derivatives |
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