GB2571937B - Stable liquid suspension composition of fludrocortisone - Google Patents

Stable liquid suspension composition of fludrocortisone Download PDF

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Publication number
GB2571937B
GB2571937B GB1803893.5A GB201803893A GB2571937B GB 2571937 B GB2571937 B GB 2571937B GB 201803893 A GB201803893 A GB 201803893A GB 2571937 B GB2571937 B GB 2571937B
Authority
GB
United Kingdom
Prior art keywords
fludrocortisone
liquid suspension
stable liquid
suspension composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1803893.5A
Other versions
GB201803893D0 (en
GB2571937A (en
Inventor
Maganbhai Patel Sanjaykumar
Patel Kamlesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syri Ltd
Original Assignee
Syri Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syri Ltd filed Critical Syri Ltd
Priority to GB1803893.5A priority Critical patent/GB2571937B/en
Publication of GB201803893D0 publication Critical patent/GB201803893D0/en
Priority to EP19713218.6A priority patent/EP3764989A1/en
Priority to PCT/IB2019/051696 priority patent/WO2019175703A1/en
Publication of GB2571937A publication Critical patent/GB2571937A/en
Application granted granted Critical
Publication of GB2571937B publication Critical patent/GB2571937B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB1803893.5A 2018-03-12 2018-03-12 Stable liquid suspension composition of fludrocortisone Expired - Fee Related GB2571937B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB1803893.5A GB2571937B (en) 2018-03-12 2018-03-12 Stable liquid suspension composition of fludrocortisone
EP19713218.6A EP3764989A1 (en) 2018-03-12 2019-03-03 Stable liquid suspension composition of fludrocortisone
PCT/IB2019/051696 WO2019175703A1 (en) 2018-03-12 2019-03-03 Stable liquid suspension composition of fludrocortisone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1803893.5A GB2571937B (en) 2018-03-12 2018-03-12 Stable liquid suspension composition of fludrocortisone

Publications (3)

Publication Number Publication Date
GB201803893D0 GB201803893D0 (en) 2018-04-25
GB2571937A GB2571937A (en) 2019-09-18
GB2571937B true GB2571937B (en) 2021-07-14

Family

ID=61972944

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1803893.5A Expired - Fee Related GB2571937B (en) 2018-03-12 2018-03-12 Stable liquid suspension composition of fludrocortisone

Country Status (3)

Country Link
EP (1) EP3764989A1 (en)
GB (1) GB2571937B (en)
WO (1) WO2019175703A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE063183T2 (en) * 2020-02-25 2024-01-28 Labomed Pharmaceutical Company S A Oral solutions comprising fludrocortisone acetate
CN111759814A (en) * 2020-07-20 2020-10-13 华益药业科技(安徽)有限公司 Fludrocortisone acetate tablet for resisting inflammation and processing technology
CN111803457A (en) * 2020-07-20 2020-10-23 华益药业科技(安徽)有限公司 Fludrocortisone acetate tablet and processing technology thereof
CN111759812A (en) * 2020-07-20 2020-10-13 华益药业科技(安徽)有限公司 Fludrocortisone acetate tablet for inhibiting proliferation of connective hoof tissue and processing technology thereof
CN113350297B (en) * 2021-06-11 2022-11-04 河南金大众生物工程有限公司 Tilmicosin dry suspension and preparation method thereof
JP2024529509A (en) * 2021-07-30 2024-08-06 エピジェニクス セラピューティクス インコーポレーテッド Clemizole preparations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112604A (en) * 1989-09-01 1992-05-12 Riker Laboratories, Inc. Oral suspension formulation
WO2003082243A1 (en) * 2002-04-03 2003-10-09 Venus Danilo R Oral suspension formulation
US20060093631A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004039328A2 (en) * 2002-10-29 2004-05-13 Oregon Health & Science University Fludrocortisone treatment for hearing loss
JP5334588B2 (en) * 2005-11-28 2013-11-06 マリナス ファーマシューティカルズ Ganaxolone preparation, method for producing the same, and use thereof
JP2010510988A (en) * 2006-11-28 2010-04-08 マリナス ファーマシューティカルズ Nanoparticle formulation, method for producing the same and use thereof
WO2010068775A2 (en) * 2008-12-11 2010-06-17 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
US8377946B1 (en) * 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
AU2015218642A1 (en) * 2014-02-24 2016-10-06 Michael Goldberg Compositions of pentosan polysulfate salts for oral administration and methods of use
WO2017218894A1 (en) * 2016-06-16 2017-12-21 Cutispharma, Inc. Composition and method for proton pump inhibitor suspension

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112604A (en) * 1989-09-01 1992-05-12 Riker Laboratories, Inc. Oral suspension formulation
WO2003082243A1 (en) * 2002-04-03 2003-10-09 Venus Danilo R Oral suspension formulation
US20060093631A1 (en) * 2004-10-29 2006-05-04 Buehler Gail K Dye-free pharmaceutical suspensions and related methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
European Journal of Pharmaceutics and Biopharmaceutics, vol. 55, 2003, pages 209-213 *

Also Published As

Publication number Publication date
GB201803893D0 (en) 2018-04-25
WO2019175703A1 (en) 2019-09-19
GB2571937A (en) 2019-09-18
EP3764989A1 (en) 2021-01-20

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20220312