GB2244705B - Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof - Google Patents

Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof

Info

Publication number
GB2244705B
GB2244705B GB9105304A GB9105304A GB2244705B GB 2244705 B GB2244705 B GB 2244705B GB 9105304 A GB9105304 A GB 9105304A GB 9105304 A GB9105304 A GB 9105304A GB 2244705 B GB2244705 B GB 2244705B
Authority
GB
United Kingdom
Prior art keywords
intermediates
preparation
tetrazole compounds
antihypercholesterolemic
antihypercholesterolemic tetrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9105304A
Other versions
GB9105304D0 (en
GB2244705A (en
Inventor
William T Han
John J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/156,865 external-priority patent/US4824959A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB9105304D0 publication Critical patent/GB9105304D0/en
Publication of GB2244705A publication Critical patent/GB2244705A/en
Application granted granted Critical
Publication of GB2244705B publication Critical patent/GB2244705B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB9105304A 1988-02-18 1991-03-13 Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof Expired - Lifetime GB2244705B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/156,865 US4824959A (en) 1988-02-18 1988-02-18 Intermediates for antihypercholesterolemic tetrazole compounds
GB8903604A GB2216121B (en) 1988-02-18 1989-02-16 6-alkenyl-1,3-dioxane-4-acetic acid derivatives

Publications (3)

Publication Number Publication Date
GB9105304D0 GB9105304D0 (en) 1991-04-24
GB2244705A GB2244705A (en) 1991-12-11
GB2244705B true GB2244705B (en) 1992-07-15

Family

ID=26294971

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9105305A Expired - Lifetime GB2244706B (en) 1988-02-18 1991-03-13 Preparation of antihypercholesterolemic tetrazole intermediates
GB9105304A Expired - Lifetime GB2244705B (en) 1988-02-18 1991-03-13 Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB9105305A Expired - Lifetime GB2244706B (en) 1988-02-18 1991-03-13 Preparation of antihypercholesterolemic tetrazole intermediates

Country Status (2)

Country Link
CY (2) CY1876A (en)
GB (2) GB2244706B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
EP1417180B1 (en) 2001-07-13 2006-12-27 AstraZeneca UK Limited Preparation of aminopyrimidine compounds
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006584A1 (en) * 1987-02-25 1988-09-07 Bristol-Myers Company Antihypercholesterolemic tetrazole compounds
GB2216121A (en) * 1988-02-18 1989-10-04 Bristol Myers Co Preparation of antihypercholesterolmic teraazole compounds and intermediates thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006584A1 (en) * 1987-02-25 1988-09-07 Bristol-Myers Company Antihypercholesterolemic tetrazole compounds
GB2216121A (en) * 1988-02-18 1989-10-04 Bristol Myers Co Preparation of antihypercholesterolmic teraazole compounds and intermediates thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tetrahedron Letts. 27(43) 5201-2 (1986) *

Also Published As

Publication number Publication date
GB2244706A (en) 1991-12-11
GB2244706B (en) 1992-07-15
CY1875A (en) 1996-04-05
GB9105304D0 (en) 1991-04-24
CY1876A (en) 1996-04-05
GB2244705A (en) 1991-12-11
GB9105305D0 (en) 1991-04-24

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20090215