GB2167414B - Flavolignan derivatives and pharmaceutical compositions containing them - Google Patents

Flavolignan derivatives and pharmaceutical compositions containing them

Info

Publication number: GB2167414B
Authority: GB; United Kingdom
Prior art keywords: flavolignan; derivatives; pharmaceutical compositions; compositions containing; pharmaceutical
Prior art date: 1984-11-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB08528226A

Other versions

GB2167414A (en

GB8528226D0 (en

Inventor

Reinhard Braatz

Klaus Gorler

Gunter Halbach

Hartwig Soicke

Karlheinz Schmidt

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Madaus Holding GmbH

Original Assignee

Dr Madaus GmbH and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-22

Filing date

1985-11-15

Publication date

1989-01-11

1985-11-15 Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co

1985-12-18 Publication of GB8528226D0 publication Critical patent/GB8528226D0/en

1986-05-29 Publication of GB2167414A publication Critical patent/GB2167414A/en

1989-01-11 Application granted granted Critical

1989-01-11 Publication of GB2167414B publication Critical patent/GB2167414B/en

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Gastroenterology & Hepatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Silicon Compounds (AREA)

GB08528226A 1984-11-22 1985-11-15 Flavolignan derivatives and pharmaceutical compositions containing them Expired GB2167414B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843442639 DE3442639A1 (en)	1984-11-22	1984-11-22	FLAVOLIGNANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (3)

Publication Number	Publication Date
GB8528226D0 GB8528226D0 (en)	1985-12-18
GB2167414A GB2167414A (en)	1986-05-29
GB2167414B true GB2167414B (en)	1989-01-11

Family

ID=6250903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB08528226A Expired GB2167414B (en)	1984-11-22	1985-11-15	Flavolignan derivatives and pharmaceutical compositions containing them

Country Status (29)

Country	Link
JP (1)	JPS61143377A (en)
KR (1)	KR870001020B1 (en)
AR (1)	AR240931A1 (en)
AT (1)	AT393268B (en)
BE (1)	BE903693A (en)
CA (1)	CA1337124C (en)
CH (1)	CH659473A5 (en)
CS (1)	CS273610B2 (en)
DD (1)	DD259191A1 (en)
DE (1)	DE3442639A1 (en)
DK (1)	DK164865C (en)
EG (1)	EG19424A (en)
ES (1)	ES8609311A1 (en)
FI (1)	FI84064C (en)
FR (1)	FR2573427B1 (en)
GB (1)	GB2167414B (en)
HU (1)	HU195503B (en)
IE (1)	IE58791B1 (en)
IT (1)	IT1190426B (en)
LU (1)	LU86163A1 (en)
MX (1)	MX168415B (en)
NL (1)	NL192387C (en)
NO (1)	NO160205C (en)
PL (1)	PL146890B1 (en)
PT (1)	PT81532B (en)
SE (1)	SE465676B (en)
SU (1)	SU1436875A3 (en)
YU (1)	YU43689B (en)
ZA (1)	ZA858951B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8716918D0 (en) *	1987-07-17	1987-08-26	Inverni Della Beffa Spa	Soluble derivatives of silybin
US5262439A (en) *	1992-04-30	1993-11-16	The Regents Of The University Of California	Soluble analogs of probucol
NZ560633A (en) *	2005-03-11	2011-08-26	Neuprotect Pty Ltd	Flavonoid compounds and uses thereof
RU2482844C2 (en) *	2007-11-15	2013-05-27	Мадаус Гмбх	Silibilin component for treating hepatitis
ES2374117T3 (en)	2007-11-15	2012-02-13	Madaus Gmbh	SILIBININE COMPONENT FOR THE TREATMENT OF HEPATITIS.
CA2761656C (en) *	2009-05-14	2017-02-07	Lucio Claudio Rovati	Amorphous silibinin for the treatment of viral hepatitis
WO2014008341A2 (en)	2012-07-05	2014-01-09	Nutramax Laboratories, Inc.	Compositions comprising sulforaphane or a sulforaphane precursor and magnesium
CN103172622B (en) *	2013-02-22	2015-11-04	西安安健药业有限公司	The active isomer of silybin bis-bias succinate
CN103113359B (en) *	2013-02-22	2016-01-06	西安安健药业有限公司	Silybin bis-bias succinate and pharmaceutical salts thereof
CN103193768B (en) *	2013-02-22	2016-03-30	西安安健药业有限公司	The silybin bis-bias succinate isomer for the treatment of hepatopathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963318A1 (en) *	1969-12-17	1971-06-24	Schwabe Willmar Gmbh & Co	Silybin esters with hepotoprotactant acti- - vity

1984
- 1984-11-22 DE DE19843442639 patent/DE3442639A1/en active Granted
1985
- 1985-11-11 IE IE280885A patent/IE58791B1/en not_active IP Right Cessation
- 1985-11-13 LU LU86163A patent/LU86163A1/en unknown
- 1985-11-14 AR AR302267A patent/AR240931A1/en active
- 1985-11-14 YU YU1786/85A patent/YU43689B/en unknown
- 1985-11-15 GB GB08528226A patent/GB2167414B/en not_active Expired
- 1985-11-18 FI FI854535A patent/FI84064C/en not_active IP Right Cessation
- 1985-11-18 NL NL8503171A patent/NL192387C/en not_active IP Right Cessation
- 1985-11-19 CH CH4935/85A patent/CH659473A5/en not_active IP Right Cessation
- 1985-11-19 AT AT3371/85A patent/AT393268B/en not_active IP Right Cessation
- 1985-11-20 SE SE8505487A patent/SE465676B/en not_active IP Right Cessation
- 1985-11-20 DD DD85283042A patent/DD259191A1/en not_active IP Right Cessation
- 1985-11-20 CS CS837885A patent/CS273610B2/en unknown
- 1985-11-20 CA CA000495804A patent/CA1337124C/en not_active Expired - Fee Related
- 1985-11-21 NO NO854655A patent/NO160205C/en not_active IP Right Cessation
- 1985-11-21 ES ES549116A patent/ES8609311A1/en not_active Expired
- 1985-11-21 HU HU854448A patent/HU195503B/en not_active IP Right Cessation
- 1985-11-21 ZA ZA858951A patent/ZA858951B/en unknown
- 1985-11-21 IT IT22932/85A patent/IT1190426B/en active
- 1985-11-21 EG EG74085A patent/EG19424A/en active
- 1985-11-21 DK DK537785A patent/DK164865C/en not_active IP Right Cessation
- 1985-11-21 PT PT81532A patent/PT81532B/en not_active IP Right Cessation
- 1985-11-21 SU SU853985401A patent/SU1436875A3/en active
- 1985-11-21 PL PL1985256374A patent/PL146890B1/en unknown
- 1985-11-22 JP JP60261629A patent/JPS61143377A/en active Granted
- 1985-11-22 FR FR858517321A patent/FR2573427B1/en not_active Expired
- 1985-11-22 KR KR1019850008733A patent/KR870001020B1/en not_active IP Right Cessation
- 1985-11-22 MX MX009022A patent/MX168415B/en unknown
- 1985-11-22 BE BE2/60850A patent/BE903693A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CS273610B2 (en)	1991-03-12
SE8505487L (en)	1986-05-23
YU178685A (en)	1988-02-29
SU1436875A3 (en)	1988-11-07
NO160205C (en)	1989-03-22
BE903693A (en)	1986-05-22
GB2167414A (en)	1986-05-29
FI84064B (en)	1991-06-28
CH659473A5 (en)	1987-01-30
NL192387C (en)	1997-07-04
SE8505487D0 (en)	1985-11-20
DD259191A1 (en)	1988-08-17
EG19424A (en)	1995-02-28
AT393268B (en)	1991-09-25
HUT40114A (en)	1986-11-28
LU86163A1 (en)	1986-03-24
PT81532B (en)	1987-11-11
AR240931A2 (en)	1991-03-27
CS837885A2 (en)	1990-08-14
NO160205B (en)	1988-12-12
PL146890B1 (en)	1989-03-31
SE465676B (en)	1991-10-14
IT8522932A0 (en)	1985-11-21
DE3442639A1 (en)	1986-05-22
DK164865C (en)	1993-01-18
GB8528226D0 (en)	1985-12-18
ES549116A0 (en)	1986-09-01
KR870001020B1 (en)	1987-05-23
ES8609311A1 (en)	1986-09-01
CA1337124C (en)	1995-09-26
DK537785D0 (en)	1985-11-21
KR860004056A (en)	1986-06-16
PT81532A (en)	1985-12-01
IE852808L (en)	1986-05-22
ATA337185A (en)	1991-02-15
IE58791B1 (en)	1993-11-17
AR240931A1 (en)	1991-03-27
FR2573427A1 (en)	1986-05-23
NL192387B (en)	1997-03-03
DE3442639C2 (en)	1989-08-10
JPH0432073B2 (en)	1992-05-28
FR2573427B1 (en)	1989-03-10
ZA858951B (en)	1986-08-27
PL256374A1 (en)	1986-12-02
YU43689B (en)	1989-10-31
HU195503B (en)	1988-05-30
JPS61143377A (en)	1986-07-01
NL8503171A (en)	1986-06-16
MX168415B (en)	1993-05-24
DK537785A (en)	1986-05-23
DK164865B (en)	1992-08-31
FI854535A0 (en)	1985-11-18
IT1190426B (en)	1988-02-16
NO854655L (en)	1986-05-23
FI854535A (en)	1986-05-23
FI84064C (en)	1991-10-10

Legal Events

Date	Code	Title	Description
1990-04-25	732	Registration of transactions, instruments or events in the register (sect. 32/1977)

Publication	Publication Date	Title
IL74758A0 (en)	1985-06-30	Acyltripeptides and pharmaceutical compositions containing them
NZ211145A (en)	1988-10-28	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
IL72028A0 (en)	1984-10-31	Aminomethyl-oxooxazolidinylbenzene derivatives and pharmaceutical compositions containing them
NZ220345A (en)	1990-10-26	Imidazoquinolinylether derivatives and pharmaceutical compositions containing them
NZ212005A (en)	1989-07-27	Pyrrolobenzimidazoles and pharmaceutical compositions
IL75326A0 (en)	1985-09-29	Quinolone derivatives and pharmaceutical compositions containing them
NZ211031A (en)	1989-08-29	6-substituted-4-dialkylaminotetrahindole derivatives and pharmaceutical compositions
NZ212099A (en)	1989-08-29	Substituted arylhydroxamates and pharmaceutical compositions
IL76405A (en)	1990-03-19	1,3-diacyl-2-oxindole derivatives and pharmaceutical compositions containing them
IL74865A0 (en)	1985-07-31	9a-aza-9a-homoerythromycin derivatives and pharmaceutical compositions containing them
IL79376A0 (en)	1986-10-31	Substituted di-t-butylphenols and pharmaceutical compositions containing them
IL76188A (en)	1990-11-29	3-aralkylidene-hydroxy-flavanone derivatives and pharmaceutical compositions containing them
IL82205A (en)	1991-05-12	Substituted alkane-sulfonamidophenyl derivatives and pharmaceutical compositions containing them
NZ214175A (en)	1989-04-26	Cholecalciferol derivatives and pharmaceutical compositions
NZ210818A (en)	1989-02-24	8-alpha-acylaminoergoline derivatives and pharmaceutical compositions
IL86711A0 (en)	1988-11-30	5-pyrimidinecarboxamide derivatives and pharmaceutical compositions containing them
IL75740A0 (en)	1985-11-29	Benzothiophene derivatives and pharmaceutical compositions containing them
NZ225466A (en)	1990-02-26	1-aminoalkyl-1h-indole derivatives and pharmaceutical compositions containing certain derivatives thereof
GB2167414B (en)	1989-01-11	Flavolignan derivatives and pharmaceutical compositions containing them
DE3473444D1 (en)	1988-09-22	Acylindole derivatives and pharmaceutical compositions containing them
IL79003A0 (en)	1986-09-30	Tetrahydroimidazoquinazolinones and pharmaceutical compositions containing them
IL74071A0 (en)	1985-04-30	Dihydropyridine derivatives and pharmaceutical compositions containing them
NZ213581A (en)	1989-04-26	Carboxyalkyldipeptides and pharmaceutical compositions
IL73224A (en)	1988-09-30	2-dioxacycloalkylthiopenem derivatives and pharmaceutical compositions containing them
IL74667A (en)	1988-12-30	Spiro-oxazolidones,-thiazolidones and-imidazolidones and pharmaceutical compositions containing them