GB2025930B - Process for the production of pleuromutilin derivatives - Google Patents

Process for the production of pleuromutilin derivatives

Info

Publication number
GB2025930B
GB2025930B GB7826203A GB7826203A GB2025930B GB 2025930 B GB2025930 B GB 2025930B GB 7826203 A GB7826203 A GB 7826203A GB 7826203 A GB7826203 A GB 7826203A GB 2025930 B GB2025930 B GB 2025930B
Authority
GB
United Kingdom
Prior art keywords
production
pleuromutilin derivatives
pleuromutilin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7826203A
Other versions
GB2025930A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Priority to GB7826203A priority Critical patent/GB2025930B/en
Publication of GB2025930A publication Critical patent/GB2025930A/en
Application granted granted Critical
Publication of GB2025930B publication Critical patent/GB2025930B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB7826203A 1978-06-01 1978-06-01 Process for the production of pleuromutilin derivatives Expired GB2025930B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7826203A GB2025930B (en) 1978-06-01 1978-06-01 Process for the production of pleuromutilin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7826203A GB2025930B (en) 1978-06-01 1978-06-01 Process for the production of pleuromutilin derivatives

Publications (2)

Publication Number Publication Date
GB2025930A GB2025930A (en) 1980-01-30
GB2025930B true GB2025930B (en) 1983-02-09

Family

ID=10497830

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7826203A Expired GB2025930B (en) 1978-06-01 1978-06-01 Process for the production of pleuromutilin derivatives

Country Status (1)

Country Link
GB (1) GB2025930B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (en) * 1997-10-29 2000-12-29 Smithkline Beecham Plc PLEUROMUTILINE DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS
GB0218578D0 (en) 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
GB0504314D0 (en) 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
CN103450060A (en) * 2012-05-29 2013-12-18 大英九合生物化工股份有限公司 Synthesis method of tiamulin
CN103113271B (en) * 2013-03-05 2015-04-01 青岛科技大学 Preparation method of tiamulin alkali
CN104262210B (en) * 2014-08-29 2016-06-15 宁夏泰瑞制药股份有限公司 A kind of method extracting paratoluenesulfonic acid sodium salt from Tiamulin synthetic wastewater
CN106543054B (en) * 2016-09-30 2019-09-03 华南农业大学 A kind of pleuromutilin derivative and its preparation method and application with 2- amino second mercapto alcohol side chain
CN107759502B (en) * 2017-10-11 2019-09-10 中国农业科学院兰州畜牧与兽药研究所 A kind of preparation method of Tiamulin

Also Published As

Publication number Publication date
GB2025930A (en) 1980-01-30

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19980531