GB1557271A - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- GB1557271A GB1557271A GB39798/76A GB3979876A GB1557271A GB 1557271 A GB1557271 A GB 1557271A GB 39798/76 A GB39798/76 A GB 39798/76A GB 3979876 A GB3979876 A GB 3979876A GB 1557271 A GB1557271 A GB 1557271A
- Authority
- GB
- United Kingdom
- Prior art keywords
- neothramycin
- methylneothramycin
- fractionated
- benzodiazepine derivatives
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Neothramycin A and neothramycin B are obtained by culturing a neothramycin-producing strain of the genus Streptomyces under aerobic conditions in a medium containing assimilable carbon and sources of nitrogen. The resulting mixture can be fractionated. Treatment of each of the two neothramycins with methanol yields a mixture of methylneothramycin A and methylneothramycin B, which can again be fractionated. All the four compounds are valuable pharmaceuticals for use against leukaemia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50123256A JPS5247992A (en) | 1975-10-15 | 1975-10-15 | Method of manufacturing new antibiotics, neothramycin a and b |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1557271A true GB1557271A (en) | 1979-12-05 |
Family
ID=14856057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB39798/76A Expired GB1557271A (en) | 1975-10-15 | 1976-09-24 | Benzodiazepine derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5247992A (en) |
AT (2) | AT349630B (en) |
AU (1) | AU505643B2 (en) |
BE (1) | BE847372A (en) |
CA (1) | CA1056748A (en) |
CH (1) | CH629253A5 (en) |
DE (1) | DE2645528C3 (en) |
ES (1) | ES452443A1 (en) |
FR (1) | FR2351659A1 (en) |
GB (1) | GB1557271A (en) |
NL (1) | NL175198C (en) |
SE (1) | SE432443B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464467A (en) * | 1982-07-26 | 1984-08-07 | Bristol-Myers Company | Antitumor antibiotics produced by new streptomyces |
FR2586683B1 (en) * | 1985-08-29 | 1988-07-01 | Centre Nat Rech Scient | NOVEL NEOTHRAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
-
1975
- 1975-10-15 JP JP50123256A patent/JPS5247992A/en active Granted
-
1976
- 1976-05-27 CA CA253,467A patent/CA1056748A/en not_active Expired
- 1976-09-24 GB GB39798/76A patent/GB1557271A/en not_active Expired
- 1976-09-27 AU AU18116/76A patent/AU505643B2/en not_active Expired
- 1976-10-08 DE DE2645528A patent/DE2645528C3/en not_active Expired
- 1976-10-11 NL NLAANVRAGE7611211,A patent/NL175198C/en not_active IP Right Cessation
- 1976-10-12 SE SE7611320A patent/SE432443B/en not_active IP Right Cessation
- 1976-10-12 FR FR7630592A patent/FR2351659A1/en active Granted
- 1976-10-14 AT AT764076A patent/AT349630B/en not_active IP Right Cessation
- 1976-10-15 BE BE171582A patent/BE847372A/en not_active IP Right Cessation
- 1976-10-15 CH CH1310176A patent/CH629253A5/en not_active IP Right Cessation
- 1976-10-15 ES ES452443A patent/ES452443A1/en not_active Expired
-
1978
- 1978-07-20 AT AT527178A patent/AT358172B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE2645528B2 (en) | 1979-06-28 |
JPS5247992A (en) | 1977-04-16 |
FR2351659B1 (en) | 1979-07-06 |
CH629253A5 (en) | 1982-04-15 |
NL7611211A (en) | 1977-04-19 |
ATA764076A (en) | 1978-09-15 |
AU1811676A (en) | 1978-04-06 |
AT358172B (en) | 1980-08-25 |
DE2645528A1 (en) | 1977-04-21 |
CA1056748A (en) | 1979-06-19 |
ES452443A1 (en) | 1977-11-01 |
SE7611320L (en) | 1977-04-16 |
AU505643B2 (en) | 1979-11-29 |
FR2351659A1 (en) | 1977-12-16 |
AT349630B (en) | 1979-04-10 |
NL175198B (en) | 1984-05-01 |
NL175198C (en) | 1984-10-01 |
BE847372A (en) | 1977-01-31 |
DE2645528C3 (en) | 1980-02-28 |
ATA527178A (en) | 1980-01-15 |
JPS5444759B2 (en) | 1979-12-27 |
SE432443B (en) | 1984-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930924 |