GB1522537A - 2,4-diamino-5-benzylpyrimidines - Google Patents
2,4-diamino-5-benzylpyrimidinesInfo
- Publication number
- GB1522537A GB1522537A GB40800/76A GB4080076A GB1522537A GB 1522537 A GB1522537 A GB 1522537A GB 40800/76 A GB40800/76 A GB 40800/76A GB 4080076 A GB4080076 A GB 4080076A GB 1522537 A GB1522537 A GB 1522537A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- image
- benzylpyrimidines
- diamino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
2,4-Diamino-5-benzylpyrimidines of the formula (I) <IMAGE> in which R is an alkyl group with 1-4 carbon atoms or a halogen atom are prepared by reacting an appropriate beta -aminoacrylonitrile of the formula (V) <IMAGE> in which R' is an anilino group which is optionally substituted, or a morpholino group, with guanidine to give a compound of the formula (VI) <IMAGE> and converting the latter by elimination of the methoxymethyl radical into the compound of the formula (I). The compounds (I) can be obtained as acid addition salts and be used for chemotherapeutic purposes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2546667A DE2546667C3 (en) | 1975-10-17 | 1975-10-17 | 2,4-DiamuH »-5- (3-methoxy-4-hydroxy-5-halobenzyl) -pyrimidines, and medicinal products containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1522537A true GB1522537A (en) | 1978-08-23 |
Family
ID=5959437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40800/76A Expired GB1522537A (en) | 1975-10-17 | 1976-10-01 | 2,4-diamino-5-benzylpyrimidines |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5251376A (en) |
| AR (1) | AR210905A1 (en) |
| AT (1) | AT352735B (en) |
| AU (1) | AU1724576A (en) |
| BE (1) | BE846397A (en) |
| CA (1) | CA1055498A (en) |
| CH (1) | CH623313A5 (en) |
| DE (1) | DE2546667C3 (en) |
| ES (1) | ES451375A1 (en) |
| FR (1) | FR2327786A1 (en) |
| GB (1) | GB1522537A (en) |
| GR (1) | GR60352B (en) |
| HU (1) | HU174155B (en) |
| IL (1) | IL50430A0 (en) |
| MX (1) | MX4485E (en) |
| NL (1) | NL7609652A (en) |
| PT (1) | PT65482B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720771C3 (en) | 1977-05-09 | 1979-11-29 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | 2,4-Diamino-5- (33-dimethoxy-4thioalkyl-benzyD-pyrimidines, process for their preparation and pharmaceuticals containing these compounds |
| EP0006987A1 (en) * | 1978-05-24 | 1980-01-23 | The Wellcome Foundation Limited | 2,4-Diamino-5-benzylpyrimidines, especially for the treatment of microbial infections, pharmaceutical compositions containing these compounds and processes for preparing these compounds |
| HU188588B (en) * | 1982-08-13 | 1986-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives |
-
1975
- 1975-10-17 DE DE2546667A patent/DE2546667C3/en not_active Expired
-
1976
- 1976-07-28 CH CH962676A patent/CH623313A5/en not_active IP Right Cessation
- 1976-08-03 GR GR51404A patent/GR60352B/en unknown
- 1976-08-17 PT PT65482A patent/PT65482B/en unknown
- 1976-08-27 AU AU17245/76A patent/AU1724576A/en not_active Expired
- 1976-08-31 NL NL7609652A patent/NL7609652A/en not_active Application Discontinuation
- 1976-09-01 AT AT649276A patent/AT352735B/en not_active IP Right Cessation
- 1976-09-08 IL IL50430A patent/IL50430A0/en unknown
- 1976-09-09 ES ES451375A patent/ES451375A1/en not_active Expired
- 1976-09-16 FR FR7627872A patent/FR2327786A1/en active Granted
- 1976-09-21 BE BE170783A patent/BE846397A/en unknown
- 1976-09-22 AR AR264813A patent/AR210905A1/en active
- 1976-09-27 CA CA262,152A patent/CA1055498A/en not_active Expired
- 1976-10-01 GB GB40800/76A patent/GB1522537A/en not_active Expired
- 1976-10-01 MX MX764949U patent/MX4485E/en unknown
- 1976-10-01 HU HU76HE722A patent/HU174155B/en unknown
- 1976-10-01 JP JP51118916A patent/JPS5251376A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AT352735B (en) | 1979-10-10 |
| CH623313A5 (en) | 1981-05-29 |
| ES451375A1 (en) | 1981-10-16 |
| JPS5251376A (en) | 1977-04-25 |
| ATA649276A (en) | 1979-03-15 |
| DE2546667A1 (en) | 1977-04-28 |
| CA1055498A (en) | 1979-05-29 |
| PT65482B (en) | 1978-02-13 |
| GR60352B (en) | 1978-05-18 |
| IL50430A0 (en) | 1976-11-30 |
| PT65482A (en) | 1976-09-01 |
| HU174155B (en) | 1979-11-28 |
| DE2546667C3 (en) | 1978-10-12 |
| AU1724576A (en) | 1978-03-02 |
| NL7609652A (en) | 1977-04-19 |
| DE2546667B2 (en) | 1978-02-09 |
| AR210905A1 (en) | 1977-09-30 |
| FR2327786A1 (en) | 1977-05-13 |
| FR2327786B1 (en) | 1980-04-18 |
| MX4485E (en) | 1982-05-21 |
| BE846397A (en) | 1977-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |