GB1511187A - Chromans - Google Patents

Chromans

Info

Publication number
GB1511187A
GB1511187A GB13536/76A GB1353676A GB1511187A GB 1511187 A GB1511187 A GB 1511187A GB 13536/76 A GB13536/76 A GB 13536/76A GB 1353676 A GB1353676 A GB 1353676A GB 1511187 A GB1511187 A GB 1511187A
Authority
GB
United Kingdom
Prior art keywords
alkyl
optionally substituted
group
acyloxy
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13536/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB13536/76A priority Critical patent/GB1511187A/en
Priority to NZ183551A priority patent/NZ183551A/en
Priority to IL51648A priority patent/IL51648A/en
Priority to ZA00771516A priority patent/ZA771516B/en
Priority to DE2760316A priority patent/DE2760316C3/en
Priority to DE19772713670 priority patent/DE2713670A1/en
Priority to BE176178A priority patent/BE852955A/en
Priority to FR7709151A priority patent/FR2346346A1/en
Priority to CH394477A priority patent/CH632262A5/en
Priority to JP3603477A priority patent/JPS52122372A/en
Priority to NL7703440A priority patent/NL7703440A/en
Priority to SE7703715A priority patent/SE7703715L/en
Priority to ES457417A priority patent/ES457417A1/en
Priority to CA000275337A priority patent/CA1119180A/en
Priority to IE694/77A priority patent/IE44977B1/en
Priority to DK147777A priority patent/DK147777A/en
Priority to AU23875/77A priority patent/AU503934B2/en
Publication of GB1511187A publication Critical patent/GB1511187A/en
Priority to US05/970,199 priority patent/US4251537A/en
Priority to US06/198,280 priority patent/US4391815A/en
Priority to CA000376467A priority patent/CA1139765A/en
Priority to US06/442,355 priority patent/US4758677A/en
Priority to NL8402722A priority patent/NL8402722A/en
Priority to JP60250599A priority patent/JPS61129183A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1511187 Chromanes BEECHAM GROUP Ltd 23 March 1977 [2 April 1976 10 Aug 1976] 13536/76 and 33178/76 Heading C2C Compounds of the general Formula (I) (R 1 = H, C 1-4 alkyl optionally substituted by Cl, Br, OH or C 1-4 alkoxy or acyloxy; R 2 =H, C 1-4 alkyl or NR 1 R 2 =5-8 membered ring optionally substituted by one or more methyl groups; Y=COR 3 , CO 2 R 3 , SOR 3 , SO 2 R 3 , SO . OR 3 , SO 2 . OR 3 , CH(OH)R 3 , C(R 3 )NOH, C(R 3 )NNH 2 , CONH 2 , CONR 4 R 5 , SONR 4 R 5 , SO 2 NR 4 R 5 ; R 3,4 =C 1-8 hydrocarbyl optionally substituted by Cl, Br, OH, C 1-4 alkoxy or acyloxy, or by three fluorine atoms on the same carbon atom; R 5 = H, C 1-4 alkyl) and their esters and salts are prepared by reacting a corresponding 2,2 - dimethyl - 3,4 - epoxychromane (IV) with R 1 R 2 NH, optionally followed by (a) conversion of a ketone to its oxime, hydrazone or the corresponding secondary alcohol, (b) acylation and/or (c) salt formation. The starting material may be substituted by a precursor for Y, e.g. a cyano group which may be hydrolysed to a carbamoyl group. The starting materials are prepared by the following route (Y<SP>1</SP>= inert group Y, or precursor). The above compounds are antihypertensive agents, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
GB13536/76A 1976-04-02 1976-04-02 Chromans Expired GB1511187A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB13536/76A GB1511187A (en) 1976-04-02 1976-04-02 Chromans
NZ183551A NZ183551A (en) 1976-04-02 1977-03-09 Aminochromanols and pharmaceutical compositions containingthem
IL51648A IL51648A (en) 1976-04-02 1977-03-11 4-amino chromanol derivatives,their preparation and pharmaceutical compositions containing them
ZA00771516A ZA771516B (en) 1976-04-02 1977-03-14 Anti-hypertensive acylated amino chromanolo
DE2760316A DE2760316C3 (en) 1976-04-02 1977-03-28 Derivatives of 3,4-epoxy-3,4-dihydro-2,2-dimethyl-2H-benzo [b] pyran and their use for the preparation of 2H-benzo [b] pyran-3-ols
DE19772713670 DE2713670A1 (en) 1976-04-02 1977-03-28 AMINOCHROMANOL DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS
BE176178A BE852955A (en) 1976-04-02 1977-03-28 NEW AMINO-CHROMANOLS
FR7709151A FR2346346A1 (en) 1976-04-02 1977-03-28 NEW AMINO-CHROMANOLS
CH394477A CH632262A5 (en) 1976-04-02 1977-03-29 METHOD FOR PRODUCING AMINOCHROMANOL DERIVATIVES.
SE7703715A SE7703715L (en) 1976-04-02 1977-03-30 PREPARATION OF NEW AMINOCROMANOLS
NL7703440A NL7703440A (en) 1976-04-02 1977-03-30 PROCEDURE FOR PREPARING NEW AMINO CHROMANOL DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS.
JP3603477A JPS52122372A (en) 1976-04-02 1977-03-30 New aminochromanols and their preparation and medical composition containing same and having hypotensive effect
ES457417A ES457417A1 (en) 1976-04-02 1977-03-31 Hypotensive 3,4-dihydro-2,2-dimethyl-4-amino-2H-benzo[b]pyran-3-ols
AU23875/77A AU503934B2 (en) 1976-04-02 1977-04-01 Amino chomanols
IE694/77A IE44977B1 (en) 1976-04-02 1977-04-01 Chromans
DK147777A DK147777A (en) 1976-04-02 1977-04-01 PROCEDURE FOR MAKING ACYLCHROMANES
CA000275337A CA1119180A (en) 1976-04-02 1977-04-01 Derivatives of trans-3-hydroxy-4-amino-chromans
US05/970,199 US4251537A (en) 1976-04-02 1978-12-18 Hypotensive 3,4-dihydro-2,2-dimethyl-4-amino-2H-benzo[b]pyran-3-ols
US06/198,280 US4391815A (en) 1976-04-02 1980-10-17 Cyanobenzano[b]pyrans
CA000376467A CA1139765A (en) 1976-04-02 1981-04-28 Amino chromanols
US06/442,355 US4758677A (en) 1976-04-02 1982-11-17 Cyanobenzano [b] pyrans
NL8402722A NL8402722A (en) 1976-04-02 1984-09-06 PROCESS FOR PREPARING NEW EPOXY-BENZOPYRAN DERIVATIVES.
JP60250599A JPS61129183A (en) 1976-04-02 1985-11-08 Chroman derivative and manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13536/76A GB1511187A (en) 1976-04-02 1976-04-02 Chromans

Publications (1)

Publication Number Publication Date
GB1511187A true GB1511187A (en) 1978-05-17

Family

ID=10024759

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13536/76A Expired GB1511187A (en) 1976-04-02 1976-04-02 Chromans

Country Status (4)

Country Link
JP (1) JPS61129183A (en)
BE (1) BE852955A (en)
GB (1) GB1511187A (en)
ZA (1) ZA771516B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0046652A1 (en) * 1980-08-21 1982-03-03 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
US4327099A (en) 1980-02-02 1982-04-27 Beecham Group Limited Pyrano derivatives, a process for their preparation and their use
EP0076075A1 (en) * 1981-09-25 1983-04-06 Beecham Group Plc Pharmaceutically active benzopyran compounds
EP0091748A1 (en) * 1982-04-08 1983-10-19 Beecham Group Plc Antihypertensive benzopyranols
EP0107423A1 (en) * 1982-10-19 1984-05-02 Beecham Group Plc Novel chromans and chromenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327099A (en) 1980-02-02 1982-04-27 Beecham Group Limited Pyrano derivatives, a process for their preparation and their use
EP0033612B1 (en) * 1980-02-02 1984-04-11 Beecham Group Plc Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them
EP0046652A1 (en) * 1980-08-21 1982-03-03 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
US4481213A (en) * 1980-08-21 1984-11-06 Beecham Group Limited 4-Haloalkylamino substituted chromanol useful as antihypertensive agent
EP0076075A1 (en) * 1981-09-25 1983-04-06 Beecham Group Plc Pharmaceutically active benzopyran compounds
EP0091748A1 (en) * 1982-04-08 1983-10-19 Beecham Group Plc Antihypertensive benzopyranols
EP0107423A1 (en) * 1982-10-19 1984-05-02 Beecham Group Plc Novel chromans and chromenes

Also Published As

Publication number Publication date
BE852955A (en) 1977-09-28
JPS61129183A (en) 1986-06-17
ZA771516B (en) 1978-02-22
JPH0353314B2 (en) 1991-08-14

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee