GB1471336A - Process for the purification and sterilisation of acidophilic biologicals- - Google Patents
Process for the purification and sterilisation of acidophilic biologicals-Info
- Publication number
- GB1471336A GB1471336A GB1587474A GB1587474A GB1471336A GB 1471336 A GB1471336 A GB 1471336A GB 1587474 A GB1587474 A GB 1587474A GB 1587474 A GB1587474 A GB 1587474A GB 1471336 A GB1471336 A GB 1471336A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acidification
- hormones
- april
- human serum
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 2
- 102000004506 Blood Proteins Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 230000020477 pH reduction Effects 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 abstract 2
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 229930182566 Gentamicin Natural products 0.000 abstract 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- 108010019160 Pancreatin Proteins 0.000 abstract 1
- 108090000526 Papain Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- 108010074605 gamma-Globulins Proteins 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 229960000988 nystatin Drugs 0.000 abstract 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
- 229940055695 pancreatin Drugs 0.000 abstract 1
- 229940055729 papain Drugs 0.000 abstract 1
- 235000019834 papain Nutrition 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 229960005322 streptomycin Drugs 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
- 229960001322 trypsin Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1471336 Sterilizing acid-stable enzymes, hormones, human serum proteins and antibiotics ARMOUR PHARMACEUTICAL CO 10 April 1974 [16 April 1973 1 June 1973] 15874/74 Heading A2D [Also in Division C3] Acid-resistant enzymes, hormones, human serum proteins and antibiotics suspended or dissolved in a liquid carrier, such as water. saline or carbohydrate solution, are sterilized by acidification to a pH of from 1.25 to 2.5, storage at a temperature of from 4 to 70C for up to 48 hours to inactivate microbial flora and then neutralization. Examples illustrate the sterilization of liquids containing trypsin, chymotrypsin, papain, pancreatin, streptomycin, gentamycin, kanomycin, erythromycin, tetracycline, gamma globulin and nystatin. Acids used for acidification are hydrochloric. sulphuric, sulphurous, oxalic and nitric acids.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35153873A | 1973-04-16 | 1973-04-16 | |
| US36600373A | 1973-06-01 | 1973-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1471336A true GB1471336A (en) | 1977-04-21 |
Family
ID=26997143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1587474A Expired GB1471336A (en) | 1973-04-16 | 1974-04-10 | Process for the purification and sterilisation of acidophilic biologicals- |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1471336A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2309239A1 (en) * | 1975-04-28 | 1976-11-26 | Armour Pharma | PROCESS FOR PURIFICATION AND STERILIZATION OF BIOLOGICAL ACIDOPHILIC PRODUCTS BY HIGH ACIDIFICATION AT LOW TEMPERATURE |
| US4456590A (en) * | 1981-11-02 | 1984-06-26 | Cedars Sinai Medical Center | Heat treatment of lyophilized blood clotting factor VIII concentrate |
| US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| US4556558A (en) * | 1982-05-13 | 1985-12-03 | Cedars-Sinai Medical Center | Treatment of factor VIII concentrate to minimize the affect of undesirable microorganisms |
| US4845074A (en) * | 1982-05-13 | 1989-07-04 | Cedars Sinai Medical Center | Heat treatment of Factor VIII |
| WO1991016082A1 (en) * | 1990-04-18 | 1991-10-31 | Burghard Bohn | Decontaminated biological material |
| EP0457035A1 (en) * | 1990-05-17 | 1991-11-21 | Dr. Karl Thomae GmbH | Method for inactivating biological activity of DNA |
| US5637450A (en) * | 1990-04-18 | 1997-06-10 | Bohn; Burghard | Decontaminated serum and method of production therefor |
-
1974
- 1974-04-10 GB GB1587474A patent/GB1471336A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2309239A1 (en) * | 1975-04-28 | 1976-11-26 | Armour Pharma | PROCESS FOR PURIFICATION AND STERILIZATION OF BIOLOGICAL ACIDOPHILIC PRODUCTS BY HIGH ACIDIFICATION AT LOW TEMPERATURE |
| US4495278A (en) * | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| EP0077355B1 (en) * | 1981-04-27 | 1988-11-23 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Process for making blood clotting enzyme compositions |
| US4456590A (en) * | 1981-11-02 | 1984-06-26 | Cedars Sinai Medical Center | Heat treatment of lyophilized blood clotting factor VIII concentrate |
| US4556558A (en) * | 1982-05-13 | 1985-12-03 | Cedars-Sinai Medical Center | Treatment of factor VIII concentrate to minimize the affect of undesirable microorganisms |
| US4845074A (en) * | 1982-05-13 | 1989-07-04 | Cedars Sinai Medical Center | Heat treatment of Factor VIII |
| WO1991016082A1 (en) * | 1990-04-18 | 1991-10-31 | Burghard Bohn | Decontaminated biological material |
| AU660410B2 (en) * | 1990-04-18 | 1995-06-29 | Burghard Bohn | Decontaminated biological material |
| US5637450A (en) * | 1990-04-18 | 1997-06-10 | Bohn; Burghard | Decontaminated serum and method of production therefor |
| EP0457035A1 (en) * | 1990-05-17 | 1991-11-21 | Dr. Karl Thomae GmbH | Method for inactivating biological activity of DNA |
| US5417862A (en) * | 1990-05-17 | 1995-05-23 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Process for inactivating the biological activity of DNA |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |