GB1468758A - Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field - Google Patents

Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field

Info

Publication number
GB1468758A
GB1468758A GB2409074A GB2409074A GB1468758A GB 1468758 A GB1468758 A GB 1468758A GB 2409074 A GB2409074 A GB 2409074A GB 2409074 A GB2409074 A GB 2409074A GB 1468758 A GB1468758 A GB 1468758A
Authority
GB
United Kingdom
Prior art keywords
pinol
cineole
dihydroxy
sobrerol
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2409074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CORVI C SpA
Original Assignee
CORVI C SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CORVI C SpA filed Critical CORVI C SpA
Publication of GB1468758A publication Critical patent/GB1468758A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1468758 Preparation of 2,6-dihydroxycineole CAMILLO CORVI SpA 30 May 1974 [12 June 1973 10 April 1974] 24090/74 Heading C2C Very pure 2,6-dihydroxy-cineole is prepared by reacting very pure sobrerol with a mineral or organic acid to give pinol, reacting the pinol with a peracid to give pinol epoxide of at least 98% purity and hydrolysing this in aqueous or aqueous/alcoholic solution using a mineral or organic acid. The processes may be illustrated by the reaction sequence: Pharmaceutical compositions having choleretic activity comprise the 2,6-dihydroxy-cineole prepared by the above process together with a suitable carrier or diluent.
GB2409074A 1973-06-12 1974-05-30 Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field Expired GB1468758A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2512773 1973-06-12
IT2120574 1974-04-10

Publications (1)

Publication Number Publication Date
GB1468758A true GB1468758A (en) 1977-03-30

Family

ID=26327823

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4347676A Expired GB1469921A (en) 1973-06-12 1974-05-30 Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field
GB2409074A Expired GB1468758A (en) 1973-06-12 1974-05-30 Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4347676A Expired GB1469921A (en) 1973-06-12 1974-05-30 Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field

Country Status (7)

Country Link
JP (1) JPS5944316B2 (en)
AR (2) AR202410A1 (en)
CH (1) CH605965A5 (en)
DE (2) DE2428039C3 (en)
ES (1) ES427240A1 (en)
GB (2) GB1469921A (en)
NL (3) NL176745C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554366A (en) * 1982-09-13 1985-11-19 Shell Oil Company Certain substituted, 7-oxabicyclo[2.2.1]heptan-2-ols and -2-ones as intermediates

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542244A (en) * 1982-09-13 1985-09-17 Shell Oil Company Oxabicycloalkane herbicides
JPS61181403A (en) * 1985-02-06 1986-08-14 島村　▲てい▼次郎 Stick

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554366A (en) * 1982-09-13 1985-11-19 Shell Oil Company Certain substituted, 7-oxabicyclo[2.2.1]heptan-2-ols and -2-ones as intermediates

Also Published As

Publication number Publication date
JPS5944316B2 (en) 1984-10-29
NL176745C (en) 1985-06-03
DE2428039C3 (en) 1981-12-24
JPS5035155A (en) 1975-04-03
ES427240A1 (en) 1976-09-01
DE2428039B2 (en) 1980-10-30
DE2462947C2 (en) 1986-08-28
NL8403477A (en) 1985-03-01
GB1469921A (en) 1977-04-06
CH605965A5 (en) 1978-10-13
AR202410A1 (en) 1975-06-06
AR202506A1 (en) 1975-06-13
NL8403481A (en) 1985-03-01
NL176745B (en) 1985-01-02
DE2428039A1 (en) 1975-01-09
NL7407862A (en) 1974-12-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee