GB1390032A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB1390032A
GB1390032A GB4042771A GB4042771A GB1390032A GB 1390032 A GB1390032 A GB 1390032A GB 4042771 A GB4042771 A GB 4042771A GB 4042771 A GB4042771 A GB 4042771A GB 1390032 A GB1390032 A GB 1390032A
Authority
GB
United Kingdom
Prior art keywords
weight
component
aug
ester
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4042771A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SWG Ltd
Original Assignee
Sterling Winthrop Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Group Ltd filed Critical Sterling Winthrop Group Ltd
Priority to GB4042771A priority Critical patent/GB1390032A/en
Priority to AU45845/72A priority patent/AU4584572A/en
Priority to ZA725791A priority patent/ZA725791B/en
Priority to DK423272AA priority patent/DK131418B/en
Priority to DE2241960A priority patent/DE2241960C2/en
Priority to CA150,153A priority patent/CA988424A/en
Priority to FR7230504A priority patent/FR2150903B1/fr
Publication of GB1390032A publication Critical patent/GB1390032A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1390032 Paracetamol formulations STERLING-WINTHROP GROUP Ltd 23 Nov 1972 [27 Aug 1971 29 Aug 1972] 40427/71 and 40075/72 Heading A5B A free-flowing granular material, suitable for tabletting and comprising (a) more than 80% by weight of an N-acylaminophenol or an ester thereof and (b) from 1.5% to 10% by weight, on the weight of component (a), of a water-soluble polymeric organic binder, may be prepared by spray-drying an aqueous fluid comprising (a) and (b). The material preferably has a water content of from 0.4% to 2.0% by weight. Component (a) may be paracetamol, metacetamol or the acetylsalicylic ester thereof and component (b) may be polyvinylpyrrolidone, polyvinyl alcohol, a copolymer of vinyl alcohol, vinyl acetate and/or vinyl pyrrolidone, or a cellulose derivative such as hydroxyethyl-, hydroxypropyl- and sodium carboxymethyl cellulose. The material may also comprise up to 7% by weight on the weight of component a) of a starch or derivative thereof or a sugar or sugar alcohol e.g. maize starch, dextrin, glucose, sucrose, sorbitol or mannitol; and/or a preservative for component (a) e.g. potassium sorbate or benzoic acid or its derivatives.
GB4042771A 1971-08-27 1971-08-27 Pharmaceutical compositions Expired GB1390032A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB4042771A GB1390032A (en) 1971-08-27 1971-08-27 Pharmaceutical compositions
AU45845/72A AU4584572A (en) 1971-08-27 1972-08-22 Free-flowing granular material
ZA725791A ZA725791B (en) 1971-08-27 1972-08-22 Granular material suitable for tabletting free-flowing comprising n-acylamino-phenol and water-soluble polymeric organic binder
DK423272AA DK131418B (en) 1971-08-27 1972-08-25 Method for preparing and optionally tableting a free-flowing granular material suitable for tableting.
DE2241960A DE2241960C2 (en) 1971-08-27 1972-08-25 Free-flowing granules for tablet production
CA150,153A CA988424A (en) 1971-08-27 1972-08-25 Pharmaceutical compositions of n-acylaminophenol in a suitable form for tabletting
FR7230504A FR2150903B1 (en) 1971-08-27 1972-08-28

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4042771A GB1390032A (en) 1971-08-27 1971-08-27 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
GB1390032A true GB1390032A (en) 1975-04-09

Family

ID=10414863

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4042771A Expired GB1390032A (en) 1971-08-27 1971-08-27 Pharmaceutical compositions

Country Status (7)

Country Link
AU (1) AU4584572A (en)
CA (1) CA988424A (en)
DE (1) DE2241960C2 (en)
DK (1) DK131418B (en)
FR (1) FR2150903B1 (en)
GB (1) GB1390032A (en)
ZA (1) ZA725791B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5753403A (en) * 1980-05-20 1982-03-30 Mallinckrodt Chemical Works Composition containing spray dry particle of n-acetyl-p-aminophenol and manufacture
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
AU574345B2 (en) * 1982-07-06 1988-07-07 Sterling Drug Inc. Preparing compressed tablets by wet granulation and tablets therefrom
US4757090A (en) * 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
WO1989002266A1 (en) * 1987-09-17 1989-03-23 Mallinckrodt, Inc. A free-flowing granular composition containing ibuprofen and a method for its preparation
WO1994020086A1 (en) * 1993-03-12 1994-09-15 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof
US9724302B2 (en) 2010-04-09 2017-08-08 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR226763A1 (en) * 1980-12-22 1982-08-13 Monsanto Co PREPARATION METHOD FOR AN ANALGESIC GRANULATION OF ACETAMINOPHEN
DE3215211A1 (en) * 1982-04-23 1983-10-27 Akzo Gmbh MICROPOROISIS POWDER LOADED WITH ACTIVE SUBSTANCES
DE3447422A1 (en) * 1984-12-24 1986-06-26 Basf Ag, 6700 Ludwigshafen METHOD FOR THE PRODUCTION OF ASCORBIN ACID GRANULES
JPH0780754B2 (en) * 1986-08-06 1995-08-30 エーザイ株式会社 Multi-granular sustained-release tablet
US4820522A (en) * 1987-07-27 1989-04-11 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
DE19835124C2 (en) * 1998-08-04 2002-01-03 Buna Sow Leuna Olefinverb Gmbh Process for the production of starch esters with a defined grain structure for pharmaceutical purposes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3200039A (en) * 1962-05-28 1965-08-10 Pfizer & Co C Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0354083B2 (en) * 1980-05-20 1991-08-19
JPS5753403A (en) * 1980-05-20 1982-03-30 Mallinckrodt Chemical Works Composition containing spray dry particle of n-acetyl-p-aminophenol and manufacture
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
AU574345B2 (en) * 1982-07-06 1988-07-07 Sterling Drug Inc. Preparing compressed tablets by wet granulation and tablets therefrom
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4631284A (en) * 1984-11-19 1986-12-23 Mallinckrodt, Inc. Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom
US4757090A (en) * 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
WO1989002266A1 (en) * 1987-09-17 1989-03-23 Mallinckrodt, Inc. A free-flowing granular composition containing ibuprofen and a method for its preparation
WO1994020086A1 (en) * 1993-03-12 1994-09-15 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof
US9724302B2 (en) 2010-04-09 2017-08-08 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9730892B2 (en) 2010-04-09 2017-08-15 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9737483B2 (en) 2010-04-09 2017-08-22 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9737482B2 (en) 2010-04-09 2017-08-22 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9757336B2 (en) 2010-04-09 2017-09-12 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US9808424B2 (en) 2010-04-09 2017-11-07 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US10045941B2 (en) 2010-04-09 2018-08-14 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles
US10398648B2 (en) 2010-04-09 2019-09-03 Pacira Pharmaceuticals, Inc. Method for formulating large diameter synthetic membrane vesicles

Also Published As

Publication number Publication date
DE2241960A1 (en) 1973-03-15
FR2150903B1 (en) 1975-10-17
CA988424A (en) 1976-05-04
DK131418B (en) 1975-07-14
AU4584572A (en) 1974-02-28
ZA725791B (en) 1973-05-30
DE2241960C2 (en) 1982-02-04
DK131418C (en) 1975-12-01
FR2150903A1 (en) 1973-04-13

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee