GB1357212A - Benzothiophene derivatives and process for preparing the same - Google Patents

Benzothiophene derivatives and process for preparing the same

Info

Publication number
GB1357212A
GB1357212A GB3003271A GB3003271A GB1357212A GB 1357212 A GB1357212 A GB 1357212A GB 3003271 A GB3003271 A GB 3003271A GB 3003271 A GB3003271 A GB 3003271A GB 1357212 A GB1357212 A GB 1357212A
Authority
GB
United Kingdom
Prior art keywords
formula
reaction
compound
june
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3003271A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Priority to GB3003271A priority Critical patent/GB1357212A/en
Priority to BE784260A priority patent/BE784260A/en
Priority to FI1578/72A priority patent/FI54477C/en
Priority to ZA723868A priority patent/ZA723868B/en
Priority to IE790/72A priority patent/IE36485B1/en
Priority to HULA799A priority patent/HU166255B/hu
Priority to AU43338/72A priority patent/AU462617B2/en
Priority to CH1795273A priority patent/CH548409A/en
Priority to CH930272A priority patent/CH549042A/en
Priority to SE7208187A priority patent/SE385482B/en
Priority to FR7222480A priority patent/FR2143250B1/fr
Priority to CA145,600A priority patent/CA959492A/en
Priority to DE19722230669 priority patent/DE2230669A1/en
Priority to SU721959344A priority patent/SU486510A3/en
Priority to SU1800666A priority patent/SU453844A3/ru
Priority to NL7208703A priority patent/NL7208703A/xx
Priority to JP47063621A priority patent/JPS4844248A/ja
Priority to ES404252A priority patent/ES404252A1/en
Priority to AT545972A priority patent/AT312597B/en
Priority to OA54619A priority patent/OA04117A/en
Publication of GB1357212A publication Critical patent/GB1357212A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1357212 Benzothiapine derivatives LABAZ 16 June 1972 [25 June 1971] 30032/71 Heading C2C Novel compounds of Formula I and the pharmaceutically acceptable acid addition salts thereof, for example the oxalate or hydrochloride, wherein R represents hydrogen or a branched or straight-chain alkyl group containing from 1 to 4 carbon atoms, R<SP>1</SP> represents hydrogen or methyl, X and X 1 , which are identical, each represent an atom of chlorine, bromine or iodine, Am represents a dimethylamino, diethylamino, di - n - propylamino, di - n - butylamino, pyrrolidino, piperidino or perhydroazepino group, and n is an integer in the range of from I to 5 inclusive are prepared by reaction of HAm with a compound of Formula IV or in the case where n is 1 or 2 by reaction of a compound II with (Z is halogen or tosyloxy). Intermediates of Formula IV above are prepared by reaction of with an intermediate of Formula II above obtained by the demethylation of the corresponding methyl ether starting material followed by halogenation. Pharmaceutical compositions in conventional forms for oral or rectal administration comprise an above novel compound and a carrier or diluent. The compositions are of use in the treatment of heart conditions.
GB3003271A 1971-06-25 1971-06-25 Benzothiophene derivatives and process for preparing the same Expired GB1357212A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB3003271A GB1357212A (en) 1971-06-25 1971-06-25 Benzothiophene derivatives and process for preparing the same
BE784260A BE784260A (en) 1971-06-25 1972-06-01 NEW DERIVATIVES OF BENZO (B) THIOPHENE AND THERAPEUTIC COMPOSITIONS CONTAINING THEM AS WELL AS THE PROCESSES FOR THE PREPARATION OF DERIVATIVES AND COMPOSITIONS
FI1578/72A FI54477C (en) 1971-06-25 1972-06-05 FRAMEWORK FOR THE PHARMACOLOGICAL ACTIVATION OF ACTIVE 3-BENZOYL-BENZO (B) THIOFENDERIVAT
ZA723868A ZA723868B (en) 1971-06-25 1972-06-06 Heterocyclic compounds and process for preparing the same
IE790/72A IE36485B1 (en) 1971-06-25 1972-06-07 Benzothiophene derivatives and process for preparing same
HULA799A HU166255B (en) 1971-06-25 1972-06-13
AU43338/72A AU462617B2 (en) 1971-06-25 1972-06-13 Heterocyclic compounds and process for preparing thesame
CH1795273A CH548409A (en) 1971-06-25 1972-06-21 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF BENZO (B) THIOPHENE.
CH930272A CH549042A (en) 1971-06-25 1972-06-21 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF BENZO (B) THIOPHENE.
SE7208187A SE385482B (en) 1971-06-25 1972-06-21 PROCEDURE FOR THE PRODUCTION OF BASIC SUBSTITUTED 3-BENZOYL-BENZO (B) THIOFEN DERIVATIVES
FR7222480A FR2143250B1 (en) 1971-06-25 1972-06-22
CA145,600A CA959492A (en) 1971-06-25 1972-06-23 Benzo (b) thiophene derivatives and pharmaceutical compositions containing the same
DE19722230669 DE2230669A1 (en) 1971-06-25 1972-06-23 New benzo (b) thiophene derivatives, processes for their production and pharmaceutical preparations containing them
SU721959344A SU486510A3 (en) 1971-06-25 1972-06-23 The method of obtaining derivatives of benzo / in / thiophene or their salts
SU1800666A SU453844A3 (en) 1971-06-25 1972-06-23
NL7208703A NL7208703A (en) 1971-06-25 1972-06-23
JP47063621A JPS4844248A (en) 1971-06-25 1972-06-24
ES404252A ES404252A1 (en) 1971-06-25 1972-06-24 Benzothiophene derivatives and process for preparing the same
AT545972A AT312597B (en) 1971-06-25 1972-06-26 Process for the preparation of new benzo [b] thiophene derivatives and their salts
OA54619A OA04117A (en) 1971-06-25 1972-06-26 Process for the preparation of new derivatives of Burgo (b) tiophéine.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3003271A GB1357212A (en) 1971-06-25 1971-06-25 Benzothiophene derivatives and process for preparing the same

Publications (1)

Publication Number Publication Date
GB1357212A true GB1357212A (en) 1974-06-19

Family

ID=10301169

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3003271A Expired GB1357212A (en) 1971-06-25 1971-06-25 Benzothiophene derivatives and process for preparing the same

Country Status (18)

Country Link
JP (1) JPS4844248A (en)
AT (1) AT312597B (en)
AU (1) AU462617B2 (en)
BE (1) BE784260A (en)
CA (1) CA959492A (en)
CH (2) CH549042A (en)
DE (1) DE2230669A1 (en)
ES (1) ES404252A1 (en)
FI (1) FI54477C (en)
FR (1) FR2143250B1 (en)
GB (1) GB1357212A (en)
HU (1) HU166255B (en)
IE (1) IE36485B1 (en)
NL (1) NL7208703A (en)
OA (1) OA04117A (en)
SE (1) SE385482B (en)
SU (2) SU486510A3 (en)
ZA (1) ZA723868B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534582A1 (en) * 1982-10-19 1984-04-20 Kotobuki Seiyaku Co Ltd NOVEL BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, USEFUL AS ANTI-HYPERURICEMIA AND ANTI-HYPERTENSION AGENTS, AND PROCESS FOR THEIR MANUFACTURE
EP0181568A2 (en) * 1984-10-30 1986-05-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds
EP0675121A1 (en) * 1994-03-31 1995-10-04 Eli Lilly And Company Novel intermediates and processes for preparing benzothiophene compounds
EP0875507A1 (en) * 1997-04-30 1998-11-04 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534582A1 (en) * 1982-10-19 1984-04-20 Kotobuki Seiyaku Co Ltd NOVEL BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, USEFUL AS ANTI-HYPERURICEMIA AND ANTI-HYPERTENSION AGENTS, AND PROCESS FOR THEIR MANUFACTURE
US4797415A (en) * 1982-10-19 1989-01-10 Kotobuki Seiyaku Company Limited Benzofuran derivatives and use thereof for treating hyperuricemia
EP0181568A2 (en) * 1984-10-30 1986-05-21 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds
EP0181568A3 (en) * 1984-10-30 1989-04-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-inflammatory/anti-allergic compounds
EP0675121A1 (en) * 1994-03-31 1995-10-04 Eli Lilly And Company Novel intermediates and processes for preparing benzothiophene compounds
EP0875507A1 (en) * 1997-04-30 1998-11-04 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals

Also Published As

Publication number Publication date
CH549042A (en) 1974-05-15
AU462617B2 (en) 1975-06-10
ES404252A1 (en) 1975-06-01
AT312597B (en) 1974-01-10
AU4333872A (en) 1973-12-20
FR2143250A1 (en) 1973-02-02
JPS4844248A (en) 1973-06-26
FI54477C (en) 1978-12-11
FI54477B (en) 1978-08-31
NL7208703A (en) 1972-12-28
FR2143250B1 (en) 1975-06-20
DE2230669A1 (en) 1972-12-28
HU166255B (en) 1975-02-28
IE36485L (en) 1972-12-25
CH548409A (en) 1974-04-30
SU486510A3 (en) 1975-09-30
ZA723868B (en) 1973-03-28
OA04117A (en) 1979-11-30
BE784260A (en) 1972-12-01
IE36485B1 (en) 1976-11-10
CA959492A (en) 1974-12-17
SE385482B (en) 1976-07-05
SU453844A3 (en) 1974-12-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee