GB1321424A - N-phenyl-n-disubstituted aminoalkyl-2-amino indanes - Google Patents

N-phenyl-n-disubstituted aminoalkyl-2-amino indanes

Info

Publication number
GB1321424A
GB1321424A GB6207369A GB1321424DA GB1321424A GB 1321424 A GB1321424 A GB 1321424A GB 6207369 A GB6207369 A GB 6207369A GB 1321424D A GB1321424D A GB 1321424DA GB 1321424 A GB1321424 A GB 1321424A
Authority
GB
United Kingdom
Prior art keywords
formula
reacted
amine
compound
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6207369A
Inventor
P Vanhoof
P Clarebout
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Christiaens SA
Original Assignee
A Christiaens SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Christiaens SA filed Critical A Christiaens SA
Publication of GB1321424A publication Critical patent/GB1321424A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/53—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having the nitrogen atom of at least one of the amino groups further bound to a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1321424 N-Phenyl-N-disubstituted amino alkyl-2-amino-indanes MANUFACTURE DE PRODUITS PHARMACEUTIQUES A CHRISTIAENS SA 26 Nov 1970 [19 Dec 1969] 62073/69 Heading C2C Novel compounds of formula wherein n is 2 or 3, R 1 and R 2 are C 1 -C 4 alkyl or together with the adjacent nitrogen atom form a heterocyclic ring and R 3 is phenyl optionally substituted by e.g. methyl, methoxy, Cl or CF 3 and acid addition salts thereof, are prepared by reaction of a compound of Formula II with NaNH 2 and Cl(CR 2 ) n N.R 1 .R 2 and optional salt formation. Intermediates of Formula II are prepared by one of the following methods (a) an amine R 3 NH 2 is reacted with a 2-keto-3-cyanoindene and the product reduced by the Bouveault-Blanc method, (b) an amine R 3 NH 2 is reacted with a compound of formula or (c) 2-indanone is reacted with an amine R 3 NH 2 and NaBH 4 is then added to the reaction mixture. Pharmaceutical compositions in conventional forms for topical, parenteral or rectal administration and having local anaesthetic activity or use in treating heart arrhythmia comprise an above novel compound and a suitable carrier or diluent.
GB6207369A 1969-12-19 1969-12-19 N-phenyl-n-disubstituted aminoalkyl-2-amino indanes Expired GB1321424A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6207369 1969-12-19

Publications (1)

Publication Number Publication Date
GB1321424A true GB1321424A (en) 1973-06-27

Family

ID=10487848

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6207369A Expired GB1321424A (en) 1969-12-19 1969-12-19 N-phenyl-n-disubstituted aminoalkyl-2-amino indanes

Country Status (9)

Country Link
AT (1) AT298478B (en)
BE (1) BE760018A (en)
CH (1) CH521941A (en)
ES (1) ES386586A1 (en)
FR (1) FR2081383B1 (en)
GB (1) GB1321424A (en)
LU (1) LU62232A1 (en)
NL (1) NL150099B (en)
SE (1) SE372258B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2191999A (en) * 1986-06-19 1987-12-31 Squibb & Sons Inc p-Aminophenols, derivatives thereof and method of use
EP1185267A1 (en) * 1999-06-10 2002-03-13 Bridge Pharma, Inc. Dermal anesthetic agents
EP1658847A2 (en) * 1999-06-10 2006-05-24 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US8865741B2 (en) 2011-02-18 2014-10-21 Asana Biosciences, Llc Aminoindane compounds and use thereof in treating pain
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206999A1 (en) * 1972-11-06 1976-09-09 Christiaens Sa A PROCEDURE FOR THE PREPARATION OF NEW N-PHENYL-2-AMINOINDANE DERIVATIVES
GB1468347A (en) * 1973-03-02 1977-03-23 Christiaens Sa A Aminoindanes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670371A (en) * 1951-08-01 1954-02-23 Searle & Co Basic alkyl substitution products of n-indanyl and n-tetrahydronaphthyl-monocarbocyclylamides and their salts

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2191999A (en) * 1986-06-19 1987-12-31 Squibb & Sons Inc p-Aminophenols, derivatives thereof and method of use
EP1185267A1 (en) * 1999-06-10 2002-03-13 Bridge Pharma, Inc. Dermal anesthetic agents
US6413987B1 (en) * 1999-06-10 2002-07-02 Bridge Pharma, Inc. Dermal anesthetic agents
EP1185267A4 (en) * 1999-06-10 2003-09-03 Bridge Pharma Inc Dermal anesthetic agents
EP1658847A2 (en) * 1999-06-10 2006-05-24 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
EP1658847A3 (en) * 1999-06-10 2006-07-26 Bridge Pharma, Inc. Indane derivatives as dermal anesthetic agents
US7718674B2 (en) 2004-09-27 2010-05-18 Bridge Pharma, Inc. Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine
US7592458B2 (en) 2006-07-21 2009-09-22 Wright George E Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
US8865741B2 (en) 2011-02-18 2014-10-21 Asana Biosciences, Llc Aminoindane compounds and use thereof in treating pain
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
US9375423B2 (en) 2012-08-15 2016-06-28 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis

Also Published As

Publication number Publication date
FR2081383B1 (en) 1975-04-18
DE2060721A1 (en) 1971-06-24
ES386586A1 (en) 1973-11-16
AT298478B (en) 1972-05-10
SE372258B (en) 1974-12-16
LU62232A1 (en) 1971-05-11
CH521941A (en) 1972-04-30
NL150099B (en) 1976-07-15
DE2060721B2 (en) 1976-02-26
NL7018508A (en) 1971-06-22
BE760018A (en) 1971-06-08
FR2081383A1 (en) 1971-12-03

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLE Entries relating assignments, transmissions, licences in the register of patents
PCNP Patent ceased through non-payment of renewal fee