GB1314051A - Polypeptides and their derivatives - Google Patents

Polypeptides and their derivatives

Info

Publication number
GB1314051A
GB1314051A GB2477970A GB1314051DA GB1314051A GB 1314051 A GB1314051 A GB 1314051A GB 2477970 A GB2477970 A GB 2477970A GB 1314051D A GB1314051D A GB 1314051DA GB 1314051 A GB1314051 A GB 1314051A
Authority
GB
United Kingdom
Prior art keywords
thr
leu
ser
boc
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2477970A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH995769A external-priority patent/CH515216A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1314051A publication Critical patent/GB1314051A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1314051 Polypeptides SANDOZ Ltd 22 May 1970 [3 June 1969 20 June 1969 (4) 23 June 1969 (3) 26 June 1969 30 June 1969 9 Sept 1969] 24779/70 Heading C2C Novel compounds I: S - CH 2 - CHX - CO - ser - asn - leu - ser - thr - cys - val - leu - gly - lys - leu - ser - gln - glu - leu - hislys - leu - gln - thr - tyr - pro - arg - thr - asnthr-gly-ser-gly-thr-Y wherein X is H, NH 2 , RCONH or R<SP>1</SP>OCONH; R is alkyl or optionally substituted aryl or aralkyl; R<SP>1</SP> is alkyl, alkenyl or optionally substituted aryl or aralkyl; and Y is -pro-NH 2 or -pro-val-NH 2 ; wherein the terminal peptide unit -S-CH 2 -CHX-CO- has the L-configuration where X is NH 2 , RCONH or R<SP>1</SP>OCONH; and wherein ser may be exchanged for thr or ala; asn for asp, gln or glu; thr for ser or ala; lys for lys(BOC), orn; asn or asp; glu for glu(OtBn), gln, asn or asp; leu for tyr; tyr for phe and arg for orn or lys, provided that when sequence is asin I, and Y is -pro-NH 2 , X is other than NH 2 , are prepared by normal methods of peptide synthesis. Intermediates isolated are Z- or H-thr-pro- NH 2 .HCl; Z-ser-gly-(OEt or NHNH 2 ); Z- or H - ser - gly - thr - pro - NH 2 ; Z - asn - thr - gly- OEt; Z - thr - asn - thr - gly - OEt; BOC- arg(NO 2 ) -thr - asn - thr - gly - (OEt or NHNH 2 ); (BOC or H) - arg - thr - asn - thr - gly - ser - glythr - pro - NH 2 ; (Z- or H-) thr - tyr - pro - (OH or OMe); Z-leu-gln-OMe; H-gln-OMe.HCl; Z- lys(BOC) - leu - gln - OMe: Z - his - lys(BOC)- leu - gln - (OMe or NHNH 2 ); Z - his - lys(BOC)- leu - gln - thr - tyr - pro - OH; Z - gln - thr - tyrpro - OH; Z - lys(BOC) - tyr(OMe); Z - hislys(BOC) - tyr - NHNH 2 ; Z - his - lys(BOC)- tyr - gln - thr - tyr - pro - OH; (Z or H) - hislys(BOC) - leu - gln - thr - tyr - pro - arg - thrasn - thr - gly - ser - gly - thr - pro - NH 2 ; H- his - lys(BOC) - tyr - gln - thr - tyr - pro - argthr - asn - thr - gly - ser - gly - thr - pro - NH 2 ; (H or Z) - glu(OtBn) - leu - OMe; (Z or H) - glnglu(OtBu) - leu - OMe; Z - lys(BOC) - leu - ser- OMe; trityl - gly - lys(BOC) - leu - ser - NHNH 2 ; trityl - gly - lys(BOC) - leu - ser - gln - glu(OtBn)- leu - (NHNH 2 or OMe); H - gly - lys(BOC) - leuser - gln - glu(OtBn) - leu - his - lys(BOC) - leugln - thr - tyr - pro - arg - thr - asn - thr - gly- ser - gly - thr - pro - NH 2 ; (H or Z) - gln - leu- OMe; (H or Z) - glu - gln - leu - OMe; tritylgly - lys(BOC) - leu - ser - gin - gln - leu- NHNH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - leu - gln - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glnglu(OtBu) - leu - his - lys(BOC) - tyr - glu - thrtyr - pro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - tyr - gin - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; (H or Z) - cys(Bz) - val - leu - OMe; (H or Z) - thr - cys(Bz) - val - leu - OMe; H - thrcys(Bz) - val - leu - OH; (BOC or H) - asn - leuser - OMe; (BOC or H) - ser - asn - leu - ser- OMe; BOC - cys(Bz) - ser - asn - leu - ser- (NHNH 2 or OMe); BOC - cys - ser - asn - leuser - thr - cys - val - leu - OH; BOC - cys(Bz)- ser - asnleu - ser - thr - cys(Bz) - val - leu - OH; BOC - cys - ser - asn - leu-ser-thr-cys-val-leu- OH; pivaloyl - cys - ser - asn - leu - ser - thr - cysval-leu-OH; pivalic acid p-nitrophenyl ester; ethoxycarbonyl - cys - ser - arn - leu - ser - thr - cys - val-leu-OH; carbonic acid p-nitrophenyl ethyl ester; benzylmercaptopropionyl-ser-asn-leu-ser- # NHNH 2 ; and S-CH 2 CH 2 CO-ser - asn - leuser-thr-cys-val-leu-NHNH 2 . Pharmaceutical compositions comprise a compound I together with a suitable carrier and/or diluent and lower the calcium content in the blood.
GB2477970A 1969-06-03 1970-05-22 Polypeptides and their derivatives Expired GB1314051A (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
CH840569 1969-06-03
CH946169 1969-06-20
CH945369 1969-06-20
CH945169 1969-06-20
CH945269 1969-06-20
CH956069 1969-06-23
CH956169 1969-06-23
CH955969 1969-06-23
CH979269 1969-06-26
CH995769A CH515216A (en) 1969-06-30 1969-06-30 Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties
CH1361269 1969-09-09

Publications (1)

Publication Number Publication Date
GB1314051A true GB1314051A (en) 1973-04-18

Family

ID=27581430

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2477970A Expired GB1314051A (en) 1969-06-03 1970-05-22 Polypeptides and their derivatives

Country Status (9)

Country Link
JP (1) JPS5429513B1 (en)
CA (1) CA967950A (en)
DK (1) DK144563C (en)
FI (1) FI54800C (en)
GB (1) GB1314051A (en)
HK (1) HK52476A (en)
IE (1) IE35077B1 (en)
IL (1) IL34630A (en)
NO (1) NO137087C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2130221A (en) * 1982-11-18 1984-05-31 Squibb & Sons Inc Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4663309A (en) * 1983-06-29 1987-05-05 University Patents, Inc. Novel peptide hormones with calcitonin-like activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2130221A (en) * 1982-11-18 1984-05-31 Squibb & Sons Inc Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4663309A (en) * 1983-06-29 1987-05-05 University Patents, Inc. Novel peptide hormones with calcitonin-like activity

Also Published As

Publication number Publication date
IL34630A (en) 1973-10-25
DK144563C (en) 1982-09-20
JPS5429513B1 (en) 1979-09-25
CA967950A (en) 1975-05-20
IE35077L (en) 1970-12-03
NO137087B (en) 1977-09-19
DK144563B (en) 1982-03-29
FI54800B (en) 1978-11-30
IE35077B1 (en) 1975-11-12
FI54800C (en) 1979-03-12
HK52476A (en) 1976-08-27
IL34630A0 (en) 1970-08-19
NO137087C (en) 1977-12-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years