GB1293446A - Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them - Google Patents

Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
GB1293446A
GB1293446A GB35787/70A GB3578770A GB1293446A GB 1293446 A GB1293446 A GB 1293446A GB 35787/70 A GB35787/70 A GB 35787/70A GB 3578770 A GB3578770 A GB 3578770A GB 1293446 A GB1293446 A GB 1293446A
Authority
GB
United Kingdom
Prior art keywords
quinuclidine derivatives
pharmaceutical compositions
sulphamoyl
polyfluoro
alkylsulphonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35787/70A
Inventor
Claude Gueremy
Christian Renault
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECH S ET D APPLIC SCIENT SOGE
Original Assignee
RECH S ET D APPLIC SCIENT SOGE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECH S ET D APPLIC SCIENT SOGE filed Critical RECH S ET D APPLIC SCIENT SOGE
Priority to GB35787/70A priority Critical patent/GB1293446A/en
Priority to BE769615A priority patent/BE769615A/en
Priority to FR7124956A priority patent/FR2100940B1/fr
Priority to CH1017771A priority patent/CH535770A/en
Priority to IL37340A priority patent/IL37340A/en
Priority to ZA714800A priority patent/ZA714800B/en
Priority to CA118,807*7A priority patent/CA946402A/en
Priority to AT634471A priority patent/AT311375B/en
Priority to AU31567/71A priority patent/AU464500B2/en
Priority to DE19712136763 priority patent/DE2136763A1/en
Priority to NL7110187A priority patent/NL7110187A/xx
Publication of GB1293446A publication Critical patent/GB1293446A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1293446 Quinuclidine derivatives SOC GENERALE DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES 12 July 1971 [23 July 1970] 35787/70 Heading C2C Novel quinuclidine derivatives of the formula in which X 1 , X 2 and X 3 each are H, halogen, trihalomethyl, C 1-4 alkoxy, N0 2 , NH 2 , C 1 _ 4 alkylamino, di - (C 1-4 alkyl) amino, C 1-4 alkanoylamino, C 1-4 acyl, CN, sulphamoyl, N-(C 1-4 alkyl)- sulphamoyl. C 1-4 alkylthio, C 1-4 alkylsulphonyl, polyfluoro-C 1-4 , alkylthio, or polyfluoro-C 1-4 alkylsulphonyl and R is H or an acyclic hydrocarbon group containing less than 5 carbon atoms and acid addition salts thereof are prepared by reacting a reactive derivative of the appropriate benzoic acids with 2-aminomethylquinuclidine. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above novel compounds in association with pharmaceutical carriers or diluents. The compounds possess central nervous system depressant activity.
GB35787/70A 1970-07-23 1970-07-23 Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them Expired GB1293446A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB35787/70A GB1293446A (en) 1970-07-23 1970-07-23 Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them
BE769615A BE769615A (en) 1970-07-23 1971-07-07 NEW AMINO HETEROCYCLE BENZAMIDES, PROCESS FOR OBTAINING THEM AND THEIR APPLICATIONS IN THERAPEUTICS
FR7124956A FR2100940B1 (en) 1970-07-23 1971-07-08
CH1017771A CH535770A (en) 1970-07-23 1971-07-08 Process for the preparation of 2-amino-methyl-quinuclidine benzamides
IL37340A IL37340A (en) 1970-07-23 1971-07-19 Quinuclidine derivatives,their preparation and pharmaceutical compositions containing them
ZA714800A ZA714800B (en) 1970-07-23 1971-07-20 Novel benzamides of heterocycle amines,process for their preparation and pharmaceutical compositions containing them
CA118,807*7A CA946402A (en) 1970-07-23 1971-07-21 Benzamides d'heterocycles amines, procede pour leur obtention et leurs applications en therapeutique
AT634471A AT311375B (en) 1970-07-23 1971-07-21 Process for the preparation of new quinuclidine derivatives and their salts
AU31567/71A AU464500B2 (en) 1970-07-23 1971-07-22 Novel benzamide derivatives
DE19712136763 DE2136763A1 (en) 1970-07-23 1971-07-22 Novel benzamides containing nitrogen-containing heterocycles and processes for making the same
NL7110187A NL7110187A (en) 1970-07-23 1971-07-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35787/70A GB1293446A (en) 1970-07-23 1970-07-23 Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1293446A true GB1293446A (en) 1972-10-18

Family

ID=10381553

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35787/70A Expired GB1293446A (en) 1970-07-23 1970-07-23 Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them

Country Status (11)

Country Link
AT (1) AT311375B (en)
AU (1) AU464500B2 (en)
BE (1) BE769615A (en)
CA (1) CA946402A (en)
CH (1) CH535770A (en)
DE (1) DE2136763A1 (en)
FR (1) FR2100940B1 (en)
GB (1) GB1293446A (en)
IL (1) IL37340A (en)
NL (1) NL7110187A (en)
ZA (1) ZA714800B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
US4797406A (en) * 1983-08-26 1989-01-10 Sandoz Ltd. Amides and esters containing bridged piperidines and use as serotonin M antagonists
US4803199A (en) * 1982-06-29 1989-02-07 Peter Donatsch Pharmaceutically useful heterocyclic and carbocyclic acid esters and amides of alkylene bridged piperidines
US4853376A (en) * 1985-10-19 1989-08-01 Beecham Group, P.L.C. Benzamides and benzoates having anti-emetic activity
WO1991007402A1 (en) * 1989-11-17 1991-05-30 Pfizer Inc. Azabicyclo amides and esters as 5-ht3 receptor antagonists
US5446050A (en) * 1989-11-17 1995-08-29 Pfizer Inc. Azabicyclo amides and esters as 5-HT3 receptor antagonists

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183565B1 (en) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
FR2514006A1 (en) * 1981-10-05 1983-04-08 Nativelle Sa Ets ACYLAMINO-4 AZA-1 ADAMANTANES, PROCESS FOR THEIR PREPARATION, AND THERAPEUTIC APPLICATION

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803199A (en) * 1982-06-29 1989-02-07 Peter Donatsch Pharmaceutically useful heterocyclic and carbocyclic acid esters and amides of alkylene bridged piperidines
US4910207A (en) * 1982-06-29 1990-03-20 Peter Donatsch Method of treating psychosis with N-quinuclidinyl-benzamides
US5017582A (en) * 1982-06-29 1991-05-21 Sandoz Ltd. Method of inducing a serotonin M receptor antagonist effect with N-quinuclidinyl-benzamides
US4797406A (en) * 1983-08-26 1989-01-10 Sandoz Ltd. Amides and esters containing bridged piperidines and use as serotonin M antagonists
US4593034A (en) * 1984-04-06 1986-06-03 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
US4853376A (en) * 1985-10-19 1989-08-01 Beecham Group, P.L.C. Benzamides and benzoates having anti-emetic activity
WO1991007402A1 (en) * 1989-11-17 1991-05-30 Pfizer Inc. Azabicyclo amides and esters as 5-ht3 receptor antagonists
US5446050A (en) * 1989-11-17 1995-08-29 Pfizer Inc. Azabicyclo amides and esters as 5-HT3 receptor antagonists

Also Published As

Publication number Publication date
AU3156771A (en) 1973-01-25
BE769615A (en) 1971-11-16
FR2100940B1 (en) 1975-06-06
ZA714800B (en) 1972-04-26
CA946402A (en) 1974-04-30
DE2136763A1 (en) 1972-01-27
CH535770A (en) 1973-04-15
IL37340A (en) 1975-12-31
IL37340A0 (en) 1971-12-29
NL7110187A (en) 1972-01-25
AT311375B (en) 1973-11-12
AU464500B2 (en) 1975-08-28
FR2100940A1 (en) 1972-03-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees