GB1269551A - New tricyclic derivatives and process for their manufacture - Google Patents
New tricyclic derivatives and process for their manufactureInfo
- Publication number
- GB1269551A GB1269551A GB1611669A GB1611669A GB1269551A GB 1269551 A GB1269551 A GB 1269551A GB 1611669 A GB1611669 A GB 1611669A GB 1611669 A GB1611669 A GB 1611669A GB 1269551 A GB1269551 A GB 1269551A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- alkyl group
- tricyclic
- resulting
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/16—Eight-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1,269,551. Tricyclic compounds. SCIENCE UNION ET CIE SOC. FRANCAISE DE RECHERCHE MEDICALE. 12 March, 1970 [27 March, 1969], No. 16116/69. Heading C2C. Novel tricyclic compounds of the general formula wherein A is -(CH 2 ) m -, -CH=CH-, -(CH 2 ) p O-, -(CH 2 ) p S-, -(CH 2 ) p SO 2 -, -(CH 2 ) p NR 1 - or -SO 2 NR 2 -, in which m is 1, 2 or 3, p is 1 or 2, R 1 is a hydrogen atom or a C 1-5 alkyl group and R 2 is a C 1-5 alkyl group, X and Y are each a hydrogen or halogen atom, R and R<SP>1</SP> are each a hydrogen atom or a C 1-5 alkyl group and n is an integer from 1 to 12 inclusive, and salts thereof are prepared by condensation of an aminoalkanoic acid ester of the general formula RNH(CH 2 ) n COOR<SP>1</SP>, wherein R<SP>1</SP> is a C 1-5 alkyl group, with a halide of the general formula wherein Hal is a chlorine or bromine atom, and optional saponification of the resulting ester of the first general formula above to give the corresponding free acid, followed optionally by salification of the product with an acid or base. Halides of the third general formula above are prepared by cyclization of a suitable o- (phenyl-A)-benzoic acid, reduction of the resulting tricyclic ketone and halogenation of the resulting hydroxy compound. Pharmaceutical compositions having psychostimulant, antidepressive, analgesic, antitussive, antihistaminic and gastric antisecretory activity comprise, as active ingredient, a tricyclic compound of the first general formula above or a physiologically tolerable salt thereof, together with a pharmaceutically suitable carrier, and may be administered orally, rectally or parenterally.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1611669A GB1269551A (en) | 1969-03-27 | 1969-03-27 | New tricyclic derivatives and process for their manufacture |
NL7003429A NL140526B (en) | 1969-03-27 | 1970-03-11 | PROCESS FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE DIBENZOTHIAZEPINES, PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS AND FORMED PHARMACEUTICAL PREPARATIONS. |
DE19702065635 DE2065635C3 (en) | 1969-03-27 | 1970-03-12 | 10-Dioxo-11-methyldibenzothiazepine derivatives, processes for their production and pharmaceutical preparations containing them |
DE19702011806 DE2011806C3 (en) | 1969-03-27 | 1970-03-12 | Tricyclic compounds, processes for their preparation and pharmaceutical preparations containing them |
DE19702065636 DE2065636C3 (en) | 1969-03-27 | 1970-03-12 | Tricyclic compounds, processes for their preparation and medicaments containing them |
FR7009863A FR2037266B1 (en) | 1969-03-27 | 1970-03-19 | |
DK145070A DK133976B (en) | 1969-03-27 | 1970-03-20 | Analogous process for the preparation of tricyclic compounds or the addition salts of these compounds. |
ES377906A ES377906A1 (en) | 1969-03-27 | 1970-03-24 | New tricyclic derivatives and process for their manufacture |
CH454770A CH522595A (en) | 1969-03-27 | 1970-03-25 | Process for the preparation of new tricyclic derivatives |
BE748032D BE748032A (en) | 1969-03-27 | 1970-03-26 | TRICYCLIC DERIVATIVES AND THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS HAVING PSYCHOSTIMULANT, ANTIDEPRESSIVE, ANALGESIC, ANTITUSSIVE, ANTIHISTAMINIC AND GASTRIC ANTISECRETORY PROPERTIES |
SE428970A SE368005B (en) | 1969-03-27 | 1970-03-26 | |
FR7132198A FR2104729B1 (en) | 1969-03-27 | 1971-09-07 | |
FR7132197A FR2104728B1 (en) | 1969-03-27 | 1971-09-07 | |
SE7305057A SE402104B (en) | 1969-03-27 | 1973-04-10 | WAY TO PRODUCE NEW DIBENSOTIAZEPINES AND DIBENSOTIEPINES INTENDED TO BE USED AS A MEDICINE |
NL737314583A NL154507B (en) | 1969-03-27 | 1973-10-24 | Process for the preparation of a pharmaceutical composition comprising a pharmacologically active derivative of a tricyclic fused ring system CONTAINING aminocarboxylate CONTAINS AND THE RESULTING SHAPED PHARMACEUTICAL PREPARATION AND METHOD FOR PRODUCING A RECORDING IN SUCH PREPARATION SUITABLE DERIVATIVE OF A tricyclic fused ring system CONTAINING AMINOCARBONIC ACID. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1611669A GB1269551A (en) | 1969-03-27 | 1969-03-27 | New tricyclic derivatives and process for their manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1269551A true GB1269551A (en) | 1972-04-06 |
Family
ID=10071471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1611669A Expired GB1269551A (en) | 1969-03-27 | 1969-03-27 | New tricyclic derivatives and process for their manufacture |
Country Status (9)
Country | Link |
---|---|
BE (1) | BE748032A (en) |
CH (1) | CH522595A (en) |
DE (3) | DE2065636C3 (en) |
DK (1) | DK133976B (en) |
ES (1) | ES377906A1 (en) |
FR (3) | FR2037266B1 (en) |
GB (1) | GB1269551A (en) |
NL (1) | NL140526B (en) |
SE (2) | SE368005B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683072B1 (en) | 2003-02-04 | 2004-01-27 | Vela Pharmaceuticals, Inc. | Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia |
WO2004087131A1 (en) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Antitussives |
WO2009073154A1 (en) * | 2007-11-28 | 2009-06-11 | Nektar Therapeutics Al, Corporation | Oligomer-tricyclic conjugates |
US8198268B2 (en) | 2008-10-31 | 2012-06-12 | Janssen Biotech, Inc. | Tianeptine sulfate salt forms and methods of making and using the same |
ITMI20111308A1 (en) * | 2011-07-14 | 2013-01-15 | Cosma S P A | METHOD OF PREPARATION OF TIANEPTINA SALE SODICO |
EP2561864A1 (en) | 2011-08-25 | 2013-02-27 | Zaklady Farmaceutyczne Polpharma SA | Coated tablet comprising tianeptine and process for preparation thereof |
WO2013167906A1 (en) | 2012-05-11 | 2013-11-14 | Numedicus Limited | Treatment of respiratory depression |
JP2017507960A (en) * | 2014-03-12 | 2017-03-23 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークThe Trustees Of Columbia University In The City Of New York | A new class of mu-opioid receptor agonists |
WO2017049158A1 (en) | 2015-09-16 | 2017-03-23 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH629667A5 (en) * | 1978-03-28 | 1982-05-14 | Science Union & Cie | PHARMACEUTICAL COMPOSITION ACTING ON GASTROINTESTINAL MOTORITY. |
FR2594827B1 (en) * | 1986-02-21 | 1988-05-20 | Adir | NEW TRICYCLIC DERIVATIVE ACID ((CHLORO-3 METHYL-6 DIOXO-5.5 DIHYDRO-6, 11 DIBENZO (C, F) THIAZEPINE (1,2) YL-11 AMINO) -5 PENTAZOIQUE, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT |
JPH0578292A (en) * | 1991-04-05 | 1993-03-30 | Hokuriku Seiyaku Co Ltd | Tricyclic compound |
FR2716623B1 (en) | 1994-02-25 | 1996-08-23 | Adir | Use of a tricyclic derivative for obtaining medicaments intended for the treatment of mnemo-cognitive disorders. |
US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
FR2807039A1 (en) | 2000-03-31 | 2001-10-05 | Adir | NOVEL PROCESS FOR THE PREPARATION OF 11-AMINO-3-CHLORO-6,11-DIHYDRO-5,5-DIOXO-6-METHYL-DIBENZO [c, f] [1,2] -THIAZEPINE AND APPLICATION TO THE SYNTHESIS OF TIANEPTINE |
WO2010070667A2 (en) * | 2008-11-19 | 2010-06-24 | Biophore India Pharmaceuticals Pvt. Ltd. | Novel process for the preparation of 7-((3-chloro-6-methyl-5,5-dioxo-6,11-dihydrodibenzo(c,f)(1,2) thiazepin-11-yl)amino)heptanoate |
US8355927B2 (en) | 2010-11-05 | 2013-01-15 | Genomind, Llc | Neuropsychiatric test reports |
GB201106520D0 (en) | 2011-04-18 | 2011-06-01 | Numedicus Ltd | Pharmaceutical compounds |
BRPI1104695B1 (en) * | 2011-09-02 | 2020-10-27 | Universidade Federal Do Rio Grande Do Sul | tianeptine derivatives, pharmaceutical compositions, use, and process for their production |
MX354242B (en) | 2011-10-28 | 2018-02-20 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases. |
KR102199871B1 (en) | 2018-12-21 | 2021-01-08 | 주식회사 한서켐 | A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1543035A1 (en) * | 1965-01-06 | 1969-09-25 | Hoffmann La Roche | Process for the preparation of dibenzocycloheptene compounds |
-
1969
- 1969-03-27 GB GB1611669A patent/GB1269551A/en not_active Expired
-
1970
- 1970-03-11 NL NL7003429A patent/NL140526B/en not_active IP Right Cessation
- 1970-03-12 DE DE19702065636 patent/DE2065636C3/en not_active Expired
- 1970-03-12 DE DE19702011806 patent/DE2011806C3/en not_active Expired
- 1970-03-12 DE DE19702065635 patent/DE2065635C3/en not_active Expired
- 1970-03-19 FR FR7009863A patent/FR2037266B1/fr not_active Expired
- 1970-03-20 DK DK145070A patent/DK133976B/en unknown
- 1970-03-24 ES ES377906A patent/ES377906A1/en not_active Expired
- 1970-03-25 CH CH454770A patent/CH522595A/en not_active IP Right Cessation
- 1970-03-26 SE SE428970A patent/SE368005B/xx unknown
- 1970-03-26 BE BE748032D patent/BE748032A/en not_active IP Right Cessation
-
1971
- 1971-09-07 FR FR7132198A patent/FR2104729B1/fr not_active Expired
- 1971-09-07 FR FR7132197A patent/FR2104728B1/fr not_active Expired
-
1973
- 1973-04-10 SE SE7305057A patent/SE402104B/en unknown
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683072B1 (en) | 2003-02-04 | 2004-01-27 | Vela Pharmaceuticals, Inc. | Compositions and methods for treatment of irritable bowel syndrome and nonulcer dyspepsia |
WO2004087131A1 (en) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Antitussives |
US9725431B2 (en) | 2007-11-28 | 2017-08-08 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
WO2009073154A1 (en) * | 2007-11-28 | 2009-06-11 | Nektar Therapeutics Al, Corporation | Oligomer-tricyclic conjugates |
US8569380B2 (en) | 2007-11-28 | 2013-10-29 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
US8198268B2 (en) | 2008-10-31 | 2012-06-12 | Janssen Biotech, Inc. | Tianeptine sulfate salt forms and methods of making and using the same |
ITMI20111308A1 (en) * | 2011-07-14 | 2013-01-15 | Cosma S P A | METHOD OF PREPARATION OF TIANEPTINA SALE SODICO |
EP2561864A1 (en) | 2011-08-25 | 2013-02-27 | Zaklady Farmaceutyczne Polpharma SA | Coated tablet comprising tianeptine and process for preparation thereof |
WO2013167906A1 (en) | 2012-05-11 | 2013-11-14 | Numedicus Limited | Treatment of respiratory depression |
JP2017507960A (en) * | 2014-03-12 | 2017-03-23 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨークThe Trustees Of Columbia University In The City Of New York | A new class of mu-opioid receptor agonists |
EP3116509A4 (en) * | 2014-03-12 | 2017-08-23 | The Trustees of Columbia University in the City of New York | A new class of mu-opioid receptor agonists |
US10183919B2 (en) | 2014-03-12 | 2019-01-22 | The Trustees Of Columbia University In The City Of New York | Class of mu-opioid receptor agonists |
AU2015229258B2 (en) * | 2014-03-12 | 2020-01-30 | The Trustees Of Columbia University In The City Of New York | A new class of Mu-Opioid receptor agonists |
WO2017049158A1 (en) | 2015-09-16 | 2017-03-23 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
EP3349739A4 (en) * | 2015-09-16 | 2019-02-13 | The Trustees of Columbia University in the City of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
US10844027B2 (en) | 2015-09-16 | 2020-11-24 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
AU2016323977B2 (en) * | 2015-09-16 | 2021-02-25 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
AU2016323977B9 (en) * | 2015-09-16 | 2021-03-04 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
Also Published As
Publication number | Publication date |
---|---|
NL140526B (en) | 1973-12-17 |
FR2104728B1 (en) | 1974-05-24 |
DE2065636A1 (en) | 1974-12-19 |
BE748032A (en) | 1970-09-28 |
DE2011806B2 (en) | 1981-01-08 |
ES377906A1 (en) | 1972-06-16 |
CH522595A (en) | 1972-06-30 |
FR2104729B1 (en) | 1974-05-24 |
FR2037266A1 (en) | 1970-12-31 |
DE2065636B2 (en) | 1978-11-16 |
DE2065636C3 (en) | 1979-07-19 |
DE2065635C3 (en) | 1979-10-04 |
FR2104728A1 (en) | 1972-04-21 |
DK133976B (en) | 1976-08-23 |
SE368005B (en) | 1974-06-17 |
DE2011806A1 (en) | 1970-10-15 |
SE402104B (en) | 1978-06-19 |
DE2011806C3 (en) | 1981-12-03 |
NL7003429A (en) | 1970-09-29 |
DE2065635A1 (en) | 1974-09-05 |
FR2104729A1 (en) | 1972-04-21 |
FR2037266B1 (en) | 1974-05-24 |
DK133976C (en) | 1977-03-21 |
DE2065635B2 (en) | 1979-02-08 |
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