GB1115037A - Improvements in or relating to indolylethylamines - Google Patents
Improvements in or relating to indolylethylaminesInfo
- Publication number
- GB1115037A GB1115037A GB11993/65A GB1199365A GB1115037A GB 1115037 A GB1115037 A GB 1115037A GB 11993/65 A GB11993/65 A GB 11993/65A GB 1199365 A GB1199365 A GB 1199365A GB 1115037 A GB1115037 A GB 1115037A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- hydrogen atom
- group
- compounds
- converted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of the general Formula I <FORM:1115037/C2/1> wherein R1 and R2 each represents a hydroxy or alkoxy group, n1 = 1 or 2, n2 = 0 or 1, R3 represents a hydrogen atom or C1- 4 alkyl group and R4 represents a hydrogen atom, a C1- 4 alkyl group or a group of the Formula Ia <FORM:1115037/C2/2> and their acid addition salts are prepared by standard methods, such as reacting a compound of the Formula V <FORM:1115037/C2/3> with a compound of the Formula VI <FORM:1115037/C2/4> in which formulae R11 and R21 have the same meanings as R1 and R2 in Formula I of the desired product or represent one or more etherified or esterified hydroxy groups which, after the reaction, is or are converted into a free hydroxy group or groups by hydrolysis or hydrogenolysis, R41 has the same meaning as R4 in Formula I or represents an aralkyl group which, after the reaction, is replaced by a hydrogen atom by catalytic reduction, and X represents a halogen atom, in which case n3 = 1, or a double-bonded oxygen atom, in which case n3 = 0 and R41 is a hydrogen atom, the intermediately formed Schiff base being converted into the amine of Formula I by reduction, optionally followed by salt formation. The preparation of o-(2-bromoethoxy)-anisole is described. The compounds of the invention have sedative, anticonvulsant, analgesic and hypotensive activity and some of then have adrenolytic activity. They may be administered in the form of pharmaceutical preparations containing them together with a carrier. Reference has been directed by the Comptroller to Specification 942,548.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL6403114A NL6403114A (en) | 1964-03-24 | 1964-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1115037A true GB1115037A (en) | 1968-05-22 |
Family
ID=19789634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11993/65A Expired GB1115037A (en) | 1964-03-24 | 1965-03-24 | Improvements in or relating to indolylethylamines |
Country Status (10)
| Country | Link |
|---|---|
| AT (2) | AT253498B (en) |
| BE (1) | BE661486A (en) |
| BR (1) | BR6568028D0 (en) |
| CH (1) | CH475239A (en) |
| DE (1) | DE1620069A1 (en) |
| ES (1) | ES310830A1 (en) |
| FR (1) | FR4516M (en) |
| GB (1) | GB1115037A (en) |
| NL (1) | NL6403114A (en) |
| SE (1) | SE303504B (en) |
-
1964
- 1964-03-24 NL NL6403114A patent/NL6403114A/xx unknown
-
1965
- 1965-03-22 BE BE661486A patent/BE661486A/xx unknown
- 1965-03-22 ES ES0310830A patent/ES310830A1/en not_active Expired
- 1965-03-22 DE DE19651620069 patent/DE1620069A1/en active Pending
- 1965-03-22 CH CH390765A patent/CH475239A/en not_active IP Right Cessation
- 1965-03-22 AT AT258765A patent/AT253498B/en active
- 1965-03-22 SE SE3668/65A patent/SE303504B/xx unknown
- 1965-03-22 BR BR168028/65A patent/BR6568028D0/en unknown
- 1965-03-22 AT AT363366A patent/AT254860B/en active
- 1965-03-24 GB GB11993/65A patent/GB1115037A/en not_active Expired
- 1965-05-25 FR FR18411A patent/FR4516M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES310830A1 (en) | 1965-12-01 |
| DE1620069A1 (en) | 1970-03-12 |
| SE303504B (en) | 1968-09-02 |
| AT254860B (en) | 1967-06-12 |
| NL6403114A (en) | 1965-09-27 |
| FR4516M (en) | 1966-10-17 |
| BE661486A (en) | 1965-09-22 |
| CH475239A (en) | 1969-07-15 |
| AT253498B (en) | 1967-04-10 |
| BR6568028D0 (en) | 1973-12-26 |
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