GB1062252A - New substituted phenols process for their preparation and pharmaceutical compositions containing them - Google Patents

New substituted phenols process for their preparation and pharmaceutical compositions containing them

Info

Publication number
GB1062252A
GB1062252A GB45036/62A GB4503662A GB1062252A GB 1062252 A GB1062252 A GB 1062252A GB 45036/62 A GB45036/62 A GB 45036/62A GB 4503662 A GB4503662 A GB 4503662A GB 1062252 A GB1062252 A GB 1062252A
Authority
GB
United Kingdom
Prior art keywords
methyl
pinan
radical
compounds
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB45036/62A
Inventor
Jean Maurice Gazave
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAR PHA SOC D ETUDE ET D EXPL
Original Assignee
MAR PHA SOC D ETUDE ET D EXPL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAR PHA SOC D ETUDE ET D EXPL filed Critical MAR PHA SOC D ETUDE ET D EXPL
Priority to GB45036/62A priority Critical patent/GB1062252A/en
Priority to FR953833A priority patent/FR3383M/en
Priority to DE19631184757 priority patent/DE1184757C2/en
Publication of GB1062252A publication Critical patent/GB1062252A/en
Priority to US018005A priority patent/US3878254A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/39—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with a bicyclo ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises phenol substitutes in either the 2- or the 4-position by a pinan-1-yl radical and in at least one other position by a methyl radical, substituents other than pinan-1-yl and methyl being absent; the compounds are made by reacting camphene with an appropriate methyl-substituted phenol, in presence of a Friedel-Crafts catalyst, e.g. SnCl4. Exemplified products have the following structures <FORM:1062252/C2/1>ALSO:Pharmaceutical compositions for treating infections caused by pyogenic microorganisms comprise, besides a carrier, a phenol substituted in either the 2- or the 4-position by a pinan-1-yl radical and in at least one other position by a methyl radical, substituents other than pinan-1-yl and methyl being absent; the compounds may be used in the form of skin ointments, percutaneous ointments, suppositories, capsules, alcoholic solutions, suspensions for atomisation, ear drops, tablets and suspensions for intramuscular or subcutoneous injections. The compounds may be associated with an antispasmodic a B-group vitamin or a lactic ferment. Exemplified substituted phenols have the following structures: <FORM:1062252/A5-A6/1>
GB45036/62A 1962-11-28 1962-11-28 New substituted phenols process for their preparation and pharmaceutical compositions containing them Expired GB1062252A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB45036/62A GB1062252A (en) 1962-11-28 1962-11-28 New substituted phenols process for their preparation and pharmaceutical compositions containing them
FR953833A FR3383M (en) 1962-11-28 1963-11-15 Camphene-phenol derivatives and pharmaceutical compositions containing them.
DE19631184757 DE1184757C2 (en) 1962-11-28 1963-11-27 METHOD FOR PRODUCING REACTION PRODUCTS FROM 3,4-DIMETHYLPHENOL
US018005A US3878254A (en) 1962-11-28 1970-03-11 6-isoformyl-3,4-xylenol and a process for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45036/62A GB1062252A (en) 1962-11-28 1962-11-28 New substituted phenols process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1062252A true GB1062252A (en) 1967-03-22

Family

ID=10435628

Family Applications (1)

Application Number Title Priority Date Filing Date
GB45036/62A Expired GB1062252A (en) 1962-11-28 1962-11-28 New substituted phenols process for their preparation and pharmaceutical compositions containing them

Country Status (3)

Country Link
DE (1) DE1184757C2 (en)
FR (1) FR3383M (en)
GB (1) GB1062252A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593131A (en) * 1980-09-19 1986-06-03 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4835192A (en) * 1980-09-19 1989-05-30 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4933475A (en) * 1980-09-19 1990-06-12 Pfizer, Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2520173C3 (en) * 1975-05-06 1989-08-10 Südzucker AG Mannheim/Ochsenfurt, 6800 Mannheim Process for the preparation of glucopyranosido-1,6-mannitol and its use as a sugar substitute

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD5051A (en) *
CH295065A (en) * 1941-07-28 1953-12-15 Hoechst Ag Process for the production of condensation products.
DE860946C (en) * 1942-11-24 1952-12-29 Lech Chemie Gersthofen Process for the production of fragrances from terpene phenols
DE876241C (en) * 1943-04-07 1953-05-11 Lech Chemie Gersthofen Process for the production of fragrances from terpene phenols
US2606886A (en) * 1948-10-16 1952-08-12 Hercules Powder Co Ltd Process for the preservation of a rubber with a terpene modified phenol
NL84338C (en) * 1953-11-27
GB788747A (en) * 1954-07-16 1958-01-08 American Cyanamid Co New dihydric phenols and resinous products prepared therefrom

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593131A (en) * 1980-09-19 1986-06-03 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4835192A (en) * 1980-09-19 1989-05-30 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4933475A (en) * 1980-09-19 1990-06-12 Pfizer, Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor

Also Published As

Publication number Publication date
DE1184757B (en) 1981-06-04
FR3383M (en) 1965-06-21
DE1184757C2 (en) 1981-06-04

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