GB1047799A - 1,4-benzodiazepine compounds - Google Patents

1,4-benzodiazepine compounds

Info

Publication number
GB1047799A
GB1047799A GB5215664A GB5215664A GB1047799A GB 1047799 A GB1047799 A GB 1047799A GB 5215664 A GB5215664 A GB 5215664A GB 5215664 A GB5215664 A GB 5215664A GB 1047799 A GB1047799 A GB 1047799A
Authority
GB
United Kingdom
Prior art keywords
compounds
benzodiazepine compounds
benzodiazepine
agent
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5215664A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Pharmaceutical Co filed Critical Warner Lambert Pharmaceutical Co
Publication of GB1047799A publication Critical patent/GB1047799A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/22—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Compounds of the general formula <FORM:1047799/C2/1> (wherein R1 represents a C1- 5 alkyl group and R2 represents a halogen atom) are prepared by converting a compound of the formula <FORM:1047799/C2/2> into an alkali metal derivative and reacting the latter with an alkylating agent in the presence of an inert organic solvent. The compounds of the invention are pharmacologically active and, in particular, 7-chloro-2-methylthio-5-phenyl-3H-1, 4-benzodiazepine is an ataroxic agent. Reference has been directed by the Comptroller to Specification 1,016,668
GB5215664A 1962-04-09 1963-04-08 1,4-benzodiazepine compounds Expired GB1047799A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18582762A 1962-04-09 1962-04-09

Publications (1)

Publication Number Publication Date
GB1047799A true GB1047799A (en) 1966-11-09

Family

ID=22682600

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5215664A Expired GB1047799A (en) 1962-04-09 1963-04-08 1,4-benzodiazepine compounds

Country Status (3)

Country Link
DE (2) DE1620708A1 (en)
DK (1) DK105471C (en)
GB (1) GB1047799A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867370A (en) * 1971-10-08 1975-02-18 Hoffmann La Roche 2-LOWER ALKYSULFONYL-1H-1,4-benzodiazepines
US3868363A (en) * 1974-06-05 1975-02-25 Hoffmann La Roche 1H-5-phenyl-1,4-benzodiazepines
US3869448A (en) * 1971-10-08 1975-03-04 Hoffmann La Roche 2-Lower alkylsulfinyl-1H-1,4-benzodiazepines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138773C2 (en) * 1970-08-07 1982-09-23 Scherico Ltd., 6004 Luzern 1- (2,2,2-Trifluoroethyl) -7-chloro-1,3-dihydro-5-phenyl-2 H-1,4-benzodiazepine-2-thiones, processes for their preparation and pharmaceutical preparations containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867370A (en) * 1971-10-08 1975-02-18 Hoffmann La Roche 2-LOWER ALKYSULFONYL-1H-1,4-benzodiazepines
US3869448A (en) * 1971-10-08 1975-03-04 Hoffmann La Roche 2-Lower alkylsulfinyl-1H-1,4-benzodiazepines
US3868363A (en) * 1974-06-05 1975-02-25 Hoffmann La Roche 1H-5-phenyl-1,4-benzodiazepines

Also Published As

Publication number Publication date
DE1620708A1 (en) 1970-06-04
DE1470415A1 (en) 1969-04-10
DK105471C (en) 1966-10-03

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