FR2858556B1 - Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation - Google Patents

Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation

Info

Publication number
FR2858556B1
FR2858556B1 FR0350403A FR0350403A FR2858556B1 FR 2858556 B1 FR2858556 B1 FR 2858556B1 FR 0350403 A FR0350403 A FR 0350403A FR 0350403 A FR0350403 A FR 0350403A FR 2858556 B1 FR2858556 B1 FR 2858556B1
Authority
FR
France
Prior art keywords
pelletized
dispersible
preparing
pharmaceutical composition
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0350403A
Other languages
English (en)
Other versions
FR2858556A1 (fr
Inventor
Jerome Besse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galenix Innovations Sas
PHARMINNOVATION
Original Assignee
Galenix Innovations Sas
PHARMINNOVATION
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0350403A priority Critical patent/FR2858556B1/fr
Application filed by Galenix Innovations Sas, PHARMINNOVATION filed Critical Galenix Innovations Sas
Priority to JP2006522382A priority patent/JP2007501205A/ja
Priority to PCT/FR2004/050376 priority patent/WO2005013957A2/fr
Priority to AU2004262964A priority patent/AU2004262964A1/en
Priority to EP04786374A priority patent/EP1653936A2/fr
Priority to CA002535026A priority patent/CA2535026A1/fr
Priority to US10/567,345 priority patent/US20070218129A1/en
Publication of FR2858556A1 publication Critical patent/FR2858556A1/fr
Application granted granted Critical
Publication of FR2858556B1 publication Critical patent/FR2858556B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0350403A 2003-08-06 2003-08-06 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation Expired - Fee Related FR2858556B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0350403A FR2858556B1 (fr) 2003-08-06 2003-08-06 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
PCT/FR2004/050376 WO2005013957A2 (fr) 2003-08-06 2004-08-05 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
AU2004262964A AU2004262964A1 (en) 2003-08-06 2004-08-05 Solid dispersible and/or orodispersible non-filmy containing at least one type of active substance pharmaceutical composition and method for the preparation thereof
EP04786374A EP1653936A2 (fr) 2003-08-06 2004-08-05 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
JP2006522382A JP2007501205A (ja) 2003-08-06 2004-08-05 少なくともメトホルミン活性成分を含有する非フィルムコーティーング分散性および／または口内分散性固形調合組成物、およびその製造方法
CA002535026A CA2535026A1 (fr) 2003-08-06 2004-08-05 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation
US10/567,345 US20070218129A1 (en) 2003-08-06 2004-08-05 Solid Dispersible and/or Orodispersible Non-Filmy Containing at Least One Type of Active Substance Pharmaceutical Composition and Method for the Preparation Thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0350403A FR2858556B1 (fr) 2003-08-06 2003-08-06 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation

Publications (2)

Publication Number Publication Date
FR2858556A1 FR2858556A1 (fr) 2005-02-11
FR2858556B1 true FR2858556B1 (fr) 2006-03-10

Family

ID=34073131

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0350403A Expired - Fee Related FR2858556B1 (fr) 2003-08-06 2003-08-06 Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation

Country Status (7)

Country Link
US (1) US20070218129A1 (fr)
EP (1) EP1653936A2 (fr)
JP (1) JP2007501205A (fr)
AU (1) AU2004262964A1 (fr)
CA (1) CA2535026A1 (fr)
FR (1) FR2858556B1 (fr)
WO (1) WO2005013957A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006038226A2 (fr) * 2004-10-08 2006-04-13 Rubicon Research Pvt. Ltd. Compositions de metformine fortement compressibles a liberation controlee
ES2343432T3 (es) 2005-04-26 2010-07-30 Dainippon Sumitomo Pharma Co., Ltd. Preparado granular que contiene un compuesto de biguanida.
BRPI0608609A2 (pt) * 2005-05-10 2010-01-19 Novartis Ag processo de extrusço para preparaÇço de composiÇÕes com compostos terapÊuticos fracamente compressÍveis
EP1962827A4 (fr) * 2005-12-16 2011-02-16 Merck Sharp & Dohme Compositions pharmaceutiques contenant des combinaisons d'inhibiteurs de la dipeptidylpeptidase 4 avec de la métformine
FR2898492B1 (fr) 2006-03-15 2008-06-06 Pierre Fabre Medicament Sa Comprimes orodispersibles de domperidone
US20080107787A1 (en) * 2006-11-02 2008-05-08 The Coca-Cola Company Anti-Diabetic Composition with High-Potency Sweetener
WO2011154975A2 (fr) * 2010-06-08 2011-12-15 Cadila Healthcare Limited Compositions pharmaceutiques de metformine
WO2013077825A1 (fr) 2011-11-23 2013-05-30 Mahmut Bilgic Procédé de fabrication d'une préparation comprenant de la metformine
WO2014144661A1 (fr) 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Compny Forme posologique à dispersion rapide de topiramate
WO2014144512A1 (fr) 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Company Forme pharmaceutique à dispersion rapide contenant du lévétiracétam
JP6463333B2 (ja) 2013-03-15 2019-01-30 アプレシア・ファーマスーティカルズ・カンパニー オキシカルバゼピンの急速分散性の剤形
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
WO2015071859A1 (fr) * 2013-11-18 2015-05-21 Ranbaxy Laboratories Limited Composition dispersible orale d'un inhibiteur de dpp-iv
EP3248594A1 (fr) 2016-05-25 2017-11-29 ratiopharm GmbH Comprimé pour multiples applications orales
CN108272762B (zh) * 2018-03-15 2020-01-14 西南大学 香椿老叶总黄酮分散片及其制备方法
CN116018131A (zh) 2020-06-26 2023-04-25 阿普雷奇亚制药有限责任公司 具有内腔的快速口腔分散片剂

Family Cites Families (26)

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DE1216486B (de) * 1964-04-23 1966-05-12 Merck Ag E Verfahren zur Herstellung von Dragees
JPS5438167B2 (fr) * 1974-04-27 1979-11-19
US6288095B1 (en) * 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
US5130333A (en) * 1990-10-19 1992-07-14 E. R. Squibb & Sons, Inc. Method for treating type II diabetes employing a cholesterol lowering drug
GB9109862D0 (en) * 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
US5370878A (en) * 1993-09-30 1994-12-06 Hallmark Pharmaceuticals, Inc. Method for preparing a direct compression granulated acetaminophen composition
AR017512A1 (es) * 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
EP1039890B1 (fr) * 1997-12-08 2004-03-17 Bristol-Myers Squibb Company Sels de metformine et procede
WO1999032092A1 (fr) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Comprimes a dispersion rapide
FR2774591B1 (fr) * 1998-02-12 2000-05-05 Lipha Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie
US6100300A (en) * 1998-04-28 2000-08-08 Bristol-Myers Squibb Company Metformin formulations and method for treating intermittent claudication employing same
JP4606582B2 (ja) * 1998-04-29 2011-01-05 大日本住友製薬株式会社 ビグアナイド系薬物の内服製剤
EP1121103B1 (fr) * 1998-05-18 2006-12-20 Takeda Pharmaceutical Company Limited Comprimes se desintegrant dans la bouche comprenant une benzimidazole
US6117451A (en) * 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
US6274608B1 (en) * 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
MY125516A (en) * 1999-11-16 2006-08-30 Smithkline Beecham Plc Novel composition based on thiazolidinedione and metformin and use
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP2003520226A (ja) * 2000-01-21 2003-07-02 ノバルティス アクチエンゲゼルシャフト ジペプチジルペプチダーゼ−ｉｖ阻害剤および抗糖尿病薬剤を含む組合せ物
US6316029B1 (en) * 2000-05-18 2001-11-13 Flak Pharma International, Ltd. Rapidly disintegrating solid oral dosage form
US6358526B1 (en) * 2000-08-16 2002-03-19 Rexall Sundown Method of making tablets and tablet compositions produced therefrom
IN192750B (fr) * 2000-12-15 2004-05-15 Ranbaxy Lab Ltd
JP4848558B2 (ja) * 2001-05-08 2011-12-28 トーアエイヨー株式会社 塩酸メトホルミン含有速放性錠剤
US7183321B2 (en) * 2001-12-17 2007-02-27 Bristol-Myers Squibb Company Antidiabetic formulation and method
FR2834889B1 (fr) * 2002-01-18 2004-04-02 Roquette Freres Forme pharmaceutique solide orodispersible
AU2003256419A1 (en) * 2002-08-21 2004-03-11 Merck & Co., Inc. Combination therapy using a dual ppar alpha/gamma agonist and an angiotensin ii type i receptor antagonist

Also Published As

Publication number Publication date
JP2007501205A (ja) 2007-01-25
WO2005013957A2 (fr) 2005-02-17
AU2004262964A1 (en) 2005-02-17
CA2535026A1 (fr) 2005-02-17
FR2858556A1 (fr) 2005-02-11
WO2005013957A3 (fr) 2005-05-26
EP1653936A2 (fr) 2006-05-10
US20070218129A1 (en) 2007-09-20

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