FR2831537B1 - NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF - Google Patents

NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF

Info

Publication number
FR2831537B1
FR2831537B1 FR0113868A FR0113868A FR2831537B1 FR 2831537 B1 FR2831537 B1 FR 2831537B1 FR 0113868 A FR0113868 A FR 0113868A FR 0113868 A FR0113868 A FR 0113868A FR 2831537 B1 FR2831537 B1 FR 2831537B1
Authority
FR
France
Prior art keywords
medicaments
preparation
pharmaceutical compositions
benzimidazole derivatives
novel benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0113868A
Other languages
French (fr)
Other versions
FR2831537A1 (en
Inventor
Fabienne Babin
Brun Alain Le
Lazo Laurence Gauzy
Herve Bouchard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0113868A priority Critical patent/FR2831537B1/en
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to AU2002334217A priority patent/AU2002334217B2/en
Priority to JP2003537632A priority patent/JP5039268B2/en
Priority to MXPA04003954A priority patent/MXPA04003954A/en
Priority to CA2465247A priority patent/CA2465247C/en
Priority to IL16157602A priority patent/IL161576A0/en
Priority to EP02801954A priority patent/EP1441725A1/en
Priority to BR0213562-0A priority patent/BR0213562A/en
Priority to PCT/GB2002/004763 priority patent/WO2003035065A1/en
Priority to US10/279,834 priority patent/US6897208B2/en
Priority to HN2002000311A priority patent/HN2002000311A/en
Priority to GT200200219A priority patent/GT200200219A/en
Priority to UY27516A priority patent/UY27516A1/en
Priority to SV2002001369A priority patent/SV2008001369A/en
Priority to PA20028557101A priority patent/PA8557101A1/en
Priority to PE2002001052A priority patent/PE20030612A1/en
Priority to ARP020104061A priority patent/AR037032A1/en
Priority to JO2002108A priority patent/JO2339B1/en
Publication of FR2831537A1 publication Critical patent/FR2831537A1/en
Priority to US11/029,064 priority patent/US8288425B2/en
Application granted granted Critical
Publication of FR2831537B1 publication Critical patent/FR2831537B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0113868A 2001-10-26 2001-10-26 NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF Expired - Fee Related FR2831537B1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (en) 2001-10-26 2001-10-26 NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
MXPA04003954A MXPA04003954A (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors.
JP2003537632A JP5039268B2 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogs and their use as protein kinase inhibitors
CA2465247A CA2465247C (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
IL16157602A IL161576A0 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
EP02801954A EP1441725A1 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
BR0213562-0A BR0213562A (en) 2001-10-26 2002-10-24 Benzimidazoles and analogs and their use as protein kinase inhibitors
PCT/GB2002/004763 WO2003035065A1 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
US10/279,834 US6897208B2 (en) 2001-10-26 2002-10-24 Benzimidazoles
HN2002000311A HN2002000311A (en) 2001-10-26 2002-10-24 BENZOIMIDAZOLES
AU2002334217A AU2002334217B2 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
ARP020104061A AR037032A1 (en) 2001-10-26 2002-10-25 BENZOIMIDAZOLES
UY27516A UY27516A1 (en) 2001-10-26 2002-10-25 BENCIMIDAZOLS
SV2002001369A SV2008001369A (en) 2001-10-26 2002-10-25 BENZIMIDAZOLES
PA20028557101A PA8557101A1 (en) 2001-10-26 2002-10-25 BENZIMIDAZOLES
PE2002001052A PE20030612A1 (en) 2001-10-26 2002-10-25 BENZOIMIDAZOLES
GT200200219A GT200200219A (en) 2001-10-26 2002-10-25 BENCIMIDAZOLS
JO2002108A JO2339B1 (en) 2001-10-26 2002-10-27 Benzimidazoles
US11/029,064 US8288425B2 (en) 2001-10-26 2005-01-04 Benzimidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (en) 2001-10-26 2001-10-26 NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF

Publications (2)

Publication Number Publication Date
FR2831537A1 FR2831537A1 (en) 2003-05-02
FR2831537B1 true FR2831537B1 (en) 2008-02-29

Family

ID=8868756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0113868A Expired - Fee Related FR2831537B1 (en) 2001-10-26 2001-10-26 NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF

Country Status (2)

Country Link
FR (1) FR2831537B1 (en)
GT (1) GT200200219A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854159B1 (en) * 2003-04-25 2008-01-11 Aventis Pharma Sa NOVEL INDOLE DERIVATIVES, THEIR PREPARATION AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS KDR INHIBITORS
FR2857363B1 (en) * 2003-07-10 2007-09-07 Aventis Pharma Sa SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [3,4-C] PYRIDINES COMPOSITIONS CONTAINING SAME AND USE THEREOF
AR045037A1 (en) * 2003-07-10 2005-10-12 Aventis Pharma Sa TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
JP5753844B2 (en) 2009-07-08 2015-07-22 ダーミラ（カナダ），インコーポレーテッド TOFA analogs useful for the treatment of skin diseases or lesions
MY163531A (en) 2009-08-07 2017-09-15 Chugai Pharmaceutical Co Ltd Aminopyrazole derivative
ES2756175T3 (en) 2013-12-27 2020-04-27 Chugai Pharmaceutical Co Ltd Fgfr guardian mutant genes and drugs that target them
JP6762300B2 (en) 2015-06-17 2020-09-30 中外製薬株式会社 Aminopyrazole derivative
EP3296297A1 (en) * 2016-09-15 2018-03-21 Centre National De La Recherche Scientifique Benzimidazol derivatives for treating filovirus infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130029A1 (en) * 1971-06-18 1972-12-21 Bayer Ag Anthelmintic 2-pyrazolyl-benzimidazoles prodn - from 2-hydroxy -benzimidazoles and pyrazoles with phosphorus halides
DE2130030A1 (en) * 1971-06-18 1972-12-21 Bayer Ag Fungicidal and bactericidal agents
BE793501A (en) * 1971-12-31 1973-06-29 Ciba Geigy HETEROCYCLIC COMPOUNDS AND PHYTOPHARMACEUTICAL PRODUCTS WHICH CONTAIN IT
JP4357004B2 (en) * 1997-04-11 2009-11-04 あすか製薬株式会社 Pyrazole derivative and COX inhibitor containing the same
NZ516348A (en) * 1999-06-23 2003-06-30 Aventis Pharma Gmbh Substituted benzimidazole
PE20010306A1 (en) * 1999-07-02 2001-03-29 Agouron Pharma INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM USEFUL FOR THE INHIBITION OF PROTEIN KINASE
YU54202A (en) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation

Also Published As

Publication number Publication date
FR2831537A1 (en) 2003-05-02
GT200200219A (en) 2003-07-11

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Effective date: 20160630