FR2705094B1 - New lupane derivatives, their preparation and the pharmaceutical compositions containing them. - Google Patents

New lupane derivatives, their preparation and the pharmaceutical compositions containing them.

Info

Publication number
FR2705094B1
FR2705094B1 FR9305619A FR9305619A FR2705094B1 FR 2705094 B1 FR2705094 B1 FR 2705094B1 FR 9305619 A FR9305619 A FR 9305619A FR 9305619 A FR9305619 A FR 9305619A FR 2705094 B1 FR2705094 B1 FR 2705094B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
lupane derivatives
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9305619A
Other languages
French (fr)
Other versions
FR2705094A1 (en
Inventor
Dereu Norbert
Evers Michel
Poujade Christele
Soler Francoise
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9305619A priority Critical patent/FR2705094B1/en
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to PCT/FR1994/000532 priority patent/WO1994026695A1/en
Priority to CA002162702A priority patent/CA2162702A1/en
Priority to AU67879/94A priority patent/AU6787994A/en
Priority to JP6525050A priority patent/JPH08509968A/en
Priority to EP94916260A priority patent/EP0698008A1/en
Priority to ZA943201A priority patent/ZA943201B/en
Publication of FR2705094A1 publication Critical patent/FR2705094A1/en
Application granted granted Critical
Publication of FR2705094B1 publication Critical patent/FR2705094B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/90—Ring systems containing bridged rings containing more than four rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR9305619A 1993-05-11 1993-05-11 New lupane derivatives, their preparation and the pharmaceutical compositions containing them. Expired - Lifetime FR2705094B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9305619A FR2705094B1 (en) 1993-05-11 1993-05-11 New lupane derivatives, their preparation and the pharmaceutical compositions containing them.
CA002162702A CA2162702A1 (en) 1993-05-11 1994-05-06 Novel lupane derivatives, their preparation and pharmaceutical compositions containing same
AU67879/94A AU6787994A (en) 1993-05-11 1994-05-06 Novel lupane derivatives, their preparation and pharmaceutical compositions containing same
JP6525050A JPH08509968A (en) 1993-05-11 1994-05-06 Novel lupine derivative, production thereof and pharmaceutical composition containing the same
PCT/FR1994/000532 WO1994026695A1 (en) 1993-05-11 1994-05-06 Novel lupane derivatives, their preparation and pharmaceutical compositions containing same
EP94916260A EP0698008A1 (en) 1993-05-11 1994-05-06 Novel lupane derivatives, their preparation and pharmaceutical compositions containing same
ZA943201A ZA943201B (en) 1993-05-11 1994-05-09 Novel lupane derivatives their preparation and pharmceutical compositions contiaining them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9305619A FR2705094B1 (en) 1993-05-11 1993-05-11 New lupane derivatives, their preparation and the pharmaceutical compositions containing them.

Publications (2)

Publication Number Publication Date
FR2705094A1 FR2705094A1 (en) 1994-11-18
FR2705094B1 true FR2705094B1 (en) 1995-08-04

Family

ID=9446985

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9305619A Expired - Lifetime FR2705094B1 (en) 1993-05-11 1993-05-11 New lupane derivatives, their preparation and the pharmaceutical compositions containing them.

Country Status (7)

Country Link
EP (1) EP0698008A1 (en)
JP (1) JPH08509968A (en)
AU (1) AU6787994A (en)
CA (1) CA2162702A1 (en)
FR (1) FR2705094B1 (en)
WO (1) WO1994026695A1 (en)
ZA (1) ZA943201B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750578A (en) * 1997-02-11 1998-05-12 Regents Of The University Of Minnesota Use of betulin and analogs thereof to treat herpesvirus infection
US6228850B1 (en) 1997-09-30 2001-05-08 Dabur Research Foundation Antiangiogenic activity of betulinic acid and its derivatives
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
EP0943620B1 (en) * 1998-03-18 2005-11-16 Dabur Pharma Ltd. Betulinic acid derivatives for inhibiting cancer growth
US6214814B1 (en) 1998-03-18 2001-04-10 Dabur Research Foundation Use of betulinic acid derivatives for inhibiting cancer growth
US6482857B1 (en) 1998-07-17 2002-11-19 The University Of Texas Southwestern Medical Center Compositions which contain triterpenes for regulating hair growth
US6124362A (en) * 1998-07-17 2000-09-26 The Procter & Gamble Company Method for regulating hair growth
US6369101B1 (en) 1999-02-26 2002-04-09 Regents Of The University Of Minnesota Therapeutic method to treat herpes virus infection
JP2005194192A (en) * 2002-01-11 2005-07-21 Meiji Seika Kaisha Ltd (4-OXOPIPERIDIN-1-YL)BENZOIC ACID DERIVATIVE AND METHOD FOR PRODUCING INTEGRIN alphavbeta3 INHIBITOR USING THE SAME

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01143832A (en) * 1987-12-01 1989-06-06 Toa Nenryo Kogyo Kk Carcinostatic agent

Also Published As

Publication number Publication date
CA2162702A1 (en) 1994-11-24
AU6787994A (en) 1994-12-12
WO1994026695A1 (en) 1994-11-24
FR2705094A1 (en) 1994-11-18
JPH08509968A (en) 1996-10-22
ZA943201B (en) 1995-01-16
EP0698008A1 (en) 1996-02-28

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