FR2678169B1 - Nouvelles compositions pharmaceutiques comprenant une cyclosporine, pour l'administration par voie orale. - Google Patents

Nouvelles compositions pharmaceutiques comprenant une cyclosporine, pour l'administration par voie orale.

Info

Publication number
FR2678169B1
FR2678169B1 FR9207856A FR9207856A FR2678169B1 FR 2678169 B1 FR2678169 B1 FR 2678169B1 FR 9207856 A FR9207856 A FR 9207856A FR 9207856 A FR9207856 A FR 9207856A FR 2678169 B1 FR2678169 B1 FR 2678169B1
Authority
FR
France
Prior art keywords
cyclosporin
pharmaceutical compositions
oral administration
novel pharmaceutical
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9207856A
Other languages
English (en)
Other versions
FR2678169A1 (fr
Inventor
Armin Meinzer
Birgit Hauer
Ulrich Posanski
Jacky Vonderscher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2678169(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2678169A1 publication Critical patent/FR2678169A1/fr
Application granted granted Critical
Publication of FR2678169B1 publication Critical patent/FR2678169B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
FR9207856A 1991-06-27 1992-06-24 Nouvelles compositions pharmaceutiques comprenant une cyclosporine, pour l'administration par voie orale. Expired - Lifetime FR2678169B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113872A GB9113872D0 (en) 1991-06-27 1991-06-27 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
FR2678169A1 FR2678169A1 (fr) 1992-12-31
FR2678169B1 true FR2678169B1 (fr) 1994-08-26

Family

ID=10697415

Family Applications (2)

Application Number Title Priority Date Filing Date
FR9207856A Expired - Lifetime FR2678169B1 (fr) 1991-06-27 1992-06-24 Nouvelles compositions pharmaceutiques comprenant une cyclosporine, pour l'administration par voie orale.
FR9301141A Granted FR2685706A1 (fr) 1991-06-27 1993-02-01 Produit de transesterification de l'huile de mauis avec le glycerol et sa preparation.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR9301141A Granted FR2685706A1 (fr) 1991-06-27 1993-02-01 Produit de transesterification de l'huile de mauis avec le glycerol et sa preparation.

Country Status (38)

Country Link
EP (2) EP0539319B1 (fr)
JP (2) JP2653958B2 (fr)
KR (3) KR0131064B1 (fr)
CN (1) CN1077798C (fr)
AT (1) AT403436B (fr)
AU (1) AU659460B2 (fr)
CA (2) CA2175842C (fr)
CH (2) CH685764A5 (fr)
CY (1) CY1906A (fr)
CZ (1) CZ281790B6 (fr)
DE (3) DE4244930C2 (fr)
DK (2) DK0953630T3 (fr)
EE (1) EE03108B1 (fr)
ES (2) ES2227921T3 (fr)
FI (2) FI109454B (fr)
FR (2) FR2678169B1 (fr)
GB (2) GB9113872D0 (fr)
GR (1) GR3032366T3 (fr)
HK (2) HK57196A (fr)
HU (1) HU216792B (fr)
IE (1) IE73662B1 (fr)
IL (3) IL118546A (fr)
IT (1) IT1254401B (fr)
LU (1) LU88138A1 (fr)
MX (1) MX9203236A (fr)
MY (1) MY109512A (fr)
NO (2) NO303964B1 (fr)
NZ (1) NZ243309A (fr)
PH (1) PH30337A (fr)
PT (2) PT953630E (fr)
RO (2) RO111021B1 (fr)
RU (1) RU2143919C1 (fr)
SA (1) SA92130213B1 (fr)
SK (1) SK278759B6 (fr)
TW (1) TW267943B (fr)
UA (1) UA35559C2 (fr)
UY (1) UY23864A1 (fr)
ZA (1) ZA924719B (fr)

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EP0589843B1 (fr) * 1992-09-25 2001-11-28 Novartis AG Compositions pharmaceutiques comprenant de la cyclosporine
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
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AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
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DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
US5891846A (en) * 1994-02-17 1999-04-06 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
WO1995022343A1 (fr) * 1994-02-17 1995-08-24 Shiseido Company, Ltd. Composition d'emulsion a base de cyclosporine
NZ270145A (en) * 1994-03-01 1996-08-27 Lilly Co Eli Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
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US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
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KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
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GB0504950D0 (en) 2005-03-10 2005-04-20 Novartis Ag Organic compositions
JP4889262B2 (ja) * 2005-08-19 2012-03-07 理研ビタミン株式会社 脂溶性薬剤組成物
MD3347G2 (ro) * 2006-12-26 2008-01-31 Институт Сельскохозяйственной Техники "Mecagro" Procedeu de obţinere a esterilor metilici din ulei de rapiţă
ITPD20070049A1 (it) * 2007-02-14 2008-08-15 Sila S R L Prodotto a base di acido linoleico coniugato e processo per la sua fabbricazione
CN103120653B (zh) 2007-04-04 2015-09-30 希格默伊德药业有限公司 一种口服药物组合物
CN101199836B (zh) * 2007-11-07 2011-03-30 安徽省药物研究所 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法
SG176145A1 (en) 2009-05-18 2011-12-29 Sigmoid Pharma Ltd Composition comprising oil drops
JP5911799B2 (ja) 2009-08-12 2016-04-27 シグモイド・ファーマ・リミテッドＳｉｇｍｏｉｄ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ ポリマーマトリックスおよび油相を含んで成る免疫調節組成物
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
JO3337B1 (ar) * 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
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PL3215127T3 (pl) 2014-11-07 2021-05-17 Sublimity Therapeutics Limited Kompozycje zawierające cyklosporynę
JPWO2020050182A1 (ja) * 2018-09-06 2020-09-10 株式会社カマタ カプセル充填用液状組成物及びカプセル剤
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Also Published As

Publication number Publication date
FI109454B (fi) 2002-08-15
DK0953630T3 (da) 2004-11-01
FR2685706A1 (fr) 1993-07-02
FI961513A (fi) 1996-04-03
GB2257359B (en) 1996-01-10
IE922082A1 (en) 1992-12-30
ES2142818T3 (es) 2000-05-01
HK157696A (en) 1996-08-30
SK278759B6 (sk) 1998-02-04
CA2175842C (fr) 2002-05-07
EP0539319B1 (fr) 1999-12-08
IT1254401B (it) 1995-09-14
EP0539319A3 (en) 1993-06-09
GB9213393D0 (en) 1992-08-05
CY1906A (en) 1992-06-24
ITRM920476A0 (it) 1992-06-23
GR3032366T3 (en) 2000-04-27
AU659460B2 (en) 1995-05-18
EP0953630A1 (fr) 1999-11-03
IL118546A0 (en) 1996-10-16
KR100231384B1 (en) 1999-11-15
IL102310A (en) 1997-03-18
CN1079907A (zh) 1993-12-29
NO964382L (no) 1992-12-28
FI922958A (fi) 1992-12-28
SK197792A3 (en) 1994-03-09
FR2678169A1 (fr) 1992-12-31
HU9201975D0 (en) 1992-09-28
KR930000113A (ko) 1993-01-15
KR100231385B1 (en) 1999-11-15
DK0539319T3 (da) 2000-05-22
FI116199B (fi) 2005-10-14
CA2072509A1 (fr) 1992-12-28
DE4244986B4 (de) 2008-07-24
CZ281790B6 (cs) 1997-01-15
RU2143919C1 (ru) 2000-01-10
LU88138A1 (fr) 1994-03-01
TW267943B (fr) 1996-01-11
MY109512A (en) 1997-02-28
UA35559C2 (uk) 2001-04-16
HUT62201A (en) 1993-04-28
UY23864A1 (es) 1995-05-29
CA2175842A1 (fr) 1992-12-28
GB2257359A (en) 1993-01-13
DE4219526A1 (de) 1993-03-18
PT953630E (pt) 2004-11-30
HU216792B (hu) 1999-08-30
NO922506D0 (no) 1992-06-25
IE73662B1 (en) 1997-06-18
AT403436B (de) 1998-02-25
IL102310A0 (en) 1993-01-14
AU1852792A (en) 1993-03-11
PH30337A (en) 1997-04-02
FI922958A0 (fi) 1992-06-25
NO303964B1 (no) 1998-10-05
CA2072509C (fr) 1996-07-30
ATA129892A (de) 1997-07-15
JPH05186365A (ja) 1993-07-27
HK57196A (en) 1996-04-12
DE4219526C2 (de) 1999-04-22
FR2685706B1 (fr) 1994-12-23
JP3420897B2 (ja) 2003-06-30
RO111110B1 (ro) 1996-06-28
MX9203236A (es) 1992-12-01
SA92130213B1 (ar) 2004-07-24
CH684163A5 (de) 1994-07-29
CH685764A5 (de) 1995-09-29
ITRM920476A1 (it) 1993-12-23
NO922506L (no) 1992-12-28
EP0539319A2 (fr) 1993-04-28
JP2653958B2 (ja) 1997-09-17
FI961513A0 (fi) 1996-04-03
IL118546A (en) 1998-09-24
NO325267B1 (no) 2008-03-17
ZA924719B (en) 1993-12-27
GB9113872D0 (en) 1991-08-14
NO964382D0 (no) 1996-10-15
CN1077798C (zh) 2002-01-16
JPH09118894A (ja) 1997-05-06
NZ243309A (en) 1995-02-24
RO111021B1 (ro) 1996-06-28
PT539319E (pt) 2000-05-31
EP0953630B1 (fr) 2004-09-08
ES2227921T3 (es) 2005-04-01
EE03108B1 (et) 1998-08-17
KR0131064B1 (ko) 1998-04-17
CZ197792A3 (en) 1993-01-13
DE4244930C2 (de) 1999-11-11

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