FR2645160B1 - - Google Patents

Info

Publication number
FR2645160B1
FR2645160B1 FR8904231A FR8904231A FR2645160B1 FR 2645160 B1 FR2645160 B1 FR 2645160B1 FR 8904231 A FR8904231 A FR 8904231A FR 8904231 A FR8904231 A FR 8904231A FR 2645160 B1 FR2645160 B1 FR 2645160B1
Authority
FR
France
Prior art keywords
magnetisable
crosslinking
water
microspheres
vinylaromatic monomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8904231A
Other languages
French (fr)
Other versions
FR2645160A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhodia Chimie SAS
Original Assignee
Rhone Poulenc Chimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Chimie SA filed Critical Rhone Poulenc Chimie SA
Priority to FR8904231A priority Critical patent/FR2645160B1/fr
Priority to EP90400705A priority patent/EP0390634B1/en
Priority to DE69019411T priority patent/DE69019411T2/en
Priority to ES90400705T priority patent/ES2072996T3/en
Priority to AT90400705T priority patent/ATE122704T1/en
Priority to JP2072259A priority patent/JP2623358B2/en
Priority to IL93947A priority patent/IL93947A0/en
Priority to AU52396/90A priority patent/AU5239690A/en
Priority to NO901440A priority patent/NO178376C/en
Priority to FI901628A priority patent/FI901628A0/en
Priority to CA002013459A priority patent/CA2013459A1/en
Publication of FR2645160A1 publication Critical patent/FR2645160A1/fr
Application granted granted Critical
Publication of FR2645160B1 publication Critical patent/FR2645160B1/fr
Priority to US08/070,053 priority patent/US5356713A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F292/00—Macromolecular compounds obtained by polymerising monomers on to inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K9/00—Use of pretreated ingredients
    • C08K9/10—Encapsulated ingredients
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/64—Magnetic material dispersed in oil drop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/84—Polymer coating, e.g. gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Soft Magnetic Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Polymerisation Methods In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Compounds Of Iron (AREA)
  • Powder Metallurgy (AREA)
  • Hard Magnetic Materials (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)

Abstract

Magnetisable microspheres from 0.05 to 10 mu m in diameter, comprising a core of magnetisable particles and a skin consisting of a hydrophobic crosslinked copolymer derived from a vinylaromatic monomer and from a crosslinking emulsifying polymer. They are obtained by preemulsifying in water a magnetic liquid made up of magnetisable particles dispersed in a vinylaromatic monomer and in a crosslinking emulsifying polymer, polymerisation, separation of the magnetisable microspheres and optional redispersion in water. Use in biology.
FR8904231A 1989-03-31 1989-03-31 Expired - Lifetime FR2645160B1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR8904231A FR2645160B1 (en) 1989-03-31 1989-03-31
EP90400705A EP0390634B1 (en) 1989-03-31 1990-03-16 Hydrophobic, cross-linked, polymeric, magnetisable composite microspheres, method for their preparation and their biological uses
DE69019411T DE69019411T2 (en) 1989-03-31 1990-03-16 Magnetizable microspheres made of cross-linked, hydrophobic polymer, process for their preparation and their use in biology.
ES90400705T ES2072996T3 (en) 1989-03-31 1990-03-16 MAGNETIZABLE COMPOSITE MICROSPHERES OF HYDROPHOBIC RETICULATED POLYMER, ITS PREPARATION PROCEDURE AND ITS APPLICATION IN BIOLOGY.
AT90400705T ATE122704T1 (en) 1989-03-31 1990-03-16 MAGNETIZABLE MICROBLADES MADE OF CROSS-LINKED HYDROPHOBIC POLYMER, METHOD FOR THEIR PRODUCTION AND THEIR USE IN BIOLOGY.
JP2072259A JP2623358B2 (en) 1989-03-31 1990-03-23 Magnetizable composite microspheres of hydrophobic cross-linked polymer, method for its production and its application in biology
IL93947A IL93947A0 (en) 1989-03-31 1990-03-29 Magnetizable composite microspheres
AU52396/90A AU5239690A (en) 1989-03-31 1990-03-29 Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology
NO901440A NO178376C (en) 1989-03-31 1990-03-29 Magnetizable microspheres, their manufacture and use
FI901628A FI901628A0 (en) 1989-03-31 1990-03-30 MAGNETISERBARA KOMPOSITMIKROSFAERER I EN HYDROFOBTVAERBUNDEN POLYMER, DERAS FRAMSTAELLNINGSFOERFARANDE OCH ANPASSANDE I BIOLOGI.
CA002013459A CA2013459A1 (en) 1989-03-31 1990-03-30 Magnetizable composite microspheres of hydrophobic crosslinked polymer, preparation process of same and application in biology
US08/070,053 US5356713A (en) 1989-03-31 1993-06-01 Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8904231A FR2645160B1 (en) 1989-03-31 1989-03-31

Publications (2)

Publication Number Publication Date
FR2645160A1 FR2645160A1 (en) 1990-10-05
FR2645160B1 true FR2645160B1 (en) 1992-10-02

Family

ID=9380242

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8904231A Expired - Lifetime FR2645160B1 (en) 1989-03-31 1989-03-31

Country Status (12)

Country Link
US (1) US5356713A (en)
EP (1) EP0390634B1 (en)
JP (1) JP2623358B2 (en)
AT (1) ATE122704T1 (en)
AU (1) AU5239690A (en)
CA (1) CA2013459A1 (en)
DE (1) DE69019411T2 (en)
ES (1) ES2072996T3 (en)
FI (1) FI901628A0 (en)
FR (1) FR2645160B1 (en)
IL (1) IL93947A0 (en)
NO (1) NO178376C (en)

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US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6663881B2 (en) * 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
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US5628407A (en) * 1994-12-05 1997-05-13 Bolt Beranek And Newman, Inc. Method and apparatus for separation of magnetically responsive spheres
US5684130A (en) * 1995-06-05 1997-11-04 Solid Phase Sciences Corporation Process for synthesis of organic compounds using magnetic particles
JPH11510479A (en) 1995-06-07 1999-09-14 ネオルックス コーポレイション Prevention and treatment of cardiovascular disease with tamoxifen analogs
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Also Published As

Publication number Publication date
EP0390634B1 (en) 1995-05-17
FR2645160A1 (en) 1990-10-05
NO178376C (en) 1996-03-13
AU5239690A (en) 1990-10-04
ES2072996T3 (en) 1995-08-01
NO901440L (en) 1990-10-01
JPH02286729A (en) 1990-11-26
ATE122704T1 (en) 1995-06-15
NO178376B (en) 1995-12-04
DE69019411T2 (en) 1995-11-09
EP0390634A1 (en) 1990-10-03
NO901440D0 (en) 1990-03-29
IL93947A0 (en) 1990-12-23
US5356713A (en) 1994-10-18
DE69019411D1 (en) 1995-06-22
FI901628A0 (en) 1990-03-30
JP2623358B2 (en) 1997-06-25
CA2013459A1 (en) 1990-09-30

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