FR2450837A1 - Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant - Google Patents

Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant

Info

Publication number
FR2450837A1
FR2450837A1 FR8004765A FR8004765A FR2450837A1 FR 2450837 A1 FR2450837 A1 FR 2450837A1 FR 8004765 A FR8004765 A FR 8004765A FR 8004765 A FR8004765 A FR 8004765A FR 2450837 A1 FR2450837 A1 FR 2450837A1
Authority
FR
France
Prior art keywords
pharmaceutical composition
composition containing
production process
lactamase inhibitors
penicillanic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8004765A
Other languages
English (en)
Other versions
FR2450837B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2450837A1 publication Critical patent/FR2450837A1/fr
Application granted granted Critical
Publication of FR2450837B1 publication Critical patent/FR2450837B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE NOTAMMENT DES COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN HALOGENE OU UN RADICAL ORGANIQUE, N EST EGAL A 0, 1 OU 2 ET R EST UN ATOME D'HYDROGENE, UN RESIDU FORMANT UN ESTER HYDROLYSABLE INVIVO OU UN GROUPE PROTEGEANT LA FONCTION CARBOXY DE LA PENICILLINE; LEUR PROCEDE DE PRODUCTION; ET UNE COMPOSITION PHARMACEUTIQUE LES CONTENANT. INHIBITEURS DE B-LACTAMASE.
FR8004765A 1979-03-05 1980-03-04 Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant Granted FR2450837A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1780979A 1979-03-05 1979-03-05
US06/096,832 US4397783A (en) 1979-03-05 1979-11-23 Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners

Publications (2)

Publication Number Publication Date
FR2450837A1 true FR2450837A1 (fr) 1980-10-03
FR2450837B1 FR2450837B1 (fr) 1984-01-13

Family

ID=26690341

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8004765A Granted FR2450837A1 (fr) 1979-03-05 1980-03-04 Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant

Country Status (29)

Country Link
US (1) US4397783A (fr)
KR (1) KR840000589B1 (fr)
AR (1) AR225758A1 (fr)
AT (1) AT369744B (fr)
AU (1) AU518472B2 (fr)
CA (1) CA1154011A (fr)
CH (1) CH648850A5 (fr)
DD (1) DD149366A5 (fr)
DE (1) DE3008316C2 (fr)
DK (1) DK157136C (fr)
ES (1) ES489186A0 (fr)
FI (1) FI71739C (fr)
FR (1) FR2450837A1 (fr)
GB (1) GB2047684B (fr)
GR (1) GR67697B (fr)
HK (1) HK66687A (fr)
IE (1) IE51931B1 (fr)
IL (1) IL59514A (fr)
IT (1) IT1130301B (fr)
KE (1) KE3456A (fr)
LU (1) LU82219A1 (fr)
MY (1) MY8500320A (fr)
NL (1) NL8001286A (fr)
NO (1) NO800617L (fr)
OA (1) OA06496A (fr)
PH (2) PH18550A (fr)
PT (1) PT70898A (fr)
SE (1) SE451329B (fr)
SG (1) SG56484G (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457294A1 (fr) * 1979-05-21 1980-12-19 Rech Applications Therap Derives de l'acide penicillanique utiles comme medicaments, compositions therapeutiques les contenant et procedes de leur preparation
FR2494115A1 (fr) * 1980-11-17 1982-05-21 Rech Applications Therap Preparation pharmaceutique pour le traitement des infections bacteriennes des animaux, contenant un sel ou derive halogeno-6b penicillanique et un ou plusieurs antibiotiques de type b-lactame

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518530A (en) * 1979-03-05 1985-05-21 Pfizer Inc. 6-β-Substituted penicillanic acids as β-lactamase inhibitors
US4511512A (en) * 1980-05-01 1985-04-16 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Produktionsaktiensel skab) Substantially pure dicyclohexyl ammonium 6-β-bromo-penicillanate
EP0139047A1 (fr) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Procédé de préparation de 1,1-dioxyde d'acide 6,6-dibromopénicillanique
GB8522156D0 (en) * 1985-09-06 1985-10-09 Leo Pharm Prod Ltd Producing chemical compounds
ATE77821T1 (de) * 1986-04-10 1992-07-15 Leo Pharm Prod Ltd Verfahren zur herstellung von penicillansaeurederivaten.
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
EP1636240A1 (fr) * 2003-06-05 2006-03-22 Pfizer Products Inc. Promedicament inhibiteur de la beta-lactamase

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2224131A1 (fr) * 1973-04-04 1974-10-31 Massachusetts Inst Technol
FR2361400A1 (fr) * 1976-08-09 1978-03-10 Massachusetts Inst Technology Nouveaux analogues sulfures de penicillines et de cephalosporines, leur procede de preparation et composition pharmaceutique les contenant
US4180506A (en) * 1978-01-18 1979-12-25 Rex Pratt 6β-Bromo penicillanic acid
EP0013662A1 (fr) * 1979-01-10 1980-07-23 Schering Corporation Composés dérivés de 2-pénème, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0013617A1 (fr) * 1979-01-10 1980-07-23 Beecham Group Plc Dérivés de pénicilline, procédé pour leur préparation et compositions pharmaceutiques contenant certains de ces composés

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203992A (en) * 1978-12-11 1980-05-20 E. R. Squibb & Sons, Inc. β-Bromopenicillanic acid sulfone
CA1158639A (fr) * 1978-12-11 1983-12-13 Eric M. Gordon Acide 6-bromopenicillanique sulfone

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2224131A1 (fr) * 1973-04-04 1974-10-31 Massachusetts Inst Technol
FR2361400A1 (fr) * 1976-08-09 1978-03-10 Massachusetts Inst Technology Nouveaux analogues sulfures de penicillines et de cephalosporines, leur procede de preparation et composition pharmaceutique les contenant
US4093625A (en) * 1976-08-09 1978-06-06 Massachusetts Institute Of Technology 6-Sulfur analogs of penicillins and cephalosporins
US4180506A (en) * 1978-01-18 1979-12-25 Rex Pratt 6β-Bromo penicillanic acid
EP0013662A1 (fr) * 1979-01-10 1980-07-23 Schering Corporation Composés dérivés de 2-pénème, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0013617A1 (fr) * 1979-01-10 1980-07-23 Beecham Group Plc Dérivés de pénicilline, procédé pour leur préparation et compositions pharmaceutiques contenant certains de ces composés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/79 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457294A1 (fr) * 1979-05-21 1980-12-19 Rech Applications Therap Derives de l'acide penicillanique utiles comme medicaments, compositions therapeutiques les contenant et procedes de leur preparation
FR2494115A1 (fr) * 1980-11-17 1982-05-21 Rech Applications Therap Preparation pharmaceutique pour le traitement des infections bacteriennes des animaux, contenant un sel ou derive halogeno-6b penicillanique et un ou plusieurs antibiotiques de type b-lactame

Also Published As

Publication number Publication date
KE3456A (en) 1984-10-12
SE451329B (sv) 1987-09-28
ATA118980A (de) 1982-06-15
FI71739C (fi) 1987-02-09
IT1130301B (it) 1986-06-11
US4397783A (en) 1983-08-09
IT8020368A0 (it) 1980-03-05
DK92880A (da) 1980-09-06
AU5610580A (en) 1980-09-18
GB2047684B (en) 1983-09-28
HK66687A (en) 1987-09-25
PT70898A (en) 1980-04-01
KR840000589B1 (ko) 1984-04-24
PH18550A (en) 1985-08-09
CH648850A5 (de) 1985-04-15
ES8103095A1 (es) 1981-02-16
GR67697B (fr) 1981-09-07
MY8500320A (en) 1985-12-31
LU82219A1 (fr) 1980-09-24
AT369744B (de) 1983-01-25
DK157136B (da) 1989-11-13
DE3008316C2 (de) 1982-12-16
GB2047684A (en) 1980-12-03
AR225758A1 (es) 1982-04-30
FI71739B (fi) 1986-10-31
IL59514A0 (en) 1980-06-30
SE8001689L (sv) 1980-09-06
SG56484G (en) 1985-03-08
FI800662A (fi) 1980-09-06
AU518472B2 (en) 1981-10-01
IE800428L (en) 1980-09-05
DD149366A5 (de) 1981-07-08
IE51931B1 (en) 1987-04-29
NL8001286A (nl) 1980-09-09
NO800617L (no) 1980-09-08
IL59514A (en) 1984-01-31
KR830001941A (ko) 1983-05-19
FR2450837B1 (fr) 1984-01-13
DK157136C (da) 1990-04-16
ES489186A0 (es) 1981-02-16
PH17879A (en) 1985-01-14
OA06496A (fr) 1981-07-31
DE3008316A1 (de) 1980-09-25
CA1154011A (fr) 1983-09-20

Similar Documents

Publication Publication Date Title
FR2430410A1 (fr) Phenethanolamines et compositions pharmaceutiques en contenant
NO843836L (no) Terapeutisk aktive sulfamatderivater
FR2405950A1 (fr) Nouveaux 1 oxydes de l'acide penicillanique utiles dans la synthese de medicaments
FR2444031A1 (fr) Nouveaux derives d'imidazole, leur procede de production et composition pharmaceutique les contenant
FR2369297A1 (fr) Nouveaux esters d'acides androstadiene-17-carboxyliques
FR2447904A1 (fr) Nouveau derive d'alcool benzylique, son procede de production et composition pharmaceutique le contenant
FR2391723A1 (fr) Composition therapeutique a base de cetone aliphatique pour le traitement des ulceres peptiques
FR2450837A1 (fr) Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant
JPS5665869A (en) Novel 22hydroxyalkyll3*4*55trihydroxyypiperidine compound* its manufacture and drug
FR2432519A1 (fr) Nouveaux derives de purine et medicament les contenant
GB1477293A (en) Tetralone and indanone derivatives and process for their preparations
SU1318161A3 (ru) Способ получени пиперазиновых производных или их фармацевтически приемлемых солей (его варианты)
FR2395272A1 (fr) Nouveaux medicaments derives de l'acide amidinopenicillanique
FR2368959A1 (fr) Compositions contenant des derives de l'acide guanidinoalcanoique, utilisables comme medicament
FR2392958A1 (fr) Nouveaux amino-acides fluores utiles comme medicament
FR2383931A1 (fr) Derives d'oxadiazolopyrimidine
FR2440353A1 (fr) Nouveaux arylethanols, leurs procedes d'obtention et leur emploi comme medicament
FR2389622A1 (fr)
FR2453152A1 (fr) Nouveaux derives de prostaglandine et medicament les contenant
FI853233L (fi) 1,6-naftyridinderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska produkter.
EA199700287A1 (ru) Бензамиды для лечения нейродегенеративных заболеваний
FR2433522A1 (fr) Nouveau derive de tetrahydrofurannol, son procede de preparation et parfum le contenant
Doyle et al. 532. Antituberculous sulphur compounds. Part II. Some cyclic sulphides derived from dimercaptoalkanols
BG96487A (bg) Р-заместени производни на 4-оксибутанамина,методи за получаването им и тяхното приложение
FR2389631A1 (fr)

Legal Events

Date Code Title Description
ST Notification of lapse