FR2448536A1 - Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation - Google Patents

Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation

Info

Publication number
FR2448536A1
FR2448536A1 FR7907433A FR7907433A FR2448536A1 FR 2448536 A1 FR2448536 A1 FR 2448536A1 FR 7907433 A FR7907433 A FR 7907433A FR 7907433 A FR7907433 A FR 7907433A FR 2448536 A1 FR2448536 A1 FR 2448536A1
Authority
FR
France
Prior art keywords
hydroxymethyl
novel
preparation process
pyrazine derivatives
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7907433A
Other languages
English (en)
Other versions
FR2448536B1 (fr
Inventor
Paolo Cozzi
Osvaldo Magni
Leone Bertone
Romano Angelucci
Pier Paolo Louisolo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2448536A1 publication Critical patent/FR2448536A1/fr
Application granted granted Critical
Publication of FR2448536B1 publication Critical patent/FR2448536B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE: N EST EGAL A 0 OU A 1; R, R ET R PEUVENT ETRE IDENTIQUES OU DIFFERENTS ET REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU D'HALOGENE OU UN GROUPE ALKYLE EN C-C, ALCOXY EN C-C, HYDROXY, MERCAPTO, AMINO OU ACYLAMINO EN C-C; R EST UN ATOME D'HYDROGENE OU UN
FR7907433A 1978-03-23 1979-03-23 Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation Granted FR2448536A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21520/78A IT1094287B (it) 1978-03-23 1978-03-23 Derivati della 2-idrossimetil-pirazina aventi attivita' ipolipemizzante

Publications (2)

Publication Number Publication Date
FR2448536A1 true FR2448536A1 (fr) 1980-09-05
FR2448536B1 FR2448536B1 (fr) 1983-01-28

Family

ID=11183025

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7907433A Granted FR2448536A1 (fr) 1978-03-23 1979-03-23 Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation
FR8004355A Granted FR2445144A1 (fr) 1978-03-23 1980-02-27 A titre de medicaments, derives de 2-hydroxymethyl-pyrazine hypolipemiants et compositions pharmaceutiques les contenant

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8004355A Granted FR2445144A1 (fr) 1978-03-23 1980-02-27 A titre de medicaments, derives de 2-hydroxymethyl-pyrazine hypolipemiants et compositions pharmaceutiques les contenant

Country Status (13)

Country Link
US (1) US4267327A (fr)
JP (1) JPS5531063A (fr)
BE (1) BE875013A (fr)
CA (1) CA1146171A (fr)
CH (1) CH642639A5 (fr)
DE (1) DE2910824A1 (fr)
DK (1) DK151254C (fr)
FR (2) FR2448536A1 (fr)
GB (1) GB2017691B (fr)
IT (1) IT1094287B (fr)
NL (1) NL7902268A (fr)
SE (1) SE446338B (fr)
ZA (1) ZA791047B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406901A (en) * 1980-02-06 1983-09-27 Farmitalia Carlo Erba S.P.A. Ethers of substituted hydroxymethylpyrazines
IL64267A (en) * 1980-12-09 1985-08-30 Erba Farmitalia Ethers of hydroxymethylpyrazin-n-oxides,their preparation and pharmaceutical compositions containing them
JPS59219269A (ja) * 1983-05-30 1984-12-10 Terumo Corp ピラジン誘導体を有効成分とする血小板凝集抑制剤
DE3433960A1 (de) * 1984-09-15 1986-03-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-amino-3-cyano-5-dialkoxymehtyl-pyrazinen und zwischenprodukte fuer diese verfahren
JPS63135216U (fr) * 1987-02-27 1988-09-05
CN101684102B (zh) * 2008-09-28 2013-06-05 安徽省新星药物开发有限责任公司 苯氧乙酸吡嗪酯类衍生物及其制法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051245A (en) * 1972-04-28 1977-09-27 Carlo Erba, S.P.A. Pyrazine 4-oxide derivatives and process for their preparation
US4002750A (en) * 1972-04-28 1977-01-11 Carlo Erba S.P.A. Pyrazine 4-oxide derivatives and process for their preparation
GB1361967A (en) * 1972-04-28 1974-07-30 Erba Carlo Spa Pyrazine 4-oxide derivatives and process for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/48 *
EXBK/71 *

Also Published As

Publication number Publication date
FR2448536B1 (fr) 1983-01-28
JPS6310697B2 (fr) 1988-03-08
BE875013A (fr) 1979-09-24
DK151254B (da) 1987-11-16
GB2017691B (en) 1982-06-16
SE446338B (sv) 1986-09-01
FR2445144B1 (fr) 1983-03-25
CH642639A5 (de) 1984-04-30
DK118879A (da) 1979-09-24
SE7902661L (sv) 1979-09-24
FR2445144A1 (fr) 1980-07-25
CA1146171A (fr) 1983-05-10
IT7821520A0 (it) 1978-03-23
NL7902268A (nl) 1979-09-25
ZA791047B (en) 1980-03-26
IT1094287B (it) 1985-07-26
DE2910824C2 (fr) 1989-06-22
DK151254C (da) 1988-07-04
DE2910824A1 (de) 1979-09-27
GB2017691A (en) 1979-10-10
US4267327A (en) 1981-05-12
JPS5531063A (en) 1980-03-05

Similar Documents

Publication Publication Date Title
FR2384753A1 (fr) Nouveaux thiols et leur procede de preparation
FR2422637A1 (fr) Nouveaux derives de l'acide 2(4-thio-2-oxo-azetidin-1-yl)-3-methylene-butyrique et procede de preparation
FR2603588A1 (fr) Thiazolo (4,5-c) quinoleines, procede de preparation et medicaments les contenant
FR2440950A1 (fr) Nouveaux 4-hydroxy-4h-2,3-dihydrobenzopyranne-4-carboxamides, utiles comme intermediaires chimiques
TNSN87042A1 (fr) Procede de preparation de nouveaux steroides comportant un cycle spirannique en position 17
FR2449682A1 (fr) Derives d'acide quinoleine-carboxylique et leur utilisation en tant qu'agents antimicrobiens
SE7714184L (sv) Piperazinderivat
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
FR2360643A1 (fr) Procede de preparation d'hemi-esters sulfuriques des groupements hydroxy-ethylsulfonyles de colorants organiques
FR2448536A1 (fr) Nouveaux derives de 2-hydroxymethyl-pyrazine, et leur procede de preparation
BE905110A (fr) Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques.
FR2456109A1 (fr) Nouveaux derives a substituants heterocycliques de 7-oximinoacetamido-cephalosporines, utiles notamment comme antibiotiques, et leur procede de preparation
FR2456765A1 (fr) Composes iminoisoindoliniques, leur procede de preparation et leur application comme pigments
FR2452483A1 (fr) Derives d'alcenylphenylmaleimides, leurs dimeres lineaires et leur procede de preparation
FR2438048A1 (fr) Nouveaux derives de 1,3-oxazino (5,6-c) rifamycine doues d'une activite antibiotique
FR2387989A1 (fr) Analogues des alcaloides de l'ergot
FR2449691A1 (fr) Procede de preparation de beta-lactames a proprietes antibiotiques
FR2377367A1 (fr) Procede de preparation d'alcoxy-cetones
FR2411173A1 (fr) Anthranilates de n-hydroxyalkyl-carboxamides et leur application comme reticulants
FR2438036A1 (fr) Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances
FR2371460A1 (fr) Procede de preparation de kanamycine c et de ses derives desoxy
FR2407941A1 (fr) Nouveaux derives de cholesterol
FR2413358A1 (fr) Nouveaux derives de 2-aminomethylphenol, utiles notamment comme agents anti-inflammatoires, et leur procede de preparation
FR2440941A1 (fr) Procede de preparation de derives de n-(phenylcycloalkyl) acetamide, nouveaux produits ainsi obtenus et leur utilisation comme herbicides
FR2419289A1 (fr) Derives de glyoxal-2-oxime et leur procede de preparation

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse