FR2427100A1 - Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid - Google Patents
Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acidInfo
- Publication number
- FR2427100A1 FR2427100A1 FR7816523A FR7816523A FR2427100A1 FR 2427100 A1 FR2427100 A1 FR 2427100A1 FR 7816523 A FR7816523 A FR 7816523A FR 7816523 A FR7816523 A FR 7816523A FR 2427100 A1 FR2427100 A1 FR 2427100A1
- Authority
- FR
- France
- Prior art keywords
- fatty acid
- addn
- prepd
- converting
- highly soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The solubility and stability of basic pharmaceuticals (I) in mixts. of mono- an di-glycerides of 6-12C fatty acids are improved by adding to (I) free 6-18C (6-10C) fatty acids. The resulting salts are then dissolved in the glyceride mixt. Better resorption of (I) from the gastro-intestinal tract. The fatty acid salts of (I) are more soluble in the glyceride mixt. than free bases or hydrochlorides.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7806048A NL7806048A (en) | 1978-06-02 | 1978-06-02 | MEDICINAL PRODUCT WITH BETTER RESORPTION PROPERTIES AND METHOD OF PREPARATION. |
FR7816523A FR2427100A1 (en) | 1978-06-02 | 1978-06-02 | Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7816523A FR2427100A1 (en) | 1978-06-02 | 1978-06-02 | Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2427100A1 true FR2427100A1 (en) | 1979-12-28 |
FR2427100B1 FR2427100B1 (en) | 1981-07-31 |
Family
ID=9208998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7816523A Granted FR2427100A1 (en) | 1978-06-02 | 1978-06-02 | Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2427100A1 (en) |
NL (1) | NL7806048A (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0127426A1 (en) * | 1983-05-23 | 1984-12-05 | Takeda Chemical Industries, Ltd. | Percutaneous pharmaceutical compositions for external use |
EP0152896A3 (en) * | 1984-02-22 | 1986-01-22 | F. Hoffmann-La Roche Ag | Suppositories containing ceftriaxone |
FR2569112A1 (en) * | 1984-08-14 | 1986-02-21 | Israel Inst Biolog Res | TRANSCUTANEOUS DRUG DELIVERY SYSTEM |
EP0177342A2 (en) * | 1984-10-04 | 1986-04-09 | Genentech, Inc. | Oral formulation of therapeutic proteins |
WO1986005694A1 (en) * | 1985-04-02 | 1986-10-09 | Yesair David W | Composition for delivery of orally administered substances |
US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
WO1990012583A1 (en) * | 1989-04-20 | 1990-11-01 | Cortecs Limited | Pharmaceutical compositions |
US5314921A (en) * | 1990-08-13 | 1994-05-24 | Yesair David W | Mixed lipid-bicarbonate colloidal particles |
US5571517A (en) * | 1990-08-13 | 1996-11-05 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
US5891466A (en) * | 1990-08-13 | 1999-04-06 | Yesair; David W. | Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2051574B (en) * | 1979-05-10 | 1984-01-18 | Kyoto Pharma Ind | Adjuvant for promoting absorption of pharmacologically active substances through the rectum |
GB2281697A (en) * | 1993-09-14 | 1995-03-15 | Euro Celtique Sa | Laxative compositions in capsules |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2206943A1 (en) * | 1972-11-18 | 1974-06-14 | Sumitomo Chemical Co | |
FR2321892A1 (en) * | 1975-08-27 | 1977-03-25 | Akzo Nv | PHARMACEUTICAL PREPARATIONS FOR ORAL ADMINISTRATION CONTAINING NANDROLONE-17B ESTER AND NEW NANDROLONE-17B ESTERS |
DE2631281A1 (en) * | 1976-07-12 | 1978-01-19 | Kali Chemie Pharma Gmbh | Increasing solubility of pharmaceuticals for use in gelatin capsules - by dissolving in fatty acid mono:glyceride and opt. di:glyceride cpds. |
FR2365338A1 (en) * | 1976-07-12 | 1978-04-21 | Kali Chemie Pharma Gmbh | PREPARATIONS WITH A HIGH CAPACITY OF RESORPTION BY ENTERIC ROUTE OF CARDIAC GLYCOSIDES REBUILD WITH DIFFICULTY AND PROCESS FOR MANUFACTURING SUCH PREPARATIONS |
DE2700765A1 (en) * | 1977-01-10 | 1978-07-20 | Kali Chemie Pharma Gmbh | Solid-liquid solns. of medicaments, e.g. G-strophanthin - having improved resorption in the gastrointestinal tract, use a solvent mixture of fatty acids and corresp. glyceride(s) |
DE2700501A1 (en) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Solid-liquid solns. of medicaments, e.g. G-strophanthin - having improved resorption in the gastrointestinal tract, use a solvent mixture of fatty acids and oleic acid mono:glyceride |
DE2700433A1 (en) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Pharmaceutical compsns. with good resorption - comprising solns. of e.g. cardiac glycoside(s), steroid hormones, antibiotics and antiinflammatories in free fatty acids |
-
1978
- 1978-06-02 FR FR7816523A patent/FR2427100A1/en active Granted
- 1978-06-02 NL NL7806048A patent/NL7806048A/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2206943A1 (en) * | 1972-11-18 | 1974-06-14 | Sumitomo Chemical Co | |
FR2321892A1 (en) * | 1975-08-27 | 1977-03-25 | Akzo Nv | PHARMACEUTICAL PREPARATIONS FOR ORAL ADMINISTRATION CONTAINING NANDROLONE-17B ESTER AND NEW NANDROLONE-17B ESTERS |
DE2631281A1 (en) * | 1976-07-12 | 1978-01-19 | Kali Chemie Pharma Gmbh | Increasing solubility of pharmaceuticals for use in gelatin capsules - by dissolving in fatty acid mono:glyceride and opt. di:glyceride cpds. |
FR2365338A1 (en) * | 1976-07-12 | 1978-04-21 | Kali Chemie Pharma Gmbh | PREPARATIONS WITH A HIGH CAPACITY OF RESORPTION BY ENTERIC ROUTE OF CARDIAC GLYCOSIDES REBUILD WITH DIFFICULTY AND PROCESS FOR MANUFACTURING SUCH PREPARATIONS |
DE2700501A1 (en) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Solid-liquid solns. of medicaments, e.g. G-strophanthin - having improved resorption in the gastrointestinal tract, use a solvent mixture of fatty acids and oleic acid mono:glyceride |
DE2700433A1 (en) * | 1977-01-07 | 1978-07-20 | Kali Chemie Pharma Gmbh | Pharmaceutical compsns. with good resorption - comprising solns. of e.g. cardiac glycoside(s), steroid hormones, antibiotics and antiinflammatories in free fatty acids |
DE2700765A1 (en) * | 1977-01-10 | 1978-07-20 | Kali Chemie Pharma Gmbh | Solid-liquid solns. of medicaments, e.g. G-strophanthin - having improved resorption in the gastrointestinal tract, use a solvent mixture of fatty acids and corresp. glyceride(s) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0127426A1 (en) * | 1983-05-23 | 1984-12-05 | Takeda Chemical Industries, Ltd. | Percutaneous pharmaceutical compositions for external use |
EP0152896A3 (en) * | 1984-02-22 | 1986-01-22 | F. Hoffmann-La Roche Ag | Suppositories containing ceftriaxone |
FR2569112A1 (en) * | 1984-08-14 | 1986-02-21 | Israel Inst Biolog Res | TRANSCUTANEOUS DRUG DELIVERY SYSTEM |
DE3528979A1 (en) * | 1984-08-14 | 1986-02-27 | State Of Israel Represented By The Prime Minister's Office Israel Institute For Biological Research, Ness-Ziona | DRUG RELEASE SYSTEM |
EP0177342A3 (en) * | 1984-10-04 | 1987-12-02 | Genentech, Inc. | Oral formulation of therapeutic proteins |
EP0177342A2 (en) * | 1984-10-04 | 1986-04-09 | Genentech, Inc. | Oral formulation of therapeutic proteins |
WO1986005694A1 (en) * | 1985-04-02 | 1986-10-09 | Yesair David W | Composition for delivery of orally administered substances |
US4874795A (en) * | 1985-04-02 | 1989-10-17 | Yesair David W | Composition for delivery of orally administered drugs and other substances |
US5972911A (en) * | 1985-04-02 | 1999-10-26 | Yesair; David W. | Composition for the delivery of orally administered drugs and other substances |
WO1990012583A1 (en) * | 1989-04-20 | 1990-11-01 | Cortecs Limited | Pharmaceutical compositions |
US5314921A (en) * | 1990-08-13 | 1994-05-24 | Yesair David W | Mixed lipid-bicarbonate colloidal particles |
US5571517A (en) * | 1990-08-13 | 1996-11-05 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories |
US5707873A (en) * | 1990-08-13 | 1998-01-13 | Yesair; David W. | Method of accessing mixed lipid transport properties of a drug |
US5741822A (en) * | 1990-08-13 | 1998-04-21 | Yesair; David W. | Mixed lipid-bicarbonate colloidal particles for delivering drugs |
US5891466A (en) * | 1990-08-13 | 1999-04-06 | Yesair; David W. | Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories |
Also Published As
Publication number | Publication date |
---|---|
NL7806048A (en) | 1979-12-04 |
FR2427100B1 (en) | 1981-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |