FR2419935A1 - Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant - Google Patents
Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenantInfo
- Publication number
- FR2419935A1 FR2419935A1 FR7906563A FR7906563A FR2419935A1 FR 2419935 A1 FR2419935 A1 FR 2419935A1 FR 7906563 A FR7906563 A FR 7906563A FR 7906563 A FR7906563 A FR 7906563A FR 2419935 A1 FR2419935 A1 FR 2419935A1
- Authority
- FR
- France
- Prior art keywords
- prostaglandin
- analogues
- pharmaceutical compositions
- compositions containing
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003174 prostaglandin I2 derivatives Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
L'invention concerne de nouveaux analogues de la prostaglandine I2 . Ces composés ont la formule ci-dessous, dans laquelle R**1 = H, alcoyle, aralcoyle, cycloalcoyle substitué ou non, phényle substitue ou non, alcoxycarbonylalcoyle, hydroxy- ou alcoxyalcoyle, ou dialcoylaminoalcoyle, R**2, R**3, R**4 = H ou alcoyle, B = liaison simple ou groupe alcoylène, n = E à 6, et
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3053178A JPS54125653A (en) | 1978-03-18 | 1978-03-18 | Prostaglandin i2 analog, its preparation, and drug composition comprising it as active constituent |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2419935A1 true FR2419935A1 (fr) | 1979-10-12 |
FR2419935B1 FR2419935B1 (fr) | 1981-05-08 |
Family
ID=12306373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7906563A Granted FR2419935A1 (fr) | 1978-03-18 | 1979-03-15 | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant |
Country Status (7)
Country | Link |
---|---|
US (1) | US4234597A (fr) |
JP (1) | JPS54125653A (fr) |
CH (1) | CH637930A5 (fr) |
DE (1) | DE2909361A1 (fr) |
FR (1) | FR2419935A1 (fr) |
GB (1) | GB2016456B (fr) |
IT (1) | IT1111997B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55111465A (en) * | 1979-02-20 | 1980-08-28 | Ono Pharmaceut Co Ltd | Prostaglandin i2 analog and its preparation |
US4294759A (en) * | 1979-11-15 | 1981-10-13 | The Upjohn Company | Structural analogues of 5,6,-dihydro PG1 |
DE3006865A1 (de) * | 1980-02-23 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Hetero-imino-prostacycline |
JPS58164512A (ja) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤 |
JPS6130554A (ja) * | 1984-07-23 | 1986-02-12 | Ono Pharmaceut Co Ltd | プロスタグランジン類似化合物のある特定の立体配置を有する異性体及びそれらを有効成分として含有する治療剤 |
JPS6130519A (ja) * | 1984-07-23 | 1986-02-12 | Dainippon Pharmaceut Co Ltd | 脳神経細胞の酸素欠乏性疾患治療剤 |
US5221689A (en) * | 1984-07-23 | 1993-06-22 | Ono Pharmaceutical Co., Ltd. | Prostaglandin analogues, processes for their preparation and pharmaceutical compositions containing them |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178367A (en) * | 1977-02-21 | 1979-12-11 | Ono Pharmaceutical Co. Ltd. | Prostaglandin I2 analogues |
US4097489A (en) * | 1977-06-17 | 1978-06-27 | The Upjohn Company | 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds |
-
1978
- 1978-03-18 JP JP3053178A patent/JPS54125653A/ja active Granted
-
1979
- 1979-03-09 DE DE19792909361 patent/DE2909361A1/de active Granted
- 1979-03-14 GB GB7908994A patent/GB2016456B/en not_active Expired
- 1979-03-14 US US06/020,339 patent/US4234597A/en not_active Expired - Lifetime
- 1979-03-14 IT IT7920978A patent/IT1111997B/it active
- 1979-03-15 FR FR7906563A patent/FR2419935A1/fr active Granted
- 1979-03-16 CH CH252479A patent/CH637930A5/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS6228788B2 (fr) | 1987-06-23 |
JPS54125653A (en) | 1979-09-29 |
DE2909361A1 (de) | 1979-09-27 |
GB2016456B (en) | 1982-08-25 |
FR2419935B1 (fr) | 1981-05-08 |
IT1111997B (it) | 1986-01-13 |
CH637930A5 (fr) | 1983-08-31 |
DE2909361C2 (fr) | 1988-03-10 |
GB2016456A (en) | 1979-09-26 |
US4234597A (en) | 1980-11-18 |
IT7920978A0 (it) | 1979-03-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |