FR2397408A1 - Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension - Google Patents

Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Info

Publication number
FR2397408A1
FR2397408A1 FR7721447A FR7721447A FR2397408A1 FR 2397408 A1 FR2397408 A1 FR 2397408A1 FR 7721447 A FR7721447 A FR 7721447A FR 7721447 A FR7721447 A FR 7721447A FR 2397408 A1 FR2397408 A1 FR 2397408A1
Authority
FR
France
Prior art keywords
alkyl
negligible
essential
treatment
antihypertensive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721447A
Other languages
French (fr)
Other versions
FR2397408B1 (en
Inventor
Michael Dimsdale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7721447A priority Critical patent/FR2397408A1/en
Priority to DE7878400026T priority patent/DE2860691D1/en
Priority to EP78400026A priority patent/EP0000452B1/en
Priority to IL55104A priority patent/IL55104A/en
Priority to DK783073A priority patent/DK307378A/en
Priority to US05/922,527 priority patent/US4261994A/en
Priority to ZA00783941A priority patent/ZA783941B/en
Priority to PT68267A priority patent/PT68267A/en
Priority to CA307,090A priority patent/CA1130806A/en
Priority to GR56739A priority patent/GR64924B/en
Priority to IT25497/78A priority patent/IT1096906B/en
Priority to NZ187825A priority patent/NZ187825A/en
Priority to AU37909/78A priority patent/AU515506B2/en
Priority to NO782404A priority patent/NO782404L/en
Priority to JP53085017A priority patent/JPS5834473B2/en
Priority to FI782220A priority patent/FI782220A/en
Priority to ES471609A priority patent/ES471609A1/en
Priority to AR272930A priority patent/AR222310A1/en
Priority to AT505378A priority patent/AT362367B/en
Publication of FR2397408A1 publication Critical patent/FR2397408A1/en
Priority to ES478527A priority patent/ES478527A1/en
Priority to US06/034,197 priority patent/US4242352A/en
Application granted granted Critical
Publication of FR2397408B1 publication Critical patent/FR2397408B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Oxadiazole derivs. of formula (I) and their pharmaceutically acceptable acid addn. salts are new (where R1-5 are each H, halogen, or alkyl, or 2 adjacent gps. together with the benzene nucleus may form a naphthalene system, and 2 of R1-5 are not H when R is NH2; R is -NR'R" or -N=CR'3-NR'1R'2; R' is H, dialkylaminoalkyl, hydroxyalkyl, dialkylamino-alkoxycarbonyl, pyridinoalkyl or alkyl; R" is H or alkyl; R'3 is H, alkyl, aryl or aralkyl; R'1 and R'2 are each alkyl, hydroxyalkyl or dialkylamino-alkyl; or -NR'R" or -NR'1R'2 may form a heterocycle opt contg. another heteroatom which may be substd. by alkyl; all alkyl gps. are 1-4C). (I) are antihypertensives, useful in treatment of essential or secondary hypertension, and have negligible sedative activity. Doses are e.g. 4-100 mg p.o/day.
FR7721447A 1977-07-12 1977-07-12 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension Granted FR2397408A1 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR7721447A FR2397408A1 (en) 1977-07-12 1977-07-12 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension
DE7878400026T DE2860691D1 (en) 1977-07-12 1978-06-20 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions
EP78400026A EP0000452B1 (en) 1977-07-12 1978-06-20 1,2,4-oxadiazol derivatives, their preparation and application in pharmaceutical compositions
DK783073A DK307378A (en) 1977-07-12 1978-07-07 PROCEDURE FOR THE PREPARATION OF 1,2,4-OXADIAZOLES
US05/922,527 US4261994A (en) 1977-07-12 1978-07-07 1,2,4-Oxadiazole derivatives, their preparation and pharmaceutical use
IL55104A IL55104A (en) 1977-07-12 1978-07-07 1,2,4-oxadiazole derivatives,their preparation and pharmaceutical compositions containing them
IT25497/78A IT1096906B (en) 1977-07-12 1978-07-10 1,2,4-OXADIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY
PT68267A PT68267A (en) 1977-07-12 1978-07-10 PROCESS FOR PREPARING OXADIAZOLE-1,2,4 DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
CA307,090A CA1130806A (en) 1977-07-12 1978-07-10 1,2,4-oxadiazole derivatives, their preparation and pharmaceutical use
GR56739A GR64924B (en) 1977-07-12 1978-07-10 Method for the preparation of oxadiazole derivatives
ZA00783941A ZA783941B (en) 1977-07-12 1978-07-10 Oxadiazole derivatives
NZ187825A NZ187825A (en) 1977-07-12 1978-07-10 1,2,4-oxadiazole derivatives and pharmaceutical compositions
AU37909/78A AU515506B2 (en) 1977-07-12 1978-07-10 1, 2, 4-oxadiazole derivatives
NO782404A NO782404L (en) 1977-07-12 1978-07-10 PROCEDURE FOR THE PREPARATION OF OXADIAZOLE DERIVATIVES
FI782220A FI782220A (en) 1977-07-12 1978-07-11 OXADIAZOLE-1,2,4-DERIVATIVES FOR THE FRAMEWORK OF MEDICINAL PRODUCTS
ES471609A ES471609A1 (en) 1977-07-12 1978-07-11 1,2,4-Oxadiazol derivatives, their preparation and application in pharmaceutical compositions.
JP53085017A JPS5834473B2 (en) 1977-07-12 1978-07-11 1,2,4↓-oxadiazole derivative
AT505378A AT362367B (en) 1977-07-12 1978-07-12 METHOD FOR PRODUCING NEW 1,2,4-OXADIA DIAZOLE DERIVATIVES AND SALTS OF THESE COMPOUNDS
AR272930A AR222310A1 (en) 1977-07-12 1978-07-12 PROCEDURE FOR PREPARING DERIVATIVES OF 5-BENCIL- (1,2,4) -OXADIAZOLE
ES478527A ES478527A1 (en) 1977-07-12 1979-03-12 1,2,4-Oxadiazol derivatives, their preparation and application in pharmaceutical compositions.
US06/034,197 US4242352A (en) 1977-07-12 1979-04-27 3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7721447A FR2397408A1 (en) 1977-07-12 1977-07-12 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Publications (2)

Publication Number Publication Date
FR2397408A1 true FR2397408A1 (en) 1979-02-09
FR2397408B1 FR2397408B1 (en) 1980-04-04

Family

ID=9193282

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721447A Granted FR2397408A1 (en) 1977-07-12 1977-07-12 Antihypertensive 5-benzyl-1,2,4-oxadiazole derivs. - with negligible sedative activity, for treatment of essential or secondary hypertension

Country Status (2)

Country Link
FR (1) FR2397408A1 (en)
ZA (1) ZA783941B (en)

Also Published As

Publication number Publication date
FR2397408B1 (en) 1980-04-04
ZA783941B (en) 1979-07-25

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