FR2366839A2 - Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers - Google Patents

Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers

Info

Publication number
FR2366839A2
FR2366839A2 FR7630377A FR7630377A FR2366839A2 FR 2366839 A2 FR2366839 A2 FR 2366839A2 FR 7630377 A FR7630377 A FR 7630377A FR 7630377 A FR7630377 A FR 7630377A FR 2366839 A2 FR2366839 A2 FR 2366839A2
Authority
FR
France
Prior art keywords
cyclohepta
pyrido
benzo
tranquillisers
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7630377A
Other languages
French (fr)
Other versions
FR2366839B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Canada Inc
Original Assignee
Ayerst Mckenna and Harrison Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ayerst Mckenna and Harrison Inc filed Critical Ayerst Mckenna and Harrison Inc
Priority to FR7630377A priority Critical patent/FR2366839A2/en
Publication of FR2366839A2 publication Critical patent/FR2366839A2/en
Application granted granted Critical
Publication of FR2366839B2 publication Critical patent/FR2366839B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Benzo 6,7 cyclohepta 1,2,3-de pyrido 2,1-a isoquinoline derivs. of formula (I) and their acid-addn. salts are new. In the formula, R1-5 are each H or lower alkyl, pref. H; L is OH or lower alkanoyloxy; M is benzyl, phenyl substd. by a lower alkyl, lower alkoxy, halogen or trihalomethyl gp., furyl, thienyl or pyridyl. Cpds. (I) are CNS depressants (tranquilizers) with a high ratio of CNS depression to ataxic properties and effects on the autonomic nervous system. A typical cpd. (I) is (6a, 15b-trans)-(5-OH, 15b-H-trans)-5-p-anisyl-1,4,5,6,6a,10,11,15b-octahydro-3H-benzo 6- ,7 cyclohepta 1,2,3-de pyrido 2,1-a isoquinolin-5-ol. In an example, this was prepd. from the corresp. ketone and p-methoxyphenylmagnesium bromide.
FR7630377A 1976-10-08 1976-10-08 Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers Granted FR2366839A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7630377A FR2366839A2 (en) 1976-10-08 1976-10-08 Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7630377A FR2366839A2 (en) 1976-10-08 1976-10-08 Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers

Publications (2)

Publication Number Publication Date
FR2366839A2 true FR2366839A2 (en) 1978-05-05
FR2366839B2 FR2366839B2 (en) 1979-02-16

Family

ID=9178538

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7630377A Granted FR2366839A2 (en) 1976-10-08 1976-10-08 Benzo-cyclohepta-pyrido-isoquinoline derivs. - useful as tranquillisers

Country Status (1)

Country Link
FR (1) FR2366839A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081498A1 (en) * 1970-02-10 1971-12-03 Ayerst Mckenna & Harrison

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081498A1 (en) * 1970-02-10 1971-12-03 Ayerst Mckenna & Harrison

Also Published As

Publication number Publication date
FR2366839B2 (en) 1979-02-16

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