FR2340735A1 - Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament - Google Patents
Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicamentInfo
- Publication number
- FR2340735A1 FR2340735A1 FR7603754A FR7603754A FR2340735A1 FR 2340735 A1 FR2340735 A1 FR 2340735A1 FR 7603754 A FR7603754 A FR 7603754A FR 7603754 A FR7603754 A FR 7603754A FR 2340735 A1 FR2340735 A1 FR 2340735A1
- Authority
- FR
- France
- Prior art keywords
- quinoleine
- preparation
- carboxylic acid
- application
- medicinal product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 229960005038 quinisocaine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7603754A FR2340735A1 (fr) | 1976-02-11 | 1976-02-11 | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
SE7700804A SE441528B (sv) | 1976-02-11 | 1977-01-26 | Sett att framstella nya 3-kinolin-karboxylsyraderivat |
US05/766,487 US4107310A (en) | 1976-02-11 | 1977-02-07 | Quinoline-3-carboxamides |
DD7700197299A DD129552A5 (de) | 1976-02-11 | 1977-02-09 | Verfahren zur herstellung von derivaten der 3-chinolinkarbonsaeure |
CA271,429A CA1089464A (fr) | 1976-02-11 | 1977-02-09 | Procede de preparation de nouveaux derives de l'acide 3-quinoleine carboxylique |
DE19772705446 DE2705446A1 (de) | 1976-02-11 | 1977-02-09 | Neue derivate der 3-chinolincarbonsaeure, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
IE289/77A IE44879B1 (en) | 1976-02-11 | 1977-02-10 | N-heterocyclyl-4-hydroxy-quinoline-3-carboxamides |
IL51413A IL51413A (en) | 1976-02-11 | 1977-02-10 | Derivatives of 3-quinoline carboxylic acid, process for preparing them and pharmaceutical compositions |
ES455804A ES455804A1 (es) | 1976-02-11 | 1977-02-10 | Un procedimiento de preparacion de nuevos derivados del aci-do 3-quinolein- carboxilico. |
JP1313977A JPS52116479A (en) | 1976-02-11 | 1977-02-10 | Novel derivative of 33quinolinecarboxylic acid and method for its preparation and phamaceutical composition thereof |
NL7701398A NL7701398A (nl) | 1976-02-11 | 1977-02-10 | Werkwijze ter bereiding van nieuwe chinoline- carbonzuur-3 derivaten, werkwijze ter vervaar- diging van farmaceutische preparaten hiermede, alsmede de aldus gevormde preparaten. |
DK056077A DK150512C (da) | 1976-02-11 | 1977-02-10 | Analogifremgangsmaade til fremstilling af 3-quino-lincarboxylsyrederivater eller syreadditionssalte deraf |
BE174832A BE851306A (fr) | 1976-02-11 | 1977-02-10 | Nouveaux derives de l'acide 3-quinoleine carboxylique |
SU772450451A SU867299A3 (ru) | 1976-02-11 | 1977-02-10 | Способ получени производных 3-хинолинкарбоновой кислоты или их солей |
LU76742A LU76742A1 (fr) | 1976-02-11 | 1977-02-10 | |
ZA00770787A ZA77787B (en) | 1976-02-11 | 1977-02-10 | New derivatives of 3-quinoline carboxylic acid,process for preparing them and pharmaceutical compositions |
GB5556/77A GB1572482A (en) | 1976-02-11 | 1977-02-10 | N-hetero-cyclyl-4-hydrocy-quinoline-3-carboxamides |
AU22218/77A AU508345B2 (en) | 1976-02-11 | 1977-02-11 | Derivatives of 3-quinoline carboxylic acid |
CH172177A CH620437A5 (fr) | 1976-02-11 | 1977-02-11 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7603754A FR2340735A1 (fr) | 1976-02-11 | 1976-02-11 | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2340735A1 true FR2340735A1 (fr) | 1977-09-09 |
FR2340735B1 FR2340735B1 (fr) | 1978-11-03 |
Family
ID=9168994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7603754A Granted FR2340735A1 (fr) | 1976-02-11 | 1976-02-11 | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
Country Status (19)
Country | Link |
---|---|
US (1) | US4107310A (fr) |
JP (1) | JPS52116479A (fr) |
AU (1) | AU508345B2 (fr) |
BE (1) | BE851306A (fr) |
CA (1) | CA1089464A (fr) |
CH (1) | CH620437A5 (fr) |
DD (1) | DD129552A5 (fr) |
DE (1) | DE2705446A1 (fr) |
DK (1) | DK150512C (fr) |
ES (1) | ES455804A1 (fr) |
FR (1) | FR2340735A1 (fr) |
GB (1) | GB1572482A (fr) |
IE (1) | IE44879B1 (fr) |
IL (1) | IL51413A (fr) |
LU (1) | LU76742A1 (fr) |
NL (1) | NL7701398A (fr) |
SE (1) | SE441528B (fr) |
SU (1) | SU867299A3 (fr) |
ZA (1) | ZA77787B (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012639A2 (fr) * | 1978-12-08 | 1980-06-25 | Roussel-Uclaf | Nouveaux dérivés de l'acide 3-quinoléine carboxylique, leur procédé de préparation, leur application comme médicament et les compositions pharmaceutiques les renfermant |
FR2482596A1 (fr) * | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
FR2507602A1 (fr) * | 1981-06-12 | 1982-12-17 | Roussel Uclaf | Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
EP0067772A1 (fr) * | 1981-06-12 | 1982-12-22 | Roussel-Uclaf | Nouveaux dérivés du N-dihydrothiazolyl 3-quinoléine carboxamide, leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions les renfermant |
FR2509728A1 (fr) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
FR2523130A1 (fr) * | 1982-03-15 | 1983-09-16 | Roussel Uclaf | Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
FR2532939A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
FR2537140A1 (fr) * | 1982-12-07 | 1984-06-08 | Roussel Uclaf | Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant |
FR2537139A2 (fr) * | 1982-03-15 | 1984-06-08 | Roussel Uclaf | Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant |
FR2551437A2 (fr) * | 1982-06-03 | 1985-03-08 | Roussel Uclaf | Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190659A (en) * | 1973-08-27 | 1980-02-26 | Sandoz, Inc. | Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters |
US4273930A (en) * | 1977-06-20 | 1981-06-16 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acid esters |
US4187309A (en) * | 1977-06-20 | 1980-02-05 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4281131A (en) | 1977-06-20 | 1981-07-28 | Sandoz, Inc. | 4-Hydroxy-2-quinolinone-3-carboxylic acids and salts thereof |
US4221797A (en) * | 1978-08-14 | 1980-09-09 | Sandoz, Inc. | Dihydroquinoline-one derivatives |
US4266050A (en) * | 1980-07-02 | 1981-05-05 | American Home Products Corporation | 1,2-Dihydro-4-hydroxy-2-imino-N-substituted-3-quinolinecarboxamide derivatives |
IE52670B1 (en) | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
FR2530633A1 (fr) * | 1982-06-03 | 1984-01-27 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, et les compositions les renfermant |
SE452170B (sv) * | 1983-10-03 | 1987-11-16 | Boliden Ab | Forfarande for utvinning av metall ur koppar och/eller edelmetall innehallande material som innehaller antimon och vismut |
FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
US4602014A (en) * | 1984-07-09 | 1986-07-22 | Ciba-Geigy Corporation | Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators |
JPH0358559A (ja) * | 1989-07-26 | 1991-03-13 | Sekisui Chem Co Ltd | 電話システム |
WO1992004327A1 (fr) * | 1990-09-07 | 1992-03-19 | Schering Corporation | Composes antiviraux et composes antihypertenseurs |
US5175151A (en) * | 1990-09-07 | 1992-12-29 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
US5179093A (en) * | 1991-05-10 | 1993-01-12 | Schering Corporation | Quinoline-diones |
DE4138820A1 (de) * | 1991-11-26 | 1993-05-27 | Basf Ag | Chinolin-3-carbonsaeureamide, deren herstellung und verwendung |
SE9201076L (sv) * | 1992-04-06 | 1993-10-07 | Shimon Slavin | Användningen av gamla läkemedel för behandling av diabetes |
SE9400809D0 (sv) * | 1994-03-10 | 1994-03-10 | Pharmacia Ab | New use of quinoline-3-carboxamide compounds |
SE9400810D0 (sv) * | 1994-03-10 | 1994-03-10 | Pharmacia Ab | New use of Quinoline-3-carboxamide compounds |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
SE0400235D0 (sv) * | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New composition containing quinoline compounds |
US8314124B2 (en) * | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
MX365890B (es) * | 2004-06-24 | 2019-06-19 | Vertex Pharma | Moduladores de transportadores con casete de unión con atp. |
RU2528046C2 (ru) * | 2004-06-24 | 2014-09-10 | Вертекс Фармасьютикалз Инкорпорейтед | Модуляторы транспортеров атф-связывающей кассеты |
US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
WO2006087830A1 (fr) * | 2005-02-18 | 2006-08-24 | Kanebo, Ltd. | Structure de textile tisse sous forme de bande et son procede de fabrication |
UA92761C2 (ru) * | 2005-10-19 | 2010-12-10 | Тева Фармасьютикл Индастриз, Лтд. | Кристаллы лаквинимода натрия и способ их изготовления |
AU2006331614A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of ABC transporters |
RS55940B1 (sr) | 2005-12-28 | 2017-09-29 | Vertex Pharma | Čvrsti oblici n-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksohinolin-3-karboksamida |
AR061348A1 (es) | 2006-06-12 | 2008-08-20 | Teva Pharma | Preparados estables de laquinimod |
WO2008097976A1 (fr) * | 2007-02-09 | 2008-08-14 | Kalypsys, Inc. | Modulateurs hétérocycliques de tgr5 pour le traitement des maladies |
WO2009082471A1 (fr) * | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Préparations de laquinimod stables |
CN102143949A (zh) * | 2008-09-03 | 2011-08-03 | 泰华制药工业有限公司 | 2-羰基-1,2-二氢喹啉免疫功能调节剂 |
SG174410A1 (en) | 2009-03-20 | 2011-11-28 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
MX2012001333A (es) * | 2009-07-30 | 2012-06-01 | Teva Pharma | Tratamiento de la enfermedad de crohn con la laquinimod. |
PL2467372T3 (pl) * | 2009-08-10 | 2017-04-28 | Teva Pharmaceutical Industries Ltd. | Leczenie zaburzeń związanych z BDNF z zastosowaniem lakwinimodu |
KR20160129093A (ko) * | 2010-03-03 | 2016-11-08 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드를 이용한 루푸스 신장염의 치료 |
AU2011223702B2 (en) * | 2010-03-03 | 2016-07-14 | Teva Pharmaceutical Industries Ltd. | Treatment of lupus arthritis using laquinimod |
US8501766B2 (en) * | 2010-03-03 | 2013-08-06 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
CN102267984B (zh) * | 2010-06-04 | 2014-07-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 4-羟基喹啉-3-酰胺衍生物及其制备方法和用途 |
BR112013007850A2 (pt) | 2010-10-14 | 2016-06-07 | Immunahr Ab | 1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr |
US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
EP2537517A1 (fr) * | 2011-06-22 | 2012-12-26 | Active Biotech AB | 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide enrichie au deuterium |
WO2013055907A1 (fr) | 2011-10-12 | 2013-04-18 | Teva Pharmaceutical Industries Ltd. | Traitement de la sclérose en plaques par combinaison de laquinimod et de fingolimod |
EA201491460A1 (ru) | 2012-02-03 | 2015-01-30 | Тева Фармасьютикал Индастриз Лтд. | ПРИМЕНЕНИЕ ЛАХИНИМОДА В ЛЕЧЕНИИ ПАЦИЕНТОВ С БОЛЕЗНЬЮ КРОНА, У КОТОРЫХ НЕ ЭФФЕКТИВНА ТЕРАПИЯ ПЕРВОЙ ЛИНИИ АНТИ-TNFα |
RU2692779C2 (ru) | 2012-02-27 | 2019-06-27 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтическая композиция и ее введения |
TW201400117A (zh) | 2012-06-05 | 2014-01-01 | Teva Pharma | 使用拉喹莫德治療眼發炎疾病 |
KR20150091077A (ko) | 2012-11-07 | 2015-08-07 | 테바 파마슈티컬 인더스트리즈 리미티드 | 라퀴니모드의 아민염 |
TWI631105B (zh) | 2013-01-31 | 2018-08-01 | 維泰克斯製藥公司 | 作爲鈉通道調節劑之喹啉及喹噁啉醯胺 |
WO2014153145A2 (fr) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Cristaux de sodium de laquinimod et procédé amélioré pour leur fabrication |
WO2015168103A1 (fr) | 2014-04-29 | 2015-11-05 | Teva Pharmaceutical Industries Ltd. | Laquinimod pour le traitement de patients atteints de sclérose en plaques récurrente rémittente (sep-rr) chez ayant un degré d'incapacité élevé |
EP3204358B1 (fr) | 2014-10-07 | 2018-09-19 | Vertex Pharmaceuticals Incorporated | Co-cristaux de modulateurs du régulateur de conductance transmembranaire de la mucoviscidose |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL289475A (fr) * | 1962-03-01 | |||
US3749731A (en) * | 1971-07-08 | 1973-07-31 | Warner Lambert Co | 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide |
FR2281761A1 (fr) * | 1974-08-13 | 1976-03-12 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
-
1976
- 1976-02-11 FR FR7603754A patent/FR2340735A1/fr active Granted
-
1977
- 1977-01-26 SE SE7700804A patent/SE441528B/xx not_active IP Right Cessation
- 1977-02-07 US US05/766,487 patent/US4107310A/en not_active Expired - Lifetime
- 1977-02-09 CA CA271,429A patent/CA1089464A/fr not_active Expired
- 1977-02-09 DE DE19772705446 patent/DE2705446A1/de active Granted
- 1977-02-09 DD DD7700197299A patent/DD129552A5/xx not_active IP Right Cessation
- 1977-02-10 DK DK056077A patent/DK150512C/da not_active IP Right Cessation
- 1977-02-10 LU LU76742A patent/LU76742A1/xx unknown
- 1977-02-10 SU SU772450451A patent/SU867299A3/ru active
- 1977-02-10 JP JP1313977A patent/JPS52116479A/ja active Granted
- 1977-02-10 ES ES455804A patent/ES455804A1/es not_active Expired
- 1977-02-10 ZA ZA00770787A patent/ZA77787B/xx unknown
- 1977-02-10 NL NL7701398A patent/NL7701398A/xx not_active Application Discontinuation
- 1977-02-10 IE IE289/77A patent/IE44879B1/en unknown
- 1977-02-10 IL IL51413A patent/IL51413A/xx unknown
- 1977-02-10 BE BE174832A patent/BE851306A/fr not_active IP Right Cessation
- 1977-02-10 GB GB5556/77A patent/GB1572482A/en not_active Expired
- 1977-02-11 CH CH172177A patent/CH620437A5/fr not_active IP Right Cessation
- 1977-02-11 AU AU22218/77A patent/AU508345B2/en not_active Expired
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012639A2 (fr) * | 1978-12-08 | 1980-06-25 | Roussel-Uclaf | Nouveaux dérivés de l'acide 3-quinoléine carboxylique, leur procédé de préparation, leur application comme médicament et les compositions pharmaceutiques les renfermant |
FR2443467A1 (fr) * | 1978-12-08 | 1980-07-04 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
EP0012639A3 (en) * | 1978-12-08 | 1980-11-12 | Roussel-Uclaf | Quinolein-3-carboxylic acid derivatives, process for their preparation, their use in medicines and pharmaceutical compositions containing them |
EP0049555A1 (fr) * | 1978-12-08 | 1982-04-14 | Roussel-Uclaf | Nouveaux dérivés de l'acide 2-trifluorométhyl-4-hydroxy-3-quinoline carboxylique et leur procédé de préparation |
FR2482596A1 (fr) * | 1980-05-19 | 1981-11-20 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament |
EP0040573A2 (fr) * | 1980-05-19 | 1981-11-25 | Roussel-Uclaf | Dérivés de l'acide 4-hydroxy 3-quinoléine carboxylique substitués en 2, leur préparation, leur application comme médicament, les compositions les renfermant et les intermédiaires nouveaux obtenus |
EP0040573A3 (en) * | 1980-05-19 | 1982-01-13 | Roussel-Uclaf | 2-substituted-4-hydroxy-3-quinolinecarboxylic acids, their preparation, their use as medicaments, compositions containing them and intermediates |
EP0143123A2 (fr) | 1980-05-19 | 1985-06-05 | Roussel-Uclaf | Produits industriels nouveaux utilisés notamment comme intermédiaires dans la préparation de nouveaux dérivés du 4-hydroxy 3-quinoléine carboxamide substitués en 2 et la préparation desdits intermédiaires |
EP0067772A1 (fr) * | 1981-06-12 | 1982-12-22 | Roussel-Uclaf | Nouveaux dérivés du N-dihydrothiazolyl 3-quinoléine carboxamide, leurs sels, leur procédé de préparation, leur application à titre de médicaments et les compositions les renfermant |
FR2507602A1 (fr) * | 1981-06-12 | 1982-12-17 | Roussel Uclaf | Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
FR2509728A1 (fr) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
EP0070767A1 (fr) * | 1981-07-17 | 1983-01-26 | Roussel-Uclaf | Nouveaux dérivés de la quinoléine, leurs sels, leur préparation, leur application comme médicaments et les compositions les renfermant |
FR2523130A1 (fr) * | 1982-03-15 | 1983-09-16 | Roussel Uclaf | Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
FR2537139A2 (fr) * | 1982-03-15 | 1984-06-08 | Roussel Uclaf | Nouveau derive de la n-dihydrothiazolyl 3-quinoleine carboxamide, procede de preparation, application a titre de medicament et compositions le renfermant |
FR2551437A2 (fr) * | 1982-06-03 | 1985-03-08 | Roussel Uclaf | Nouveaux derives de l'acide 4-oh 3-quinoleine carboxylique substitues en 2, nouveau procede de preparation, leur application comme medicament et les compositions les renfermant et produits necessaires a leur preparation |
FR2532939A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus |
FR2537140A1 (fr) * | 1982-12-07 | 1984-06-08 | Roussel Uclaf | Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant |
Also Published As
Publication number | Publication date |
---|---|
DK150512C (da) | 1987-11-16 |
DE2705446A1 (de) | 1977-08-18 |
BE851306A (fr) | 1977-08-10 |
ZA77787B (en) | 1978-03-29 |
GB1572482A (en) | 1980-07-30 |
AU508345B2 (en) | 1980-03-20 |
IE44879B1 (en) | 1982-05-05 |
DK56077A (da) | 1977-08-12 |
US4107310A (en) | 1978-08-15 |
IL51413A (en) | 1980-09-16 |
LU76742A1 (fr) | 1977-08-19 |
ES455804A1 (es) | 1978-01-16 |
DD129552A5 (de) | 1978-01-25 |
SE7700804L (sv) | 1977-08-12 |
NL7701398A (nl) | 1977-08-15 |
AU2221877A (en) | 1978-08-17 |
SU867299A3 (ru) | 1981-09-23 |
CH620437A5 (fr) | 1980-11-28 |
FR2340735B1 (fr) | 1978-11-03 |
DE2705446C2 (fr) | 1989-10-12 |
IL51413A0 (en) | 1977-04-29 |
DK150512B (da) | 1987-03-16 |
SE441528B (sv) | 1985-10-14 |
JPS623152B2 (fr) | 1987-01-23 |
CA1089464A (fr) | 1980-11-11 |
JPS52116479A (en) | 1977-09-29 |
IE44879L (en) | 1977-08-11 |
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