FR2324304A2 - Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine - Google Patents

Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine

Info

Publication number
FR2324304A2
FR2324304A2 FR7528939A FR7528939A FR2324304A2 FR 2324304 A2 FR2324304 A2 FR 2324304A2 FR 7528939 A FR7528939 A FR 7528939A FR 7528939 A FR7528939 A FR 7528939A FR 2324304 A2 FR2324304 A2 FR 2324304A2
Authority
FR
France
Prior art keywords
quinoline
hydroxy
thiazolyl
prepd
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7528939A
Other languages
French (fr)
Other versions
FR2324304B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7528939A priority Critical patent/FR2324304A2/en
Publication of FR2324304A2 publication Critical patent/FR2324304A2/en
Application granted granted Critical
Publication of FR2324304B2 publication Critical patent/FR2324304B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New 4-hydroxy quinolines are of formula (I):- In (I) R1 is 8-C, and R3 is 2-thiazolyl; R1 is 7-CF3 and R3 is 2-thiazolyl; R1 is 7-Cl and R3 is 2- thiazolyl; R1 is 8-CF3 and R3 is 2- oxazolyl; or R1 is 8-CF3 and R3 is 2-thiazolyl). A typical cpd. is 4-hydroxy-8-chloro-N-(2-thiazolyl) 3-quinoline carboxamide. This was prepd. by reaction of 7 g. 4-hydroxy-8-chloro-3-quinoline carboxylic acid chloride and 2.9 g. 2-amino thiazole in pyridine at ambient temperature. The yield was 6.5 g., m.pt. >369 degrees C.
FR7528939A 1975-09-22 1975-09-22 Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine Granted FR2324304A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7528939A FR2324304A2 (en) 1975-09-22 1975-09-22 Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7528939A FR2324304A2 (en) 1975-09-22 1975-09-22 Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine

Publications (2)

Publication Number Publication Date
FR2324304A2 true FR2324304A2 (en) 1977-04-15
FR2324304B2 FR2324304B2 (en) 1978-09-01

Family

ID=9160268

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7528939A Granted FR2324304A2 (en) 1975-09-22 1975-09-22 Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine

Country Status (1)

Country Link
FR (1) FR2324304A2 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012639A2 (en) * 1978-12-08 1980-06-25 Roussel-Uclaf Quinolein-3-carboxylic acid derivatives, process for their preparation, their use in medicines and pharmaceutical compositions containing them
FR2507602A1 (en) * 1981-06-12 1982-12-17 Roussel Uclaf N-4,5-di:hydro-2-thiazolyl 4-hydroxy 3-quinoline-carboxamide derivs. - anxiolytics having strong affinity for benzodiazepine receptors, opt. used in association with neuroleptics or antidepressants
EP0067772A1 (en) * 1981-06-12 1982-12-22 Roussel-Uclaf N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them
EP0317991A2 (en) * 1987-11-27 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated 1-Aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments
US7495103B2 (en) 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US9139530B2 (en) 2005-12-28 2015-09-22 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US9751839B2 (en) 2009-03-20 2017-09-05 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US10272046B2 (en) 2012-02-27 2019-04-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10646481B2 (en) 2008-08-13 2020-05-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218896A1 (en) * 1973-02-26 1974-09-20 Allen & Hanburys Ltd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2218896A1 (en) * 1973-02-26 1974-09-20 Allen & Hanburys Ltd

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012639A2 (en) * 1978-12-08 1980-06-25 Roussel-Uclaf Quinolein-3-carboxylic acid derivatives, process for their preparation, their use in medicines and pharmaceutical compositions containing them
EP0012639A3 (en) * 1978-12-08 1980-11-12 Roussel-Uclaf Quinolein-3-carboxylic acid derivatives, process for their preparation, their use in medicines and pharmaceutical compositions containing them
EP0049555A1 (en) * 1978-12-08 1982-04-14 Roussel-Uclaf 2-Trifluoromethyl-4-hydroxy-3 quinoline-carboxylic-acid derivatives and their preparation
FR2507602A1 (en) * 1981-06-12 1982-12-17 Roussel Uclaf N-4,5-di:hydro-2-thiazolyl 4-hydroxy 3-quinoline-carboxamide derivs. - anxiolytics having strong affinity for benzodiazepine receptors, opt. used in association with neuroleptics or antidepressants
EP0067772A1 (en) * 1981-06-12 1982-12-22 Roussel-Uclaf N-dihydrothiazolyl-3-quinoleine carboxyamide derivatives, their salts, their preparation and use as pharmaceutical preparations, and pharmaceutical preparations containing them
EP0317991A2 (en) * 1987-11-27 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated 1-Aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments
EP0317991A3 (en) * 1987-11-27 1990-11-07 Hoechst-Roussel Pharmaceuticals Incorporated 1-aryl-3-quinoline- and 1-aryl-3-isoquinoline-carboxamides, a process for their preparation and their use as medicaments
US8629162B2 (en) 2004-06-24 2014-01-14 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8101767B2 (en) 2004-06-24 2012-01-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8324242B2 (en) 2004-06-24 2012-12-04 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US8614327B2 (en) 2004-06-24 2013-12-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US10662192B2 (en) 2004-06-24 2020-05-26 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8741925B2 (en) 2004-06-24 2014-06-03 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7495103B2 (en) 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US9090619B2 (en) 2004-06-24 2015-07-28 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US9139530B2 (en) 2005-12-28 2015-09-22 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9670163B2 (en) 2005-12-28 2017-06-06 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9931334B2 (en) 2005-12-28 2018-04-03 Vertex Pharmaceuticals Incorporated Solid forms of N[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US11291662B2 (en) 2005-12-28 2022-04-05 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US10537565B2 (en) 2005-12-28 2020-01-21 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US11564916B2 (en) 2008-08-13 2023-01-31 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10646481B2 (en) 2008-08-13 2020-05-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US9751839B2 (en) 2009-03-20 2017-09-05 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US11147770B2 (en) 2012-02-27 2021-10-19 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US10272046B2 (en) 2012-02-27 2019-04-30 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US11752106B2 (en) 2012-02-27 2023-09-12 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Also Published As

Publication number Publication date
FR2324304B2 (en) 1978-09-01

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