FR2302994A1 - 1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates - Google Patents

1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates

Info

Publication number
FR2302994A1
FR2302994A1 FR7507120A FR7507120A FR2302994A1 FR 2302994 A1 FR2302994 A1 FR 2302994A1 FR 7507120 A FR7507120 A FR 7507120A FR 7507120 A FR7507120 A FR 7507120A FR 2302994 A1 FR2302994 A1 FR 2302994A1
Authority
FR
France
Prior art keywords
lactones
aryl
pharmaceutical intermediates
carboxylic acids
cyclopropane carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7507120A
Other languages
French (fr)
Other versions
FR2302994B1 (en
Inventor
Henri Cousse
Gilbert Mouzin
Bernard Bonnaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7507120A priority Critical patent/FR2302994A1/en
Publication of FR2302994A1 publication Critical patent/FR2302994A1/en
Application granted granted Critical
Publication of FR2302994B1 publication Critical patent/FR2302994B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel cyclopropane derivs are of formula (I) Ar is phenyl, naphthyl, biphenylyl, pyridyl, furfuryl, thienyl or pyrrolyl gp- opt. monosubstd. by alkyl alkoxy, halogen, NO2, NH2, OH or PhO. The cpds. and their lactones are useful as pharmaceutical intermediates. A typical cpd. is 1-phenyl-2-hydroxymethyl-cyclopropanecarboxylic acid. In an example, this is prepd. by treating benzyl cyanide with NaNH2, reacting the resulting carbanion with epichlorohydrin and hydrolysing the product with KOH.
FR7507120A 1975-03-06 1975-03-06 1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates Granted FR2302994A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7507120A FR2302994A1 (en) 1975-03-06 1975-03-06 1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7507120A FR2302994A1 (en) 1975-03-06 1975-03-06 1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates

Publications (2)

Publication Number Publication Date
FR2302994A1 true FR2302994A1 (en) 1976-10-01
FR2302994B1 FR2302994B1 (en) 1978-02-03

Family

ID=9152239

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7507120A Granted FR2302994A1 (en) 1975-03-06 1975-03-06 1 Aryl 2 hydroxymethyl cyclopropane carboxylic acids - and lactones, pharmaceutical intermediates

Country Status (1)

Country Link
FR (1) FR2302994A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421875A1 (en) * 1978-01-31 1979-11-02 Roussel Uclaf OPTICALLY ACTIVE SUBSTITUTE BENZYL ALCOHOL AND ITS PREPARATION PROCESS
US4507318A (en) * 1981-06-23 1985-03-26 Pierre Fabre S.A. 1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain
FR2740452A1 (en) * 1995-10-25 1997-04-30 Pf Medicament PROCESS FOR THE MANUFACTURE OF 1-PHENYL-2-OXO-3-OXA-BICYCLO (3: 1: 0) HEXANE
FR2743559A1 (en) * 1996-01-16 1997-07-18 Pf Medicament NOVEL PROCESS FOR THE PREPARATION OF BICYCLIC LACTONS
WO2005123709A1 (en) * 2004-06-16 2005-12-29 Sumitomo Chemical Company, Limited Method for producing 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane
WO2012145234A3 (en) * 2011-04-21 2012-12-13 Emory University Cyclopropyl derivatives and methods of use
JP2015509939A (en) * 2012-02-17 2015-04-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
CN108205043A (en) * 2016-12-19 2018-06-26 成都弘达药业有限公司 A kind of left-handed detection method of the Milnacipran intermediate in relation to substance

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421875A1 (en) * 1978-01-31 1979-11-02 Roussel Uclaf OPTICALLY ACTIVE SUBSTITUTE BENZYL ALCOHOL AND ITS PREPARATION PROCESS
US4507318A (en) * 1981-06-23 1985-03-26 Pierre Fabre S.A. 1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain
FR2740452A1 (en) * 1995-10-25 1997-04-30 Pf Medicament PROCESS FOR THE MANUFACTURE OF 1-PHENYL-2-OXO-3-OXA-BICYCLO (3: 1: 0) HEXANE
WO1997015563A1 (en) * 1995-10-25 1997-05-01 Pierre Fabre Medicament Method for making 1-phenyl-2-oxo-3-oxa-bicyclo (3:1:0) hexane
FR2743559A1 (en) * 1996-01-16 1997-07-18 Pf Medicament NOVEL PROCESS FOR THE PREPARATION OF BICYCLIC LACTONS
WO1997026256A1 (en) * 1996-01-16 1997-07-24 Pierre Fabre Medicament New process for the preparation of bicyclic lactones
WO2005123709A1 (en) * 2004-06-16 2005-12-29 Sumitomo Chemical Company, Limited Method for producing 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane
AU2005254872B2 (en) * 2004-06-16 2011-04-07 Sumitomo Chemical Company, Limited Method for producing 2-oxo-1-phenyl-3-oxabicyclo(3.1.0)hexane
KR101185278B1 (en) 2004-06-16 2012-09-21 스미또모 가가꾸 가부시키가이샤 Method for producing 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane
WO2012145234A3 (en) * 2011-04-21 2012-12-13 Emory University Cyclopropyl derivatives and methods of use
US10207984B2 (en) 2011-04-21 2019-02-19 Emory University Cyclopropyl derivatives and methods of use
JP2015509939A (en) * 2012-02-17 2015-04-02 エーザイ・アール・アンド・ディー・マネジメント株式会社 Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
US9828336B2 (en) 2012-02-17 2017-11-28 Eisai R&D Management Co., Ltd. Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
CN108205043A (en) * 2016-12-19 2018-06-26 成都弘达药业有限公司 A kind of left-handed detection method of the Milnacipran intermediate in relation to substance

Also Published As

Publication number Publication date
FR2302994B1 (en) 1978-02-03

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