FR2266506A1 - Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine - Google Patents

Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine

Info

Publication number
FR2266506A1
FR2266506A1 FR7510222A FR7510222A FR2266506A1 FR 2266506 A1 FR2266506 A1 FR 2266506A1 FR 7510222 A FR7510222 A FR 7510222A FR 7510222 A FR7510222 A FR 7510222A FR 2266506 A1 FR2266506 A1 FR 2266506A1
Authority
FR
France
Prior art keywords
cardio
inflammatory
vascular
halopyridine
alkylpiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7510222A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Christiaens SA
Original Assignee
A Christiaens SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Christiaens SA filed Critical A Christiaens SA
Publication of FR2266506A1 publication Critical patent/FR2266506A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyridine derivs. of general formula (I): in which R1 = -CN, -CONR3R4 or -SO2NR3-R4 at posn. 3 or 5; R3 and R4 are indep. H or alkyl(1-3C), opt.substd. with alkoxy (1-2 C) or methylpiperazinyl; R3+R4+N may form pyrrolidine, piperidine, methylpiperidine, morpholine, methylpiperazine or homopiperidine; R2 = alkylpiperazinyl or hydroxyethylpiperazinyl at posns. 2,4 or 6, and their acid-addn. salts have anti-inflammatory, antipyretic and cardio-vascular activity.
FR7510222A 1974-04-04 1975-04-02 Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine Withdrawn FR2266506A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1509474 1974-04-04

Publications (1)

Publication Number Publication Date
FR2266506A1 true FR2266506A1 (en) 1975-10-31

Family

ID=10052924

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7510222A Withdrawn FR2266506A1 (en) 1974-04-04 1975-04-02 Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine

Country Status (8)

Country Link
JP (1) JPS50140469A (en)
BE (1) BE827326A (en)
CA (1) CA1051888A (en)
DE (1) DE2514334A1 (en)
ES (1) ES436109A1 (en)
FR (1) FR2266506A1 (en)
LU (1) LU72195A1 (en)
NL (1) NL7503975A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994456A (en) * 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
DE19918021C1 (en) * 1999-04-21 2000-06-29 Ruetgers Organics Gmbh Preparation of chlorinated pyridine sulfonic acid chloride derivatives from hydroxypyridine sulfonic acids and phosphorus trichloride/chlorine gas; useful as intermediates for drugs, e.g. torasemide
CN1203059C (en) 2000-03-20 2005-05-25 特瓦制药工业有限公司 Novel processes for preparing torsemide intermediate
WO2005097751A2 (en) * 2004-03-31 2005-10-20 Janssen Pharmaceutica, N.V. Non-imidazole heterocyclic compounds as histamine h3-receptor ligands
WO2005118543A1 (en) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. Kinase inhibitor and use thereof
JP2007031391A (en) * 2005-07-29 2007-02-08 Koei Chem Co Ltd Method for producing alkylaminopyridine carbonitrile
CN101495456B (en) 2006-05-30 2014-03-19 詹森药业有限公司 Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
KR101546712B1 (en) 2007-11-20 2015-08-24 얀센 파마슈티카 엔.브이. Cycloalkyloxy- and heterocycloalky-loxypyridine compounds as modulators of the histamine h3 receptor

Also Published As

Publication number Publication date
BE827326A (en) 1975-09-29
LU72195A1 (en) 1975-08-20
ES436109A1 (en) 1977-01-01
CA1051888A (en) 1979-04-03
NL7503975A (en) 1975-10-07
JPS50140469A (en) 1975-11-11
DE2514334A1 (en) 1975-10-09

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Legal Events

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