FR2097737A5 - Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4- - Google Patents

Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-

Info

Publication number
FR2097737A5
FR2097737A5 FR7111317A FR7111317A FR2097737A5 FR 2097737 A5 FR2097737 A5 FR 2097737A5 FR 7111317 A FR7111317 A FR 7111317A FR 7111317 A FR7111317 A FR 7111317A FR 2097737 A5 FR2097737 A5 FR 2097737A5
Authority
FR
France
Prior art keywords
carboxylic acid
substd
isothiocyanates
virustatic
hydrazide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7111317A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlin Chemie AG
Original Assignee
Berlin Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin Chemie AG filed Critical Berlin Chemie AG
Application granted granted Critical
Publication of FR2097737A5 publication Critical patent/FR2097737A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Cpds. of general formula (I): (where R1 = 4-nitrophenyl, styryl, adamantyl-(1)-, 4-chlorophenoxymethyl, phenyl or carbethoxy; R2 = phenyl, 4-chlorophenyl, cyclohexyl, benzyl, naphthyl-(1)-, naphthyl-(2) or n-butyl); are prepd. by reacting carboxylic acid hydrazide with isothiocyanates or by reacting carboxylic acid chlorides with 4-substd. thiosemicarbazides. In an example, phenylisothiocyanate in ethanol is added dropwise to oxalic acid ethyl ester monohydrazide in ethanol and refluxed to give 88% of 1-carbethoxycarbonyl-4-phenylthiosemicarbazide with virustatic activity.
FR7111317A 1970-07-14 1971-03-31 Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4- Expired FR2097737A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD14880370 1970-07-14

Publications (1)

Publication Number Publication Date
FR2097737A5 true FR2097737A5 (en) 1972-03-03

Family

ID=5482717

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7111317A Expired FR2097737A5 (en) 1970-07-14 1971-03-31 Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-

Country Status (5)

Country Link
CH (2) CH548990A (en)
DE (1) DE2126304C3 (en)
FR (1) FR2097737A5 (en)
HU (2) HU164569B (en)
SU (2) SU687069A1 (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436139A1 (en) * 1978-09-14 1980-04-11 Gulf Oil Corp SUBSTITUTED 1-BENZOYL-3-THIOSEMICARBAZIDES, THEIR OBTAINMENT AND THEIR APPLICATION AS PLANT GROWTH REGULATORS
EP0030789A2 (en) * 1979-12-10 1981-06-24 Gulf Oil Corporation Arylthioureido pyridinecarbamino compounds, a process for their preparation and their use as plant growth regulants
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7001923B2 (en) 2001-07-10 2006-02-21 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7037940B2 (en) 2001-07-10 2006-05-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7385084B2 (en) 2004-06-23 2008-06-10 Synta Pharmaceutical Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
US7652168B2 (en) 2001-07-10 2010-01-26 Synta Pharmaceuticals Corp. Synthesis of taxol enhancers
US7678832B2 (en) 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US7709683B2 (en) 2005-05-16 2010-05-04 Synta Pharmaceuticals Corp. Synthesis of bis(thio-hydrazide amide) salts
US7763658B2 (en) 2003-01-15 2010-07-27 Synta Pharmaceuticals Corp. Treatment for cancers
US7939564B2 (en) 2006-08-31 2011-05-10 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US8017654B2 (en) 2005-04-15 2011-09-13 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
US8148426B2 (en) 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
US9156783B2 (en) 2006-08-21 2015-10-13 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134914A (en) * 1975-08-25 1979-01-16 Eli Lilly And Company 1-Acyl-4-substituted phenyl thiosemicarbazides
WO1989006125A1 (en) * 1987-12-31 1989-07-13 Smithkline Beckman Corporation 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436139A1 (en) * 1978-09-14 1980-04-11 Gulf Oil Corp SUBSTITUTED 1-BENZOYL-3-THIOSEMICARBAZIDES, THEIR OBTAINMENT AND THEIR APPLICATION AS PLANT GROWTH REGULATORS
EP0030789A2 (en) * 1979-12-10 1981-06-24 Gulf Oil Corporation Arylthioureido pyridinecarbamino compounds, a process for their preparation and their use as plant growth regulants
EP0030789A3 (en) * 1979-12-10 1981-11-11 Gulf Oil Corporation Arylthioureido pyridinecarbamino compounds, a process for their preparation and their use as plant growth regulants
US7671092B2 (en) 2001-07-10 2010-03-02 Synta Pharmaceuticals Corp. Paclitaxel enhancer compounds
US9107955B2 (en) 2001-07-10 2015-08-18 Synta Pharmaceuticals Corp. Paclitaxel enhancer compounds
US7037940B2 (en) 2001-07-10 2006-05-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7345094B2 (en) 2001-07-10 2008-03-18 Synta Pharmaceuticals Corp. Paclitaxel enhancer compounds
US7368473B2 (en) 2001-07-10 2008-05-06 Synta Pharmaceuticals Corp. Paclitaxel enhancer compounds
US7750042B2 (en) 2001-07-10 2010-07-06 Synta Pharmaceuticals Corp. Paclitaxel enhancer compound
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7001923B2 (en) 2001-07-10 2006-02-21 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US7652168B2 (en) 2001-07-10 2010-01-26 Synta Pharmaceuticals Corp. Synthesis of taxol enhancers
US7763658B2 (en) 2003-01-15 2010-07-27 Synta Pharmaceuticals Corp. Treatment for cancers
US7579503B2 (en) 2004-06-23 2009-08-25 Synta Pharmaceuticals Corp. BIS (thio-hydrazide amide) salts for treatment of cancers
US8461208B2 (en) 2004-06-23 2013-06-11 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US7385084B2 (en) 2004-06-23 2008-06-10 Synta Pharmaceutical Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US7795313B2 (en) 2004-06-23 2010-09-14 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US8048925B2 (en) 2004-06-23 2011-11-01 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US8148426B2 (en) 2004-11-19 2012-04-03 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
US8017654B2 (en) 2005-04-15 2011-09-13 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
US7709683B2 (en) 2005-05-16 2010-05-04 Synta Pharmaceuticals Corp. Synthesis of bis(thio-hydrazide amide) salts
US7678832B2 (en) 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US8623921B2 (en) 2005-08-16 2014-01-07 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
US9156783B2 (en) 2006-08-21 2015-10-13 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US7939564B2 (en) 2006-08-31 2011-05-10 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)

Also Published As

Publication number Publication date
DE2126304A1 (en) 1972-01-20
HU164569B (en) 1974-03-28
DE2126304C3 (en) 1979-11-15
HU164570B (en) 1974-03-28
SU461095A1 (en) 1975-02-25
CH548990A (en) 1974-05-15
CH547787A (en) 1974-04-11
SU687069A1 (en) 1979-09-25
DE2126304B2 (en) 1979-03-29

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Legal Events

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