FI965019A - Entsyymi-inhibiittoreita - Google Patents

Entsyymi-inhibiittoreita Download PDF

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Publication number
FI965019A
FI965019A FI965019A FI965019A FI965019A FI 965019 A FI965019 A FI 965019A FI 965019 A FI965019 A FI 965019A FI 965019 A FI965019 A FI 965019A FI 965019 A FI965019 A FI 965019A
Authority
FI
Finland
Prior art keywords
enzyme inhibitors
protecting group
amidino
intermediates
chem
Prior art date
Application number
FI965019A
Other languages
English (en)
Swedish (sv)
Other versions
FI965019A0 (fi
Inventor
Harold Francis Hodson
Richard Michael John Palmer
David Alan Sawyer
Richard Graham Knowles
Karl Witold Franzmann
Martin James Drysdale
Steven Smith
Patricia Ifeyinwa Davies
Helen Alice Rebecca Clark
Barry George Shearer
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI965019A0 publication Critical patent/FI965019A0/fi
Publication of FI965019A publication Critical patent/FI965019A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI965019A 1994-06-15 1996-12-13 Entsyymi-inhibiittoreita FI965019A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94304314 1994-06-15
GBGB9509774.7A GB9509774D0 (en) 1995-05-15 1995-05-15 Enzyme inhibitors
PCT/GB1995/001378 WO1995034534A1 (en) 1994-06-15 1995-06-14 Enzyme inhibitors

Publications (2)

Publication Number Publication Date
FI965019A0 FI965019A0 (fi) 1996-12-13
FI965019A true FI965019A (fi) 1996-12-13

Family

ID=26137155

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965019A FI965019A (fi) 1994-06-15 1996-12-13 Entsyymi-inhibiittoreita

Country Status (29)

Country Link
US (2) US5889056A (fi)
EP (2) EP0957087B1 (fi)
JP (2) JP2989010B2 (fi)
KR (1) KR100430207B1 (fi)
CN (1) CN1070849C (fi)
AT (2) ATE229001T1 (fi)
AU (1) AU692892B2 (fi)
BR (1) BR9507995A (fi)
CA (1) CA2192668A1 (fi)
CY (2) CY2238B1 (fi)
DE (2) DE69529101T2 (fi)
DK (2) DK0957087T3 (fi)
ES (2) ES2145282T3 (fi)
FI (1) FI965019A (fi)
GR (1) GR3033746T3 (fi)
HK (1) HK1003935A1 (fi)
HU (1) HUT77407A (fi)
IL (2) IL114142A (fi)
IS (1) IS4384A (fi)
MX (1) MX9606136A (fi)
MY (1) MY115437A (fi)
NO (1) NO308655B1 (fi)
NZ (1) NZ289157A (fi)
PT (2) PT765308E (fi)
RU (1) RU2162841C2 (fi)
SI (2) SI0957087T1 (fi)
TW (1) TW442453B (fi)
WO (1) WO1995034534A1 (fi)
ZA (1) ZA954940B (fi)

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GEP20043179B (en) * 1998-03-11 2004-02-25 Searle & Co Halogenated Amidino Amino Acid Derivatives Useful as Nitric Oxide Synthase Inhibitors
WO1999055679A1 (en) 1998-04-28 1999-11-04 Trega Biosciences, Inc. Isoquinoline compound melanocortin receptor ligands and methods of using same
US6534503B1 (en) 1998-04-28 2003-03-18 Lion Bioscience Ag Melanocortin receptor-3 ligands to treat sexual dysfunction
US6284735B1 (en) * 1998-04-28 2001-09-04 Lion Bioscience Ag HP-3228 and related peptides to treat sexual dysfunction
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
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DE60116067T2 (de) * 2000-03-24 2006-08-31 Pharmacia Corp., Chicago Amidino-verbindungen als hemmstoffe der stickstoffmonoxid-synthase
AR034120A1 (es) * 2000-04-13 2004-02-04 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
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DE10111049A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut
DE10111052A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
DE10111050A1 (de) * 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung
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Also Published As

Publication number Publication date
HK1003935A1 (en) 1998-11-13
NO965379L (no) 1996-12-13
EP0765308B1 (en) 2000-04-05
JP2989010B2 (ja) 1999-12-13
IS4384A (is) 1996-11-13
ATE191470T1 (de) 2000-04-15
AU2891795A (en) 1996-01-05
IL114142A (en) 2000-02-17
NZ289157A (en) 1998-03-25
FI965019A0 (fi) 1996-12-13
EP0957087B1 (en) 2002-12-04
GR3033746T3 (en) 2000-10-31
KR100430207B1 (ko) 2004-07-19
PT765308E (pt) 2000-09-29
MY115437A (en) 2003-06-30
CA2192668A1 (en) 1995-12-21
EP0957087A3 (en) 2000-12-20
TW442453B (en) 2001-06-23
SI0765308T1 (en) 2000-08-31
DE69529101T2 (de) 2003-11-13
ZA954940B (en) 1996-12-17
US5889056A (en) 1999-03-30
ATE229001T1 (de) 2002-12-15
DE69516141T2 (de) 2000-10-19
DK0957087T3 (da) 2003-03-24
ES2189322T3 (es) 2003-07-01
JP3614711B2 (ja) 2005-01-26
CY2455B1 (en) 2005-06-03
MX9606136A (es) 1998-06-30
CY2238B1 (en) 2003-07-04
WO1995034534A1 (en) 1995-12-21
CN1155276A (zh) 1997-07-23
JP2000026402A (ja) 2000-01-25
DE69516141D1 (de) 2000-05-11
DK0765308T3 (da) 2000-09-11
HUT77407A (hu) 1998-04-28
CN1070849C (zh) 2001-09-12
USRE39576E1 (en) 2007-04-17
IL128717A0 (en) 2000-01-31
HU9603454D0 (en) 1997-02-28
PT957087E (pt) 2003-04-30
NO965379D0 (no) 1996-12-13
IL114142A0 (en) 1995-10-31
BR9507995A (pt) 1997-08-05
AU692892B2 (en) 1998-06-18
EP0765308A1 (en) 1997-04-02
JPH10506371A (ja) 1998-06-23
DE69529101D1 (de) 2003-01-16
ES2145282T3 (es) 2000-07-01
SI0957087T1 (en) 2003-04-30
EP0957087A2 (en) 1999-11-17
RU2162841C2 (ru) 2001-02-10
NO308655B1 (no) 2000-10-09

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