FI961914A - Lyhytvaikutteiset dihydropyridiinit - Google Patents

Lyhytvaikutteiset dihydropyridiinit Download PDF

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Publication number
FI961914A
FI961914A FI961914A FI961914A FI961914A FI 961914 A FI961914 A FI 961914A FI 961914 A FI961914 A FI 961914A FI 961914 A FI961914 A FI 961914A FI 961914 A FI961914 A FI 961914A
Authority
FI
Finland
Prior art keywords
hydrogen
pct
chloro
methyl
nitro
Prior art date
Application number
FI961914A
Other languages
English (en)
Swedish (sv)
Other versions
FI961914A0 (fi
FI110429B (fi
Inventor
Kjell Hjalmar Andersson
Margareta Nordlander
Rolf Christer Westerlund
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI961914A publication Critical patent/FI961914A/fi
Publication of FI961914A0 publication Critical patent/FI961914A0/fi
Application granted granted Critical
Publication of FI110429B publication Critical patent/FI110429B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
FI961914A 1993-11-05 1996-05-06 Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi FI110429B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
SE9303657 1993-11-05
PCT/SE1994/001031 WO1995012578A1 (en) 1993-11-05 1994-11-03 Short-acting dihydropyridines
SE9401031 1994-11-03

Publications (3)

Publication Number Publication Date
FI961914A true FI961914A (fi) 1996-05-06
FI961914A0 FI961914A0 (fi) 1996-05-06
FI110429B FI110429B (fi) 2003-01-31

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961914A FI110429B (fi) 1993-11-05 1996-05-06 Menetelmä farmaseuttisten dihydropyridiinien valmistamiseksi

Country Status (36)

Country Link
US (1) US5856346A (fi)
EP (1) EP0726894B1 (fi)
JP (1) JP3712209B2 (fi)
KR (1) KR100331663B1 (fi)
CN (1) CN1049428C (fi)
AT (1) ATE194330T1 (fi)
AU (1) AU685532B2 (fi)
BR (1) BR9407946A (fi)
CA (1) CA2174969C (fi)
CZ (1) CZ285691B6 (fi)
DE (1) DE69425152T2 (fi)
DK (1) DK0726894T3 (fi)
EE (1) EE03230B1 (fi)
EG (1) EG20539A (fi)
ES (1) ES2150544T3 (fi)
FI (1) FI110429B (fi)
FR (1) FR12C0053I2 (fi)
GR (1) GR3034469T3 (fi)
HK (1) HK1013292A1 (fi)
HU (1) HU215591B (fi)
IL (1) IL111127A (fi)
IS (1) IS1674B (fi)
LU (1) LU92209I2 (fi)
MY (1) MY111770A (fi)
NO (1) NO305656B1 (fi)
NZ (1) NZ275915A (fi)
PL (1) PL185099B1 (fi)
PT (1) PT726894E (fi)
RU (1) RU2139278C1 (fi)
SA (1) SA94150250B1 (fi)
SE (1) SE9303657D0 (fi)
SK (1) SK281467B6 (fi)
TW (1) TW279859B (fi)
UA (1) UA45959C2 (fi)
WO (1) WO1995012578A1 (fi)
ZA (1) ZA947570B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
CA2467759C (en) * 2001-12-21 2012-04-03 Alcon, Inc. Use of nanoparticles as carriers for biocides in ophthalmic compositions
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
CA3108961A1 (en) * 2008-08-01 2010-02-04 Hospira, Inc. Pharmaceutical compositions comprising clevidipine and methods for producing low impurity concentrations of the same
KR101644286B1 (ko) * 2009-09-30 2016-08-10 마이크로도스 테라퓨특스, 인코포레이티드 레이노 증후군의 치료를 위한 방법들 및 조성물들
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
ES2571043T3 (es) 2010-05-07 2016-05-23 Lesvi Laboratorios Sl Preparación de dihidropiridinas
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
HUE026295T2 (en) 2010-10-12 2016-06-28 The Medicines Co Clevidipine emulsion formulations containing antimicrobial agents
US20150094344A1 (en) * 2011-04-01 2015-04-02 The Medicines Company Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage
EP2747757A1 (en) 2011-08-26 2014-07-02 Wockhardt Limited Methods for treating cardiovascular disorders
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
BR112015009291B1 (pt) 2012-10-26 2021-03-16 Chiesi Farmaceutici S.P.A uso de clevidipina para controle da pressão arterial e redução da dispneia na insuficiência cardíaca
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
RU2759673C2 (ru) 2014-05-19 2021-11-16 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Наночастицы клевидипина и их фармацевтические композиции
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
RS62130B1 (sr) 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health Usa Inc Antihelmintička depsipeptidna jedinjenja
MY194716A (en) 2015-12-28 2022-12-15 Merial Inc Anthelmintic depsipeptide compounds
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
KR940003492B1 (ko) * 1988-10-27 1994-04-23 주식회사 유한양행 1,4-디하이드로피리딘유도체 및 그의 제조방법
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
JPH0641075A (ja) * 1990-09-01 1994-02-15 Kazuo Achinami 新規な１，４−ジヒドロピリジン化合物及びその製造方法

Also Published As

Publication number Publication date
EE03230B1 (et) 1999-10-15
FR12C0053I1 (fi) 2012-02-11
NO961776L (no) 1996-05-02
AU8119694A (en) 1995-05-23
PT726894E (pt) 2000-10-31
FR12C0053I2 (fr) 2013-08-16
RU2139278C1 (ru) 1999-10-10
EP0726894B1 (en) 2000-07-05
CN1049428C (zh) 2000-02-16
PL185099B1 (pl) 2003-02-28
CN1137269A (zh) 1996-12-04
GR3034469T3 (en) 2000-12-29
HU9601187D0 (en) 1996-07-29
IL111127A (en) 2000-11-21
DE69425152T2 (de) 2001-03-22
CZ285691B6 (cs) 1999-10-13
HK1013292A1 (en) 1999-08-20
FI961914A0 (fi) 1996-05-06
UA45959C2 (uk) 2002-05-15
DE69425152D1 (de) 2000-08-10
KR100331663B1 (ko) 2002-09-26
CZ127396A3 (en) 1996-09-11
PL314128A1 (en) 1996-08-19
LU92209I2 (fr) 2013-08-23
ZA947570B (en) 1995-05-29
AU685532B2 (en) 1998-01-22
NO961776D0 (no) 1996-05-02
IS1674B (is) 1997-12-31
IS4218A (is) 1995-05-06
ATE194330T1 (de) 2000-07-15
SA94150250B1 (ar) 2006-03-01
TW279859B (fi) 1996-07-01
EP0726894A1 (en) 1996-08-21
BR9407946A (pt) 1996-11-26
SE9303657D0 (sv) 1993-11-05
JP3712209B2 (ja) 2005-11-02
IL111127A0 (en) 1994-12-29
WO1995012578A1 (en) 1995-05-11
HUT75316A (en) 1997-05-28
ES2150544T3 (es) 2000-12-01
CA2174969A1 (en) 1995-05-11
NO305656B1 (no) 1999-07-05
DK0726894T3 (da) 2000-10-23
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
NZ275915A (en) 1997-04-24
SK55996A3 (en) 1996-12-04
MY111770A (en) 2000-12-30
US5856346A (en) 1999-01-05
EG20539A (en) 1999-07-31
HU215591B (hu) 1999-01-28
FI110429B (fi) 2003-01-31
CA2174969C (en) 2005-05-17

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Owner name: ASTRAZENECA AB

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