FI950893A0 - Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina - Google Patents

Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Info

Publication number
FI950893A0
FI950893A0 FI950893A FI950893A FI950893A0 FI 950893 A0 FI950893 A0 FI 950893A0 FI 950893 A FI950893 A FI 950893A FI 950893 A FI950893 A FI 950893A FI 950893 A0 FI950893 A0 FI 950893A0
Authority
FI
Finland
Prior art keywords
pct
hydroxy
derivatives
nhch2
sch2
Prior art date
Application number
FI950893A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950893A (fi
Inventor
George Robert Brown
Keith Blakeney Mallion
Paul Robert Owen Whittamore
David Robert Brittain
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI950893A publication Critical patent/FI950893A/fi
Publication of FI950893A0 publication Critical patent/FI950893A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI950893A 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina FI950893A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
PCT/GB1993/001802 WO1994005660A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors

Publications (2)

Publication Number Publication Date
FI950893A FI950893A (fi) 1995-02-27
FI950893A0 true FI950893A0 (fi) 1995-02-27

Family

ID=10721113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950893A FI950893A0 (fi) 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Country Status (13)

Country Link
US (1) US5714496A (zh)
EP (1) EP0656897B1 (zh)
JP (1) JPH08502731A (zh)
AT (1) ATE161843T1 (zh)
AU (1) AU4969193A (zh)
CA (2) CA2143430A1 (zh)
DE (1) DE69316224D1 (zh)
FI (1) FI950893A0 (zh)
GB (2) GB9218334D0 (zh)
IL (1) IL106797A0 (zh)
TW (1) TW231293B (zh)
WO (1) WO1994005660A1 (zh)
ZA (1) ZA936201B (zh)

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WO2006019832A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
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US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
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ES2454966T3 (es) 2007-02-01 2014-04-14 Resverlogix Corp. Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
AU2009262252B2 (en) 2008-06-26 2013-05-02 Resverlogix Corp. Methods of preparing quinazolinone derivatives
WO2010079431A2 (en) 2009-01-08 2010-07-15 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ708314A (en) 2009-03-18 2017-08-25 Resverlogix Corp Quinazolinones for use as anticancer agents
ES2706651T3 (es) 2009-04-22 2019-03-29 Resverlogix Corp Nuevos agentes antiinflamatorios
MX2014003043A (es) 2011-09-16 2015-02-05 Pfizer Formas solidas de un inhibidor de disociacion transtiretina.
CN103945848B (zh) 2011-11-01 2016-09-07 雷斯韦洛吉克斯公司 被取代的喹唑啉酮的口服即释制剂
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

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Also Published As

Publication number Publication date
AU4969193A (en) 1994-03-29
JPH08502731A (ja) 1996-03-26
TW231293B (zh) 1994-10-01
GB9218334D0 (en) 1992-10-14
FI950893A (fi) 1995-02-27
IL106797A0 (en) 1993-12-08
ATE161843T1 (de) 1998-01-15
WO1994005660A1 (en) 1994-03-17
EP0656897B1 (en) 1998-01-07
ZA936201B (en) 1994-02-28
CA2143430A1 (en) 1994-03-17
US5714496A (en) 1998-02-03
CA2104981A1 (en) 1994-03-01
DE69316224D1 (de) 1998-02-12
EP0656897A1 (en) 1995-06-14
GB9317153D0 (en) 1993-10-06

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