FI892222A - Peptidalkoholer med antikoagulantverkan. - Google Patents

Peptidalkoholer med antikoagulantverkan. Download PDF

Info

Publication number
FI892222A
FI892222A FI892222A FI892222A FI892222A FI 892222 A FI892222 A FI 892222A FI 892222 A FI892222 A FI 892222A FI 892222 A FI892222 A FI 892222A FI 892222 A FI892222 A FI 892222A
Authority
FI
Finland
Prior art keywords
peptidal
anticoagulant
alcohol
network
formula
Prior art date
Application number
FI892222A
Other languages
English (en)
Other versions
FI892222A0 (fi
Inventor
John Leonard Krstenansky
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI892222A0 publication Critical patent/FI892222A0/fi
Publication of FI892222A publication Critical patent/FI892222A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI892222A 1988-05-10 1989-05-09 Peptidalkoholer med antikoagulantverkan. FI892222A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19240988A 1988-05-10 1988-05-10

Publications (2)

Publication Number Publication Date
FI892222A0 FI892222A0 (fi) 1989-05-09
FI892222A true FI892222A (fi) 1989-11-11

Family

ID=22709524

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892222A FI892222A (fi) 1988-05-10 1989-05-09 Peptidalkoholer med antikoagulantverkan.

Country Status (18)

Country Link
EP (1) EP0341607B1 (fi)
JP (1) JP2916164B2 (fi)
KR (1) KR0131378B1 (fi)
CN (1) CN1041157A (fi)
AT (1) ATE108801T1 (fi)
AU (1) AU626070B2 (fi)
CA (1) CA1341354C (fi)
DE (1) DE68916850T2 (fi)
DK (1) DK226889A (fi)
ES (1) ES2060689T3 (fi)
FI (1) FI892222A (fi)
HU (1) HU202556B (fi)
IL (1) IL90220A0 (fi)
NO (1) NO891894L (fi)
NZ (1) NZ228995A (fi)
PH (1) PH26973A (fi)
PT (1) PT90504B (fi)
ZA (1) ZA893346B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633128B2 (en) * 1987-01-23 1993-01-21 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
US5574012A (en) * 1990-07-24 1996-11-12 Merrell Pharmaceuticals Inc. Analogs of hirudin having anti-platelet activity
ATE142648T1 (de) * 1990-07-24 1996-09-15 Merrell Pharma Inc Antigerinnungspeptide
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
ZA883444B (fi) * 1987-05-21 1988-11-16
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides

Also Published As

Publication number Publication date
JPH01313500A (ja) 1989-12-18
JP2916164B2 (ja) 1999-07-05
IL90220A0 (en) 1989-12-15
KR900018138A (ko) 1990-12-20
HU202556B (en) 1991-03-28
NO891894D0 (no) 1989-05-09
CN1041157A (zh) 1990-04-11
NO891894L (no) 1989-11-13
ES2060689T3 (es) 1994-12-01
ATE108801T1 (de) 1994-08-15
EP0341607A3 (en) 1991-03-27
CA1341354C (en) 2002-04-02
KR0131378B1 (ko) 1998-04-11
ZA893346B (en) 1990-01-31
HUT51295A (en) 1990-04-28
AU626070B2 (en) 1992-07-23
FI892222A0 (fi) 1989-05-09
EP0341607A2 (en) 1989-11-15
PT90504B (pt) 1994-08-31
AU3451789A (en) 1989-11-16
EP0341607B1 (en) 1994-07-20
DK226889D0 (da) 1989-05-09
PT90504A (pt) 1989-11-30
PH26973A (en) 1992-12-28
DE68916850D1 (de) 1994-08-25
NZ228995A (en) 1992-03-26
DK226889A (da) 1989-11-11
DE68916850T2 (de) 1994-10-27

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Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: MERRELL DOW PHARMACEUTICALS INC.